دورية أكاديمية
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Spectral Analysis and Antiulcer Potential of Lactuca sativa through the Amelioration of Proinflammatory Cytokines and Apoptosis Markers.

التفاصيل البيبلوغرافية
العنوان: Spectral Analysis and Antiulcer Potential of Lactuca sativa through the Amelioration of Proinflammatory Cytokines and Apoptosis Markers.
المؤلفون: Syed RU; Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia., Moni SS; Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia., Lila ASA; Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt., Abdallah MH; Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt., Abouzied AS; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.; Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research, Giza 12553, Egypt., Banu H; Department of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail 81442, Saudi Arabia., Alreshidi KSM; College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia., Alrashidi BMW; College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia., Hadi MA; Department of Pharmaceutics, School of Pharmacy, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo 46551, Ethiopia., El-Horany H; Department of Biochemistry, College of Medicine, University of Hail, Hail 81442, Saudi Arabia.; Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta 31511, Egypt., Abdelwahab SI; Medical Research Center, Jazan University, Jazan 45142, Saudi Arabia., Taha MME; Substance Abuse and Toxicology Research Centre, Jazan University, Jazan 45142, Saudi Arabia.
المصدر: Life (Basel, Switzerland) [Life (Basel)] 2022 Oct 19; Vol. 12 (10). Date of Electronic Publication: 2022 Oct 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101580444 Publication Model: Electronic Cited Medium: Print ISSN: 2075-1729 (Print) Linking ISSN: 20751729 NLM ISO Abbreviation: Life (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2011-
مستخلص: The objective of this study was to characterize the bioactive ingredients and antiulcer effects of Lactuca sativa leaves. Several bioactive chemicals were found in the cold methanolic extract of Lactuca sativa leaves after gas chromatography-mass spectrometry (GC-MS) research: 9,12-octadecadienoic acid (Z,Z)-, cyclononasiloxane, octadecamethyl-, n-hexadecanoic acid, Hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl, octadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, 9-octadecenamide, (Z)-, hexadecanoic acid, stigmasterol, benzothiazole, ethyl iso-allocholate, and octacosane. Distinct fingerprint regions in GCMS indicated the existence of bioactive compounds. The leaf powder of Lactuca sativa (LPL) demonstrated substantial antiulcer properties at 400 mg/kg, which was almost equivalent to the standard drug at 20 mg/kg. The cytokine network was efficiently regulated by reducing the production of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α. The levels of caspase-3 and caspase-9 were also considerably lowered at p < 0.05 significant level.
Competing Interests: The authors declare no conflict of interest.
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معلومات مُعتمدة: RG-21 129 University of Hail; RG-21 129 Scientific Research Deanship at the University of Hail, Saudi Arabia,
فهرسة مساهمة: Keywords: anti-ulcer activity; bioactive compounds; spectral analysis
تواريخ الأحداث: Date Created: 20221027 Latest Revision: 20230308
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9604980
DOI: 10.3390/life12101641
PMID: 36295076
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-1729
DOI:10.3390/life12101641