دورية أكاديمية
A Pair of Chromone Epimers and an Acetophenone Glucoside from the Mangrove Endophytic Fungus Mycosphaerella sp. L3A1.
| العنوان: | A Pair of Chromone Epimers and an Acetophenone Glucoside from the Mangrove Endophytic Fungus Mycosphaerella sp. L3A1. |
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| المؤلفون: | Tan Q; School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, P. R. China., Yang W; School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, P. R. China., Zhu G; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, P. R. China., Chen T; School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, P. R. China., Wu J; Guangdong Key Laboratory of Natural Medicine Research and Development & College of Pharmacy, Guangdong Medical University, Dongguan, 523808, P. R. China., Zhu Y; School of Public Health, Sun Yat-sen University, Guangzhou, 510080, P. R. China., Wang B; School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, P. R. China., Yuan J; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, P. R. China., She Z; School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, P. R. China. |
| المصدر: | Chemistry & biodiversity [Chem Biodivers] 2022 Dec; Vol. 19 (12), pp. e202200998. Date of Electronic Publication: 2022 Nov 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004- |
| مواضيع طبية MeSH: | Mycosphaerella* , Chromones*/pharmacology, Fungi ; Crystallography, X-Ray ; Molecular Structure |
| مستخلص: | Three new compounds, including a pair of chromone derivatives (1-2), and an acetophenone glucoside (3), together with three known compounds (4-6), were isolated from the mangrove endophytic fungus Mycosphaerella sp. L3A1. Their structures were elucidated by HR-ESI-MS analysis and extensive spectroscopic data. The absolute configurations of new compounds were determined using single-crystal X-ray diffraction analysis, electronic circular dichroism (ECD) calculations and chemical hydrolysis. In bioassays, compound 4 showed moderate cytotoxic activity against MDA-MB-435, HCT116, and SNB19 with IC (© 2022 Wiley-VHCA AG, Zurich, Switzerland.) |
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| معلومات مُعتمدة: | U20A2001 National Natural Science Foundation of China; 21877133 National Natural Science Foundation of China; GDNRC [2022]35 Guangdong Provincial Department Foundation of Natural Resources; 2020B1111030005 Key-Area Research and Development Program of Guangdong Province |
| فهرسة مساهمة: | Keywords: Mycosphaerella; cytotoxic activity; mangrove endophytic fungus; secondary metabolites |
| المشرفين على المادة: | 0 (Chromones) |
| تواريخ الأحداث: | Date Created: 20221101 Date Completed: 20221227 Latest Revision: 20221230 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/cbdv.202200998 |
| PMID: | 36318651 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1612-1880 |
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| DOI: | 10.1002/cbdv.202200998 |