دورية أكاديمية
أعرض في EDS

In Vitro Activity of Essential Oils Distilled from Colombian Plants against Candida auris and Other Candida Species with Different Antifungal Susceptibility Profiles.

التفاصيل البيبلوغرافية
العنوان: In Vitro Activity of Essential Oils Distilled from Colombian Plants against Candida auris and Other Candida Species with Different Antifungal Susceptibility Profiles.
المؤلفون: Zapata-Zapata C; Grupo de Investigación Dermatológica, Universidad de Antioquia, Medellín 050010, Colombia., Loaiza-Oliva M; Grupo de Investigación en Patología Oral, Periodoncia y Cirugía Alveólo-Dentaria, Universidad de Antioquia, Medellín 050010, Colombia., Martínez-Pabón MC; Grupo de Investigación en Patología Oral, Periodoncia y Cirugía Alveólo-Dentaria, Universidad de Antioquia, Medellín 050010, Colombia., Stashenko EE; CROM-MASS-CENIVAM-Universidad Industrial de Santander, Bucaramanga 68002, Colombia., Mesa-Arango AC; Grupo de Investigación Dermatológica, Universidad de Antioquia, Medellín 050010, Colombia.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2022 Oct 12; Vol. 27 (20). Date of Electronic Publication: 2022 Oct 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Candida* , Oils, Volatile*/pharmacology , Oils, Volatile*/chemistry, Antifungal Agents/pharmacology ; Antifungal Agents/chemistry ; Thymol ; Limonene ; Colombia ; Terpenes/chemistry ; Microbial Sensitivity Tests
مستخلص: Multi-drug resistant species such as Candida auris are a global health threat. This scenario has highlighted the need to search for antifungal alternatives. Essential oils (EOs), or some of their major compounds, could be a source of new antifungal molecules. The aim of this study was to evaluate the in vitro activity of EOs and some terpenes against C. auris and other Candida spp. The eleven EOs evaluated were obtained by hydro-distillation from different Colombian plants and the terpenes were purchased. EO chemical compositions were obtained by gas chromatography/mass spectrometry (GC/MS). Antifungal activity was evaluated following the CLSI standard M27, 4th Edition. Cytotoxicity was tested on the HaCaT cell line and fungal growth kinetics were tested by time-kill assays. Candida spp. showed different susceptibility to antifungals and the activity of EOs and terpenes was strain-dependent. The Lippia origanoides (thymol + p -cymene) chemotype EO, thymol, carvacrol, and limonene were the most active, mainly against drug-resistant strains. The most active EOs and terpenes were also slightly cytotoxic on the HaCaT cells. The findings of this study suggest that some EOs and commercial terpenes can be a source for the development of new anti- Candida products and aid the identification of new antifungal targets or action mechanisms.
References: Plants (Basel). 2022 Jun 27;11(13):. (PMID: 35807645)
J Fungi (Basel). 2020 Sep 22;6(3):. (PMID: 32971732)
J Mycol Med. 2020 Apr;30(1):100911. (PMID: 32008964)
Clin Infect Dis. 2021 Nov 2;73(9):e2836-e2837. (PMID: 33070175)
Front Cell Infect Microbiol. 2020 Apr 30;10:192. (PMID: 32426298)
Antimicrob Agents Chemother. 2021 Mar 18;65(4):. (PMID: 33468460)
Antioxidants (Basel). 2021 Oct 14;10(10):. (PMID: 34679750)
Folia Microbiol (Praha). 2020 Aug;65(4):775-783. (PMID: 32193708)
Molecules. 2011 Jul 29;16(8):6422-31. (PMID: 25134762)
Med Mycol. 2018 Oct 1;56(7):816-827. (PMID: 29228397)
Fungal Genet Biol. 2019 Nov;132:103254. (PMID: 31326470)
Eukaryot Cell. 2015 Apr;14(4):324-34. (PMID: 25636321)
Sci Rep. 2020 Jan 24;10(1):1162. (PMID: 31980703)
J Med Microbiol. 2009 Aug;58(Pt 8):1074-1079. (PMID: 19528168)
Planta Med. 2010 Jun;76(9):882-8. (PMID: 20104443)
Antimicrob Agents Chemother. 1998 May;42(5):1207-12. (PMID: 9593151)
Antimicrob Agents Chemother. 2017 Apr 24;61(5):. (PMID: 28223375)
Nat Prod Res. 2017 Nov;31(22):2675-2679. (PMID: 28278678)
Chem Rev. 2021 Mar 24;121(6):3390-3411. (PMID: 32441527)
Curr Opin Microbiol. 2018 Oct;45:70-76. (PMID: 29547801)
BMC Complement Med Ther. 2021 Jul 2;21(1):187. (PMID: 34215249)
J Med Microbiol. 2019 Sep;68(9):1353-1358. (PMID: 31271350)
Exp Parasitol. 2012 Oct;132(2):123-8. (PMID: 22771867)
J Clin Microbiol. 2014 Jul;52(7):2609-14. (PMID: 24829248)
Appl Environ Microbiol. 2013 Jun;79(12):3590-600. (PMID: 23542628)
Molecules. 2019 Jun 05;24(11):. (PMID: 31195752)
Pharmaceutics. 2022 Jan 13;14(1):. (PMID: 35057078)
Molecules. 2019 Jan 31;24(3):. (PMID: 30709044)
Can J Microbiol. 2008 Nov;54(11):950-6. (PMID: 18997851)
Molecules. 2018 May 08;23(5):. (PMID: 29738503)
PLoS Pathog. 2012;8(5):e1002718. (PMID: 22615574)
Mycopathologia. 2019 Oct;184(5):615-623. (PMID: 31359292)
Antimicrob Agents Chemother. 2013 Oct;57(10):4769-81. (PMID: 23877676)
Curr Med Chem. 2019;26(29):5501-5541. (PMID: 30182844)
Toxicol In Vitro. 2021 Aug;74:105158. (PMID: 33823240)
Plant Dis. 2021 Jun;105(6):1692-1701. (PMID: 32940579)
Mem Inst Oswaldo Cruz. 2002 Oct;97(7):1027-31. (PMID: 12471432)
J Mycol Med. 2015 Sep;25(3):213-7. (PMID: 26281965)
Molecules. 2019 Dec 13;24(24):. (PMID: 31847159)
mSphere. 2018 Jul 11;3(4):. (PMID: 29997121)
Med Mycol. 2018 Jul 1;56(5):565-578. (PMID: 29420815)
BMC Complement Altern Med. 2018 Jul 27;18(1):225. (PMID: 30053848)
Mol Med Rep. 2018 Jul;18(1):763-770. (PMID: 29845192)
Clin Microbiol Rev. 2017 Nov 15;31(1):. (PMID: 29142078)
Curr Comput Aided Drug Des. 2019;15(3):235-242. (PMID: 30332973)
معلومات مُعتمدة: RC-FP44842-212-2018 Ministerio de Ciencia, Tecnología e Innovación, Ministerio de Educación Nacional, Ministerio de Industria, Comercio y Turismo, and ICETEX, Programme Ecosistema Científico-Colombia Científica from Fondo Francisco José de Caldas
فهرسة مساهمة: Keywords: Candida spp.; Candida auris; Lippia spp.; MIC; antifungal agents; cytotoxicity; essential oils; time–kill assays
المشرفين على المادة: 0 (Antifungal Agents)
0 (Oils, Volatile)
3J50XA376E (Thymol)
9MC3I34447 (Limonene)
0 (Terpenes)
تواريخ الأحداث: Date Created: 20221027 Date Completed: 20221028 Latest Revision: 20221030
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9606955
DOI: 10.3390/molecules27206837
PMID: 36296428
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules27206837