دورية أكاديمية
Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood.
| العنوان: | Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood. |
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| المؤلفون: | Cavalleri Sousa T; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Presidente Prudente, Brazil., de Oliveira CB; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Presidente Prudente, Brazil., Silva Ricardo ML; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Presidente Prudente, Brazil., Musa de Aquino A; Department of Functional and Structural Biology, IBB/UNESP, Botucatu, Brazil., Scarano WR; Department of Functional and Structural Biology, IBB/UNESP, Botucatu, Brazil., Cruz Veras AS; Experimental Laboratory of Exercise Biology (LEBioEx), São Paulo State University (UNESP), Presidente Prudente, Brazil., Almeida Tavares ME; Experimental Laboratory of Exercise Biology (LEBioEx), São Paulo State University (UNESP), Presidente Prudente, Brazil., Teixeira GR; Experimental Laboratory of Exercise Biology (LEBioEx), São Paulo State University (UNESP), Presidente Prudente, Brazil., Castillho ACD; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Presidente Prudente, Brazil., Pacagnelli FL; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Presidente Prudente, Brazil., Zalotti Brandt J; Department of Nutrition, Unimed Hospital, Botucatu, Brazil., de Oliveira Mendes L; Graduate Program in Animal Science, Western São Paulo University (UNOESTE), Presidente Prudente, Brazil.; Master Program in Health Science, Western São Paulo University (UNOESTE), Presidente Prudente, Brazil. |
| المصدر: | International journal of environmental health research [Int J Environ Health Res] 2024 Jan; Vol. 34 (1), pp. 201-212. Date of Electronic Publication: 2022 Nov 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9106628 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1369-1619 (Electronic) Linking ISSN: 09603123 NLM ISO Abbreviation: Int J Environ Health Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: London : Chapman & Hall, c1991- |
| مواضيع طبية MeSH: | Prostate*/pathology , Estrogens* , Phenols*, Male ; Pregnancy ; Female ; Rats ; Animals ; Genistein/pharmacology ; Benzhydryl Compounds/toxicity ; Phytochemicals/pharmacology ; Collagen/pharmacology |
| مستخلص: | Bisphenol A (BPA) is an environmentally dispersed chemical associated with tumor development. Phytochemicals such as indole-3-carbinol (I3C) and genistein (GEN) have chemoprotective effects on tumor cells. Thus, this study aimed to evaluate the prostatic morphological aspects of rats exposed to BPA, GEN, and I3C during the perinatal period and submitted to hormonal stimulus in adulthood. Blood was collected to obtain hormone concentrations. Slides stained with hematoxylin & eosin, and picrosirius were subjected to fractal, stereological, morphometric, and collagen quantification analysis. I3C decreased the plasma dihydrotestosterone levels, and both phytochemicals increased the plasma estrogen levels. Unlike phytochemicals, BPA did not alter any of the parameters evaluated. GEN reduced the epithelial height, while I3C increased the fractal dimension and stromal collagen. Although BPA did not alter the prostate morphology, the phytochemicals provided beneficial effects for the prostate histological organization in adult animals subjected to hormonal stimulus. |
| فهرسة مساهمة: | Keywords: Endocrine disruptors; genistein; indole-3-carbinol |
| المشرفين على المادة: | MLT3645I99 (bisphenol A) 0 (Estrogens) DH2M523P0H (Genistein) 0 (Benzhydryl Compounds) 0 (Phytochemicals) 9007-34-5 (Collagen) 0 (Phenols) |
| تواريخ الأحداث: | Date Created: 20221101 Date Completed: 20240123 Latest Revision: 20240123 |
| رمز التحديث: | 20240123 |
| DOI: | 10.1080/09603123.2022.2140127 |
| PMID: | 36319067 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1369-1619 |
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| DOI: | 10.1080/09603123.2022.2140127 |