دورية أكاديمية
أعرض في EDS

Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation.

التفاصيل البيبلوغرافية
العنوان: Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation.
المؤلفون: Zenke S; Institute of Immunodeficiency, Medical Center and Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.; Faculty of Biology, Albert-Ludwigs-University, Freiburg, Germany.; Matterhorn Biosciences GmbH, Basel, Switzerland., Sica MP; Medical Physics Department, Centro Atómico Bariloche, Comisión Nacional de Energía Atómica (CNEA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Carlos de Bariloche, Argentina., Steinberg F; Center for Biological Systems Analysis, Albert-Ludwigs-University Freiburg, Freiburg, Germany., Braun J; Institute of Immunodeficiency, Medical Center and Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.; Faculty of Biology, Albert-Ludwigs-University, Freiburg, Germany., Zink A; Institute of Immunodeficiency, Medical Center and Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany., Gavrilov A; Immune Cell Dynamics Group, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland., Hilger A; Department of Pediatrics and Adolescent Medicine, Medical Center and Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany., Arra A; Department of Experimental Pediatrics and Neonatology and Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, Magdeburg, Germany., Brunner-Weinzierl M; Department of Experimental Pediatrics and Neonatology and Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, Magdeburg, Germany., Elling R; Department of Pediatrics and Adolescent Medicine, Medical Center and Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany., Beyersdorf N; Institute of Virology and Immunobiology, University of Würzburg, Würzburg, Germany., Lämmermann T; Immune Cell Dynamics Group, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Smulski CR; Medical Physics Department, Centro Atómico Bariloche, Comisión Nacional de Energía Atómica (CNEA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Carlos de Bariloche, Argentina., Rohr JC; Institute of Immunodeficiency, Medical Center and Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany. jan.rohr@uniklinik-freiburg.de.; Novartis Institutes for Biomedical Research (NIBR), Novartis Pharma AG, Basel, Switzerland. jan.rohr@uniklinik-freiburg.de.
المصدر: Nature communications [Nat Commun] 2022 Oct 29; Vol. 13 (1), pp. 6459. Date of Electronic Publication: 2022 Oct 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: CD28 Antigens*/genetics , CD28 Antigens*/metabolism , Immunoconjugates*, CTLA-4 Antigen/genetics ; Ligands ; Abatacept ; Antigens, CD
مستخلص: Intercellular communication is crucial for collective regulation of cellular behaviors. While clustering T cells have been shown to mutually control the production of key communication signals, it is unclear whether they also jointly regulate their availability and degradation. Here we use newly developed reporter systems, bioinformatic analyses, protein structure modeling and genetic perturbations to assess this. We find that T cells utilize trogocytosis by competing antagonistic receptors to differentially control the abundance of immunoregulatory ligands. Specifically, ligands trogocytosed via CD28 are shuttled to the T cell surface, enabling them to co-stimulate neighboring T cells. In contrast, CTLA4-mediated trogocytosis targets ligands for degradation. Mechanistically, this fate separation is controlled by different acid-sensitivities of receptor-ligand interactions and by the receptor intracellular domains. The ability of CD28 and CTLA4 to confer different fates to trogocytosed ligands reveals an additional layer of collective regulation of cellular behaviors and promotes the robustness of population dynamics.
(© 2022. The Author(s).)
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المشرفين على المادة: 0 (CD28 Antigens)
0 (CTLA-4 Antigen)
0 (Ligands)
7D0YB67S97 (Abatacept)
0 (Antigens, CD)
0 (Immunoconjugates)
تواريخ الأحداث: Date Created: 20221030 Date Completed: 20221101 Latest Revision: 20221223
رمز التحديث: 20221224
مُعرف محوري في PubMed: PMC9617924
DOI: 10.1038/s41467-022-34156-1
PMID: 36309492
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-022-34156-1