دورية أكاديمية
Understanding host responses to equine encephalitis virus infection: implications for therapeutic development.
| العنوان: | Understanding host responses to equine encephalitis virus infection: implications for therapeutic development. |
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| المؤلفون: | Kehn-Hall K; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.; Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Tech, Blacksburg, VA, USA., Bradfute SB; Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. |
| المصدر: | Expert review of anti-infective therapy [Expert Rev Anti Infect Ther] 2022 Dec; Vol. 20 (12), pp. 1551-1566. Date of Electronic Publication: 2022 Nov 04. |
| نوع المنشور: | Review; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101181284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8336 (Electronic) Linking ISSN: 14787210 NLM ISO Abbreviation: Expert Rev Anti Infect Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: London : Future Drugs Ltd. |
| مواضيع طبية MeSH: | Encephalitis Virus, Venezuelan Equine*/physiology , Alphavirus* , Encephalomyelitis, Equine*/drug therapy , Virus Diseases*, Animals ; Humans ; Horses ; Encephalitis Virus, Western Equine/physiology |
| مستخلص: | Introduction: Venezuelan, eastern, and western equine encephalitis viruses (VEEV, EEEV, and WEEV) are mosquito-borne New World alphaviruses that cause encephalitis in equids and humans. These viruses can cause severe disease and death, as well as long-term severe neurological symptoms in survivors. Despite the pathogenesis and weaponization of these viruses, there are no approved therapeutics for treating infection. Areas Covered: In this review, we describe the molecular pathogenesis of these viruses, discuss host-pathogen interactions needed for viral replication, and highlight new avenues for drug development with a focus on host-targeted approaches. Expert Opinion: Current approaches have yielded some promising therapeutics, but additional emphasis should be placed on advanced development of existing small molecules and pursuit of pan-encephalitic alphavirus drugs. More research should be conducted on EEEV and WEEV, given their high lethality rates. |
| فهرسة مساهمة: | Keywords: Alphavirus; encephalitis; equine; host-pathogen interaction; pathogenesis; therapeutics |
| تواريخ الأحداث: | Date Created: 20221028 Date Completed: 20221123 Latest Revision: 20230110 |
| رمز التحديث: | 20230111 |
| DOI: | 10.1080/14787210.2022.2141224 |
| PMID: | 36305549 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1744-8336 |
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| DOI: | 10.1080/14787210.2022.2141224 |