دورية أكاديمية
أعرض في EDS

Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin.

التفاصيل البيبلوغرافية
العنوان: Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin.
المؤلفون: Artyukhov AA; Department of Biomaterials, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia., Nechaeva AM; Department of Biomaterials, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia., Shtilman MI; Department of Biomaterials, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia., Chistyakov EM; Department of Biomaterials, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia., Svistunova AY; Department of Biomaterials, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia., Bagrov DV; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia., Kuskov AN; Department of Biomaterials, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia., Docea AO; Department of Toxicology, Faculty of Pharmacy, University of Medicine & Pharmacy, 2 Petru Rares, 200349 Craiova, Romania., Tsatsakis AM; Center of Toxicology Science & Research, Division of Morphology, Medical School, University of Crete, Voutes Campus, 71003 Heraklion, Greece., Gurevich L; Department of Materials and Production, Aalborg University, Skjernvej 4A, 9220 Aalborg, Denmark., Mezhuev YO; Department of Biomaterials, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia.
المصدر: Materials (Basel, Switzerland) [Materials (Basel)] 2022 Oct 13; Vol. 15 (20). Date of Electronic Publication: 2022 Oct 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101555929 Publication Model: Electronic Cited Medium: Print ISSN: 1996-1944 (Print) Linking ISSN: 19961944 NLM ISO Abbreviation: Materials (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: May 2010- : Basel, Switzerland : MDPI
Original Publication: Basel, Switzerland : Molecular Diversity Preservation International, 2008-2010.
مستخلص: Application of nanocarriers for drug delivery brings numerous advantages, allowing both minimization of side effects common in systemic drug delivery and improvement in targeting, which has made it the focal point of nanoscience for a number of years. While most of the studies are focused on encapsulation of hydrophobic drugs, delivery of hydrophilic compounds is typically performed via covalent attachment, which often requires chemical modification of the drug and limits the release kinetics. In this paper, we report synthesis of biphilic copolymers of various compositions capable of self-assembly in water with the formation of nanoparticles and suitable for ionic binding of the common anticancer drug doxorubicin. The copolymers are synthesized by radical copolymerization of N-vinyl-2-pyrrolidone and acrylic acid using n-octadecyl-mercaptan as a chain transfer agent. With an increase of the carboxyl group's share in the chain, the role of the electrostatic stabilization factor of the nanoparticles increased as well as the ability of doxorubicin as an ion binder. A mathematical description of the kinetics of doxorubicin binding and release is given and thermodynamic functions for the equilibrium ionic binding of doxorubicin are calculated.
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معلومات مُعتمدة: This research was funded by the Ministry of Science and Higher Education of the Russian Fed-eration. Agreement no. 075-15-2020-792, unique contract identifier RF ---- 190220X0031 Ministry of Science and Higher Education of the Russian Federation
فهرسة مساهمة: Keywords: doxorubicin delivery; poly(N-vinyl-2-pyrrolidone-co-acrylic acid) nanoparticles; release kinetics; targeting
تواريخ الأحداث: Date Created: 20221027 Latest Revision: 20221030
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9609473
DOI: 10.3390/ma15207136
PMID: 36295201
قاعدة البيانات: MEDLINE
الوصف
تدمد:1996-1944
DOI:10.3390/ma15207136