دورية أكاديمية
The plasma phospholipidome of the bottlenose dolphin ( Tursiops truncatus ) is modulated by both sex and developmental stage.
| العنوان: | The plasma phospholipidome of the bottlenose dolphin ( Tursiops truncatus ) is modulated by both sex and developmental stage. |
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| المؤلفون: | Monteiro JP; Mass Spectrometry Centre, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal. jpspmonteiro@yahoo.com.; CESAM-Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Aveiro, Portugal., Ferreira HB; Mass Spectrometry Centre, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal. jpspmonteiro@yahoo.com.; CESAM-Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Aveiro, Portugal., Melo T; Mass Spectrometry Centre, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal. jpspmonteiro@yahoo.com.; CESAM-Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Aveiro, Portugal., Flanagan C; Zoomarine, Guia, Albufeira, Portugal., Urbani N; Zoomarine, Guia, Albufeira, Portugal., Neves J; Zoomarine, Guia, Albufeira, Portugal., Domingues P; Mass Spectrometry Centre, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal. jpspmonteiro@yahoo.com.; CESAM-Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Aveiro, Portugal., Domingues MR; Mass Spectrometry Centre, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal. jpspmonteiro@yahoo.com.; CESAM-Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Aveiro, Portugal. |
| المصدر: | Molecular omics [Mol Omics] 2023 Jan 16; Vol. 19 (1), pp. 35-47. Date of Electronic Publication: 2023 Jan 16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101713384 Publication Model: Electronic Cited Medium: Internet ISSN: 2515-4184 (Electronic) Linking ISSN: 25154184 NLM ISO Abbreviation: Mol Omics Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, UK : Royal Society of Chemistry, [2018]- |
| مواضيع طبية MeSH: | Bottle-Nosed Dolphin*, Humans ; Animals ; Male ; Female ; Fatty Acids ; Lysophosphatidylcholines ; Ceramides |
| مستخلص: | Lipidomics represent a valid complementary tool to the biochemical analysis of plasma in humans. However, in cetaceans, these tools have been unexplored. Here, we evaluated how the plasma lipid composition of Tursiops truncatus is modulated by developmental stage and sex, aiming at a potential use of lipidomics in integrated strategies to monitor cetacean health. We characterized the fatty acid profile and detected a total of 26 fatty acids in T. truncatus plasma. The most abundant fatty acids were palmitic acid (C16:0), stearic acid (C18:0) and oleic acid (C18:1n-9). Interestingly, there are consistent differences between the fatty acid profile of mature female and mature male specimens. Phospholipidome analysis identified 320 different lipid species belonging to phosphatidylcholine (PC, 105 lipid species), lysophosphatidylcholine (42), phosphatidylethanolamine (PE, 67), lysophosphatidylethanolamine (18), phosphatidylglycerol (14), lysophosphatidylglycerol (8), phosphatidylinositol (14), lysophosphatidylinositol (2), phosphatidylserine (3), sphingomyelin (45) and ceramides (2) classes. The statistical analysis of the phospholipidome showed that its composition allows discriminating mature animals between sexes and mature males from immature males. Notably, discrimination between sexes is mainly determined by the contents of PE plasmalogens and lysophospholipids (LPC and LPE), while the differences between mature and immature male animals were mainly determined by the levels of PC lipids. This is the first time that a correlation between developmental stage and sex and the lipid composition of the plasma has been established in cetaceans. Being able to discern between age and sex-related changes is an encouraging step towards using these tools to also detect differences related to disease/dysfunction processes. |
| المشرفين على المادة: | 0 (Fatty Acids) 0 (Lysophosphatidylcholines) 0 (Ceramides) |
| تواريخ الأحداث: | Date Created: 20221031 Date Completed: 20230118 Latest Revision: 20230227 |
| رمز التحديث: | 20230227 |
| DOI: | 10.1039/d2mo00202g |
| PMID: | 36314173 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2515-4184 |
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| DOI: | 10.1039/d2mo00202g |