دورية أكاديمية
أعرض في EDS

Early patellofemoral cartilage and bone pathology in a rat model of noninvasive anterior cruciate ligament rupture.

التفاصيل البيبلوغرافية
العنوان: Early patellofemoral cartilage and bone pathology in a rat model of noninvasive anterior cruciate ligament rupture.
المؤلفون: Fleischer MM; Department of Orthopaedic Surgery, Beaumont Health, Royal Oak, MI, USA., Hartner SE; Department of Orthopaedic Surgery, Beaumont Health, Royal Oak, MI, USA., Newton MD; Department of Orthopaedic Surgery, Beaumont Health, Royal Oak, MI, USA., Baker KC; Department of Orthopaedic Surgery, Beaumont Health, Royal Oak, MI, USA.; Bone & Joint Center, Department of Orthopaedic Surgery, Henry Ford Health System, Detroit, MI, USA., Maerz T; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.
المصدر: Connective tissue research [Connect Tissue Res] 2023 Mar; Vol. 64 (2), pp. 175-185. Date of Electronic Publication: 2022 Nov 01.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 0365263 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-8438 (Electronic) Linking ISSN: 03008207 NLM ISO Abbreviation: Connect Tissue Res Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Informa Healthcare
Original Publication: New York, Gordon and Breach Science Publishers.
مواضيع طبية MeSH: Anterior Cruciate Ligament Injuries*/complications , Anterior Cruciate Ligament Injuries*/pathology , Cartilage, Articular*/diagnostic imaging , Cartilage, Articular*/pathology , Osteoarthritis*/pathology, Animals ; Female ; Rats ; Anterior Cruciate Ligament/pathology ; Rats, Inbred Lew ; X-Ray Microtomography/adverse effects
مستخلص: Objective: Anterior cruciate ligament rupture (ACLR) is a risk factor for the development of post-traumatic osteoarthritis (PTOA). While PTOA in the tibiofemoral joint compartment is well-characterized, very little is known about pathology in the patellofemoral compartment after ACL injury. Here, we evaluated the extent to which ACLR induces early patellofemoral joint damage in a rat model.
Methods: Adult female Lewis rats were randomized to noninvasive ACLR or Sham. Two weeks post-injury, contrast-enhanced micro-computed tomography (µCT) of femoral and patellar cartilage was performed using 20% v/v ioxaglate. Morphometric parameters of femoral trochlear and patellar cartilage, subchondral bone, and trabecular bone were derived from µCT. Sagittal Safranin-O/Fast-Green-stained histologic sections were graded using the OARSI score in a blinded fashion.
Results: Cartilage and bone remodelling consistent with an early PTOA phenotype were observed in both femoral trochleas and patellae. ACLR caused osteophyte formation of the patella and pathology in the superficial zone of articular cartilage, including surface fibrillation, fissures, increased cellularity, and abnormal chondrocyte clustering. There were significant increases in thickness of patellar and trochlear cartilage. Loss of subchondral bone thickness, bone volume fraction, and tissue mineral density, as well as changes to patellar and trochlear trabecular microarchitecture, were indicative of catabolic bone remodelling. Several injury-induced changes, including increased cartilage thickness and trabecular spacing and decreased trabecular number were more severe in the patella compared to the trochlea.
Conclusion: The patellofemoral joint develops mild but evident pathology in the early period following ACL rupture, extending the utility of this model to the study of patellofemoral PTOA.
فهرسة مساهمة: Keywords: ACL rupture; Post-traumatic osteoarthritis; bone; cartilage; patellofemoral
تواريخ الأحداث: Date Created: 20221101 Date Completed: 20231002 Latest Revision: 20231002
رمز التحديث: 20240628
DOI: 10.1080/03008207.2022.2136571
PMID: 36318110
قاعدة البيانات: MEDLINE
الوصف
تدمد:1607-8438
DOI:10.1080/03008207.2022.2136571