دورية أكاديمية
أعرض في EDS

Cell-Taxi: Mesenchymal Cells Carry and Transport Clusters of Cancer Cells.

التفاصيل البيبلوغرافية
العنوان: Cell-Taxi: Mesenchymal Cells Carry and Transport Clusters of Cancer Cells.
المؤلفون: Zarubova J; Department of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA.; Department of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Prague, 14220, Czech Republic., Hasani-Sadrabadi MM; Department of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA., Norris SCP; Department of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA., Majedi FS; Department of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA., Xiao C; Department of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA., Kasko AM; Department of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA., Li S; Department of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA.
المصدر: Small (Weinheim an der Bergstrasse, Germany) [Small] 2022 Dec; Vol. 18 (50), pp. e2203515. Date of Electronic Publication: 2022 Oct 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101235338 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-6829 (Electronic) Linking ISSN: 16136810 NLM ISO Abbreviation: Small Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH, c2005-
مواضيع طبية MeSH: Mesenchymal Stem Cells* , Neoplasms*/pathology, Humans ; Cell Movement ; Stromal Cells ; Cell Line, Tumor
مستخلص: Cell clusters that collectively migrate from primary tumors appear to be far more potent in forming distant metastases than single cancer cells. A better understanding of the collective cell migration phenomenon and the involvement of various cell types during this process is needed. Here, an in vitro platform based on inverted-pyramidal microwells to follow and quantify the collective migration of hundreds of tumor cell clusters at once is developed. These results indicate that mesenchymal stromal cells (MSCs) or cancer-associated fibroblasts (CAFs) in the heterotypic tumor cell clusters may facilitate metastatic dissemination by transporting low-motile cancer cells in a Rac-dependent manner and that extracellular vesicles secreted by mesenchymal cells only play a minor role in this process. Furthermore, in vivo studies show that cancer cell spheroids containing MSCs or CAFs have faster spreading rates. These findings highlight the active role of co-traveling stromal cells in the collective migration of tumor cell clusters and may help in developing better-targeted therapies.
(© 2022 Wiley-VCH GmbH.)
References: Oncotarget. 2017 May 11;8(43):73693-73704. (PMID: 29088737)
Nat Cell Biol. 2007 Dec;9(12):1392-400. (PMID: 18037882)
Proc Natl Acad Sci U S A. 2016 May 3;113(18):4947-52. (PMID: 27091969)
FASEB J. 2016 Jun;30(6):2161-70. (PMID: 26902610)
PLoS One. 2014 Feb 13;9(2):e88772. (PMID: 24551161)
Science. 2020 Nov 20;370(6519):987-990. (PMID: 33214282)
Cell. 2014 Aug 28;158(5):1110-1122. (PMID: 25171411)
Gene Ther. 2008 May;15(10):730-8. (PMID: 18401438)
Annu Rev Biomed Eng. 2016 Jul 11;18:159-80. (PMID: 27420571)
Curr Biol. 2015 Jan 19;25(2):242-250. (PMID: 25578904)
Nat Cell Biol. 2010 Oct;12(10):943-53. (PMID: 20871601)
Biomaterials. 2016 Jan;76:66-75. (PMID: 26519649)
Ann Biomed Eng. 2017 May;45(5):1365-1374. (PMID: 28091965)
BMC Cancer. 2020 Sep 11;20(1):873. (PMID: 32917154)
Biotechnol J. 2008 Oct;3(9-10):1172-84. (PMID: 18566957)
Sci Adv. 2020 Jan 03;6(1):eaau5670. (PMID: 31921998)
J Extracell Vesicles. 2019 Apr 29;8(1):1609206. (PMID: 31069028)
Cancer Res. 2015 Nov 15;75(22):4681-7. (PMID: 26471358)
Cancer Res. 2004 Dec 1;64(23):8492-5. (PMID: 15574751)
ACS Appl Mater Interfaces. 2021 Feb 10;13(5):5929-5944. (PMID: 33502154)
Curr Opin Cell Biol. 2019 Feb;56:71-79. (PMID: 30308331)
Nat Cell Biol. 2018 Mar;20(3):296-306. (PMID: 29403038)
Trends Cell Biol. 2015 Sep;25(9):556-66. (PMID: 26137890)
Nat Cell Biol. 2017 Mar;19(3):224-237. (PMID: 28218910)
Cancer Res. 2010 Nov 15;70(22):9413-22. (PMID: 21045155)
Nat Rev Mol Cell Biol. 2008 Oct;9(10):796-809. (PMID: 18784728)
Front Immunol. 2018 Nov 15;9:2650. (PMID: 30524429)
Oncotarget. 2016 Oct 18;7(42):68803-68820. (PMID: 27626697)
Cell. 2011 Oct 14;147(2):275-92. (PMID: 22000009)
Nat Rev Mol Cell Biol. 2012 Oct;13(10):631-45. (PMID: 23000794)
J Clin Invest. 2013 Jan;123(1):189-205. (PMID: 23318994)
Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):12926-12931. (PMID: 30504144)
Cancer Med. 2019 Sep;8(12):5574-5576. (PMID: 31397113)
Cancer Res. 2005 Jun 15;65(12):5278-83. (PMID: 15958574)
Nature. 2007 Oct 4;449(7162):557-63. (PMID: 17914389)
Nat Commun. 2013;4:1847. (PMID: 23673632)
Int J Oncol. 2016 Dec;49(6):2206-2216. (PMID: 27779656)
Nat Rev Cancer. 2016 Aug 23;16(9):582-98. (PMID: 27550820)
Int J Cancer. 2010 Nov 15;127(10):2323-33. (PMID: 20473928)
Sci Adv. 2020 Apr 29;6(18):eaaz6579. (PMID: 32494680)
Cancer Discov. 2015 Oct;5(10):1086-97. (PMID: 26209539)
Sci Rep. 2015 Jan 07;5:7656. (PMID: 25563751)
Nature. 1997 Feb 6;385(6616):537-40. (PMID: 9020360)
Science. 2016 Apr 8;352(6282):167-9. (PMID: 27124449)
Elife. 2019 Jan 15;8:. (PMID: 30642430)
J Extracell Vesicles. 2018 Nov 23;7(1):1535750. (PMID: 30637094)
Mol Cancer. 2017 Feb 1;16(1):31. (PMID: 28148268)
Sci Adv. 2020 Jul 24;6(30):eaaz6197. (PMID: 32832657)
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21677-82. (PMID: 21098274)
Biochem Biophys Res Commun. 2003 Sep 12;309(1):232-40. (PMID: 12943687)
Nat Commun. 2019 Jan 11;10(1):144. (PMID: 30635553)
Sci Rep. 2017 Oct 27;7(1):14219. (PMID: 29079818)
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E854-63. (PMID: 26831077)
Cancer Cell. 2011 Feb 15;19(2):257-72. (PMID: 21316604)
Sci Rep. 2018 Jan 10;8(1):253. (PMID: 29321576)
Stem Cell Reports. 2015 Jun 9;4(6):1016-30. (PMID: 26028530)
Cell. 2015 Feb 12;160(4):659-672. (PMID: 25679760)
Cell Adh Migr. 2012 May-Jun;6(3):220-30. (PMID: 22863739)
Int J Cancer. 2005 Jul 20;115(6):885-92. (PMID: 15729726)
Clin Cancer Res. 2017 Aug 15;23(16):4769-4779. (PMID: 28420724)
Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2134-41. (PMID: 27035964)
Intravital. 2012 Jul 01;1(1):32-43. (PMID: 29607252)
Nat Commun. 2019 Sep 13;10(1):4185. (PMID: 31519914)
معلومات مُعتمدة: F31 DE026356 United States DE NIDCR NIH HHS; P30 CA016042 United States CA NCI NIH HHS; R01 CA234343 United States CA NCI NIH HHS; R56 DE029157 United States DE NIDCR NIH HHS
فهرسة مساهمة: Keywords: circulating tumor cell clusters; collective cell migration; extracellular vesicles; micropatterned hydrogels; spheroid migration assay
تواريخ الأحداث: Date Created: 20221029 Date Completed: 20221219 Latest Revision: 20240609
رمز التحديث: 20240609
مُعرف محوري في PubMed: PMC9772300
DOI: 10.1002/smll.202203515
PMID: 36307906
قاعدة البيانات: MEDLINE
الوصف
تدمد:1613-6829
DOI:10.1002/smll.202203515