دورية أكاديمية
Effect of weekly 17-hydroxyprogesterone caproate on small for gestational age among pregnant women with HIV in Zambia.
| العنوان: | Effect of weekly 17-hydroxyprogesterone caproate on small for gestational age among pregnant women with HIV in Zambia. |
|---|---|
| المؤلفون: | Conner MG; University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Vwalika B; University of Zambia School of Medicine., Freeman BL; University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Sebastião YV; University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Mabula-Bwalya CM; University of North Carolina Global Projects Zambia, Lusaka, Zambia., Cole SR; University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Stringer EM; University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Kasaro MP; University of North Carolina Global Projects Zambia, Lusaka, Zambia., Stringer JSA; University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Price JT; University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. |
| المصدر: | AIDS (London, England) [AIDS] 2022 Nov 15; Vol. 36 (14), pp. 2079-2081. Date of Electronic Publication: 2022 Aug 18. |
| نوع المنشور: | Clinical Trial; Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8710219 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5571 (Electronic) Linking ISSN: 02699370 NLM ISO Abbreviation: AIDS Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : London, England : Lippincott Williams & Wilkins Original Publication: London : Gower Academic Journals, c1987- |
| مواضيع طبية MeSH: | 17 alpha-Hydroxyprogesterone Caproate*/adverse effects , HIV Infections*/drug therapy , Premature Birth*, Female ; Humans ; Infant ; Pregnancy ; 17-alpha-Hydroxyprogesterone ; Gestational Age ; Hydroxyprogesterones ; Pregnant Women ; Zambia |
| مستخلص: | The IPOP trial demonstrated a reduced risk of severe small for gestational age among infants born to women with HIV who received weekly intramuscular 17 alpha-hydroxyprogesterone caproate. This secondary analysis examined the 17P treatment effect in subgroups of maternal BMI, parity, timing of antiretroviral therapy (ART) initiation, and ART regimen. We found that 17P was more effective among nulliparous women, women who started ART before pregnancy, and those taking protease inhibitors. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.) |
| References: | Wedi CO, Kirtley S, Hopewell S, Corrigan R, Kennedy SH, Hemelaar J. Perinatal outcomes associated with maternal HIV infection: a systematic review and meta-analysis . Lancet HIV 2016; 3:e33–48. Li N, Sando MM, Spiegelman D, Hertzmark E, Liu E, Sando D, et al. Antiretroviral therapy in relation to birth outcomes among HIV-infected women: a cohort study . J Infect Dis 2016; 213:1057–1064. Mohammadi H, Papp E, Cahill L, Rennie M, Banko N, Pinnaduwage L, et al. HIV antiretroviral exposure in pregnancy induces detrimental placenta vascular changes that are rescued by progesterone supplementation . Sci Rep 2018; 8:6552. Price JT, Vwalika B, Freeman BL, Cole SR, Saha PT, Mbewe FM, et al. Weekly 17 alpha-hydroxyprogesterone caproate to prevent preterm birth among women living with HIV: a randomised, double-blind, placebo-controlled trial . Lancet HIV 2021; 8:10. Price JT, Vwalika B, Freeman BL, Cole SR, Mulenga HB, Winston J, et al. Intramuscular 17-hydroxyprogesterone caproate to prevent preterm birth among HIV-infected women in Zambia: study protocol of the IPOP randomized trial . BMC Pregnancy Childbirth 2019; 19:81. Villar J, Cheikh Ismail L, Victora CG, Ohuma EO, Bertino E, Altman DG, et al. International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project . Lancet 2014; 384:857–868. |
| معلومات مُعتمدة: | R01 HD087119 United States HD NICHD NIH HHS; D43 TW010558 United States TW FIC NIH HHS; D43 TW009340 United States TW FIC NIH HHS; K01 TW010857 United States TW FIC NIH HHS; T32 HD075731 United States HD NICHD NIH HHS |
| المشرفين على المادة: | 276F2O42F5 (17 alpha-Hydroxyprogesterone Caproate) 68-96-2 (17-alpha-Hydroxyprogesterone) 0 (Hydroxyprogesterones) |
| تواريخ الأحداث: | Date Created: 20221028 Date Completed: 20221101 Latest Revision: 20231116 |
| رمز التحديث: | 20231116 |
| مُعرف محوري في PubMed: | PMC9624437 |
| DOI: | 10.1097/QAD.0000000000003362 |
| PMID: | 36305188 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-5571 |
|---|---|
| DOI: | 10.1097/QAD.0000000000003362 |