دورية أكاديمية
أعرض في EDS

Synergy of R-(-)carvone and cyclohexenone-based carbasugar precursors with antibiotics to enhance antibiotic potency and inhibit biofilm formation.

التفاصيل البيبلوغرافية
العنوان: Synergy of R-(-)carvone and cyclohexenone-based carbasugar precursors with antibiotics to enhance antibiotic potency and inhibit biofilm formation.
المؤلفون: Riester O; Institute of Precision Medicine, Furtwangen University, Jakob-Kienzle-Strasse 17, 78054, Villingen-Schwenningen, Germany.; Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard-Karls-University Tuebingen, Auf Der Morgenstelle 8, 72076, Tübingen, Germany., Burkhardtsmaier P; Institute of Precision Medicine, Furtwangen University, Jakob-Kienzle-Strasse 17, 78054, Villingen-Schwenningen, Germany., Gurung Y; Institute of Precision Medicine, Furtwangen University, Jakob-Kienzle-Strasse 17, 78054, Villingen-Schwenningen, Germany., Laufer S; Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard-Karls-University Tuebingen, Auf Der Morgenstelle 8, 72076, Tübingen, Germany.; Tuebingen Center for Academic Drug Discovery and Development (TüCAD2), 72076, Tübingen, Germany., Deigner HP; Institute of Precision Medicine, Furtwangen University, Jakob-Kienzle-Strasse 17, 78054, Villingen-Schwenningen, Germany.; Faculty of Science, Eberhard-Karls-University Tuebingen, Auf Der Morgenstelle 8, 72076, Tübingen, Germany.; EXIM Department, Fraunhofer Institute IZI (Leipzig), Schillingallee 68, 18057, Rostock, Germany., Schmidt MS; Institute of Precision Medicine, Furtwangen University, Jakob-Kienzle-Strasse 17, 78054, Villingen-Schwenningen, Germany. smag@hs-furtwangen.de.
المصدر: Scientific reports [Sci Rep] 2022 Oct 26; Vol. 12 (1), pp. 18019. Date of Electronic Publication: 2022 Oct 26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Anti-Bacterial Agents*/pharmacology , Carbasugars*/pharmacology, Microbial Sensitivity Tests ; Escherichia coli ; Biofilms ; Penicillins/pharmacology ; Streptomycin/pharmacology
مستخلص: The widespread use of antibiotics in recent decades has been a major factor in the emergence of antibiotic resistances. Antibiotic-resistant pathogens pose increasing challenges to healthcare systems in both developing and developed countries. To counteract this, the development of new antibiotics or adjuvants to combat existing resistance to antibiotics is crucial. Glycomimetics, for example carbasugars, offer high potential as adjuvants, as they can inhibit metabolic pathways or biofilm formation due to their similarity to natural substrates. Here, we demonstrate the synthesis of carbasugar precursors (CSPs) and their application as biofilm inhibitors for E. coli and MRSA, as well as their synergistic effect in combination with antibiotics to circumvent biofilm-induced antibiotic resistances. This results in a biofilm reduction of up to 70% for the CSP rac-7 and a reduction in bacterial viability of MRSA by approximately 45% when combined with the otherwise ineffective antibiotic mixture of penicillin and streptomycin.
(© 2022. The Author(s).)
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المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Carbasugars)
0 (Penicillins)
Y45QSO73OB (Streptomycin)
تواريخ الأحداث: Date Created: 20221027 Date Completed: 20221028 Latest Revision: 20230123
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9606123
DOI: 10.1038/s41598-022-22807-8
PMID: 36289389
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-022-22807-8