دورية أكاديمية
أعرض في EDS

Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification.

التفاصيل البيبلوغرافية
العنوان: Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification.
المؤلفون: Muth DR; Department of Ophthalmology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland.; University of Zurich (UZH), 8006 Zurich, Switzerland., Toro MD; Department of Ophthalmology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland.; Department of General and Pediatric Ophthalmology, Medical University of Lublin, 20-093 Lublin, Poland.; Eye Clinic, Public Health Department, University of Naples Federico II, 80138 Naples, Italy., Bajka A; Department of Ophthalmology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland., Jonak K; Department of Biomedical Engineering, Lublin University of Technology, 20-618 Lublin, Poland.; Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, 20-093 Lublin, Poland., Rieder R; Department of Ophthalmology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland., Kohler MM; Department of Ophthalmology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland., Gunzinger JM; Department of Ophthalmology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland., Souied EH; Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, University Paris Est Creteil, 94000 Creteil, France., Engelbert M; Vitreous Retina Macula Consultants of New York, New York, NY 10022, USA.; Department of Ophthalmology, NYU Grossman School of Medicine, New York, NY 10016, USA., Freund KB; Vitreous Retina Macula Consultants of New York, New York, NY 10022, USA.; Department of Ophthalmology, NYU Grossman School of Medicine, New York, NY 10016, USA., Zweifel SA; Department of Ophthalmology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland.
المصدر: Biomedicines [Biomedicines] 2022 Sep 22; Vol. 10 (10). Date of Electronic Publication: 2022 Sep 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: To investigate associations and predictive factors between macular neovascularization (MNV) lesion variants and drusen types in patients with treatment-naïve neovascular age-related macular degeneration (AMD). Methods: Multimodal imaging was retrospectively reviewed for druse type (soft drusen, subretinal drusenoid deposits (SDDs) or mixed) and MNV type (MNV 1, MNV 2, MNV 1/2 or MNV 3). The Consensus on Neovascular AMD Nomenclature (CONAN) classification was used for characterizing MNV at baseline. Results: One eye of each eligible patient was included (n = 191). Patients with predominant SDDs had an increased adjusted odds ratio (aOR) for MNV 2 (23.4453, p = 0.0025) and any type of MNV 3 (8.7374, p < 0.0001). Patients with MNV 1/2 had an aOR for predominant SDDs (0.3284, p = 0.0084). Patients with MNV1 showed an aOR for SDDs (0.0357, p < 0.0001). Eyes with SDDs only without other drusen types showed an aOR for MNV 2 (9.2945, p < 0.0001). Conclusions: SDDs represent a common phenotypic characteristic in AMD eyes with treatment-naïve MNV. The aOR for eyes with predominant SDDs to develop MNV 2 and MNV 3 was much higher, possibly due to their location in the subretinal space. The predominant druse type may help to predict which type of MNV will develop during the course of AMD.
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فهرسة مساهمة: Keywords: AMD; CNV; MNV; OCT; SDDs; age-related macular degeneration; macular neovascularization; reticular pseudodrusen; spectral domain optical coherence tomography; subretinal drusenoid deposits
تواريخ الأحداث: Date Created: 20221027 Latest Revision: 20230308
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9598373
DOI: 10.3390/biomedicines10102370
PMID: 36289632
قاعدة البيانات: MEDLINE
الوصف
تدمد:2227-9059
DOI:10.3390/biomedicines10102370