دورية أكاديمية
Clinical significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute exacerbations of COPD: present and future.
| العنوان: | Clinical significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute exacerbations of COPD: present and future. |
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| المؤلفون: | Zinellu A; Department of Biomedical Sciences, University of Sassari, Sassari, Italy., Zinellu E; Department of Respiratory Diseases, University Hospital Sassari (AOU), Sassari, Italy., Mangoni AA; Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, Australia.; Department of Clinical Pharmacology, Flinders Medical Centre, Southern Adelaide Local Health Network, Adelaide, Australia., Pau MC; Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy., Carru C; Department of Biomedical Sciences, University of Sassari, Sassari, Italy., Pirina P; Department of Respiratory Diseases, University Hospital Sassari (AOU), Sassari, Italy.; Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy., Fois AG; Department of Respiratory Diseases, University Hospital Sassari (AOU), Sassari, Italy agfois@uniss.it.; Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy. |
| المصدر: | European respiratory review : an official journal of the European Respiratory Society [Eur Respir Rev] 2022 Nov 02; Vol. 31 (166). Date of Electronic Publication: 2022 Nov 02 (Print Publication: 2022). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: European Respiratory Society Country of Publication: England NLM ID: 9111391 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1600-0617 (Electronic) Linking ISSN: 09059180 NLM ISO Abbreviation: Eur Respir Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sheffield, United Kingdom : European Respiratory Society Original Publication: Copenhagen K, Denmark : Published by the Society and distributed by Munksgaard International Publishers, 1991- |
| مواضيع طبية MeSH: | Neutrophils* , Pulmonary Disease, Chronic Obstructive*/diagnosis , Pulmonary Disease, Chronic Obstructive*/therapy, Humans ; Disease Progression ; Retrospective Studies ; Lymphocytes ; Biomarkers |
| مستخلص: | Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a leading cause of hospitalisation and death in COPD patients. In addition to the identification of better strategies to prevent AECOPD, there is an intense focus on discovering novel markers of disease severity that enhance risk stratification on hospital admission for the targeted institution of aggressive versus supportive treatments. In the quest for such biomarkers, an increasing body of evidence suggests that specific indexes derived from routine complete blood counts, i.e. the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), can significantly predict adverse outcomes in AECOPD. This narrative review discusses the current evidence regarding the association between the NLR and the PLR on admission and several clinical end-points (need for invasive ventilation, noninvasive mechanical ventilation failure, admission to an intensive care unit, pulmonary hypertension, length of hospitalisation, and mortality) in AECOPD. Future research directions and potential clinical applications of these haematological indexes in this patient group are also discussed. Competing Interests: Conflict of interest: The authors declare no conflict of interest. (Copyright ©The authors 2022.) |
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| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20221102 Date Completed: 20221104 Latest Revision: 20221209 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9724880 |
| DOI: | 10.1183/16000617.0095-2022 |
| PMID: | 36323421 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1600-0617 |
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| DOI: | 10.1183/16000617.0095-2022 |