دورية أكاديمية
أعرض في EDS

Kidney utilization in the Netherlands - do we optimally use our donor organs?

التفاصيل البيبلوغرافية
العنوان: Kidney utilization in the Netherlands - do we optimally use our donor organs?
المؤلفون: Schutter R; Department of Surgery - Organ Donation and Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Vrijlandt WAL; Department of Surgery - Organ Donation and Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Weima GM; Department of Surgery - Organ Donation and Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Pol RA; Department of Surgery - Organ Donation and Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Sanders JF; Department of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Crop MJ; Department of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Leuvenink HGD; Department of Surgery - Organ Donation and Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Moers C; Department of Surgery - Organ Donation and Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
المصدر: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2023 Feb 28; Vol. 38 (3), pp. 787-796.
نوع المنشور: Review; Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8706402 Publication Model: Print Cited Medium: Internet ISSN: 1460-2385 (Electronic) Linking ISSN: 09310509 NLM ISO Abbreviation: Nephrol Dial Transplant Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Oxford University Press
Original Publication: [Berlin ; New York, NY] : Springer International, [c1986-
مواضيع طبية MeSH: Kidney Transplantation* , Tissue and Organ Procurement* , Acute Kidney Injury*, Humans ; Retrospective Studies ; Netherlands ; Donor Selection ; Graft Survival ; Kidney ; Tissue Donors
مستخلص: Background: To ensure optimal utilization of deceased donor kidneys, it is important to understand the precise reasons why kidneys are discarded. In this study we aimed to obtain a comprehensive overview of kidney utilization and discard during the entire donation process in the Netherlands.
Methods: In this retrospective cohort study we analysed kidney utilization of 3856 kidneys in the Netherlands between 1 January 2015 and 31 December 2020. For every kidney that was not transplanted, we determined the moment of and reason for discard through a unique case-by-case assessment.
Results: Kidney discard according to the traditional definition (procured but not transplanted) was 7.8%. However, when kidneys that seemed medically suitable at the beginning of the donation process were also included, many more potential donor kidneys were lost and the total non-utilization was 24.4%. Subjectively presumed impaired organ quality was responsible for 34.2% of all discarded kidneys. Two-thirds of kidneys discarded due to acute kidney injury (AKI) had only AKI stage 1 or 2.
Conclusion: The classical definition of organ discard underestimates the non-utilization of deceased donor kidneys. Strategies to improve kidney utilization could be a revision of the maximum allowed agonal time in donation after circulatory death, careful consideration in reporting and accepting kidneys from donors with AKI and a prospectively filled registry of detailed organ discard reasons, including the 'silent' non-utilization before procurement.
(© The Author(s) 2022. Published by Oxford University Press on behalf of the ERA.)
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فهرسة مساهمة: Keywords: discard; kidney utilization; organ donation
تواريخ الأحداث: Date Created: 20221101 Date Completed: 20230303 Latest Revision: 20230303
رمز التحديث: 20230304
مُعرف محوري في PubMed: PMC9976738
DOI: 10.1093/ndt/gfac300
PMID: 36318454
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-2385
DOI:10.1093/ndt/gfac300