دورية أكاديمية
أعرض في EDS

Uncovering the mechanisms of transcription elongation by eukaryotic RNA polymerases I, II, and III.

التفاصيل البيبلوغرافية
العنوان: Uncovering the mechanisms of transcription elongation by eukaryotic RNA polymerases I, II, and III.
المؤلفون: Jacobs RQ; Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Carter ZI; Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Lucius AL; Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Schneider DA; Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
المصدر: IScience [iScience] 2022 Oct 08; Vol. 25 (11), pp. 105306. Date of Electronic Publication: 2022 Oct 08 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: Eukaryotes express three nuclear RNA polymerases (Pols I, II, and III) that are essential for cell survival. Despite extensive investigation of the three Pols, significant knowledge gaps regarding their biochemical properties remain because each Pol has been evaluated independently under disparate experimental conditions and methodologies. To advance our understanding of the Pols, we employed identical in vitro transcription assays for direct comparison of their elongation rates, elongation complex (EC) stabilities, and fidelities. Pol I is the fastest, most likely to misincorporate, forms the least stable EC, and is most sensitive to alterations in reaction buffers. Pol II is the slowest of the Pols, forms the most stable EC, and negligibly misincorporated an incorrect nucleotide. The enzymatic properties of Pol III were intermediate between Pols I and II in all assays examined. These results reveal unique enzymatic characteristics of the Pols that provide new insights into their evolutionary divergence.
Competing Interests: The authors declare no competing interests.
(© 2022 The Author(s).)
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معلومات مُعتمدة: R35 GM140710 United States GM NIGMS NIH HHS; T32 GM008111 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: Biochemistry; Evolutionary mechanisms; Molecular genetics
تواريخ الأحداث: Date Created: 20221028 Latest Revision: 20231020
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9593817
DOI: 10.1016/j.isci.2022.105306
PMID: 36304104
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2022.105306