دورية أكاديمية
MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6° head-down tilt bed rest with and without daily centrifugation.
| العنوان: | MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6° head-down tilt bed rest with and without daily centrifugation. |
|---|---|
| المؤلفون: | Sater SH; Alcyone Therapeutics Inc., Lowell, Massachusetts., Conley Natividad G; Alcyone Therapeutics Inc., Lowell, Massachusetts., Seiner AJ; Department of Chemical and Biological Engineering, University of Idaho, Moscow, Idaho., Fu AQ; Department of Mathematics and Statistical Science, Institute of Bioinformatics and Evolutionary Studies, Institute for Modeling Collaboration & Innovation, University of Idaho, Moscow, Idaho., Shrestha D; Department of Chemical and Biological Engineering, University of Idaho, Moscow, Idaho., Bershad EM; Department of Neurology, Baylor College of Medicine, Houston, Texas., Marshall-Goebel K; KBR, Houston, Texas., Laurie SS; KBR, Houston, Texas., Macias BR; Cardiovascular and Vision Laboratory, Johnson Space Center, National Aeronautics and Space Administration, Houston, Texas., Martin BA; Alcyone Therapeutics Inc., Lowell, Massachusetts.; Department of Chemical and Biological Engineering, University of Idaho, Moscow, Idaho. |
| المصدر: | Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2022 Dec 01; Vol. 133 (6), pp. 1349-1355. Date of Electronic Publication: 2022 Nov 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 8502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1601 (Electronic) Linking ISSN: 01617567 NLM ISO Abbreviation: J Appl Physiol (1985) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, MD : American Physiological Society, c1985- |
| مواضيع طبية MeSH: | Gravity, Altered* , Space Flight*, Humans ; Head-Down Tilt ; Bed Rest ; Astronauts ; Magnetic Resonance Imaging |
| مستخلص: | Spaceflight associated neuro-ocular syndrome (SANS) is associated with acquired optic disc edema, hyperopia, and posterior globe flattening in some astronauts during long-duration spaceflight possibly due to the headward fluid redistribution in microgravity. The goal of this study was to assess whether strict head-down tilt (HDT) bed rest as a spaceflight analog would produce globe flattening and whether centrifugation could prevent these changes. Twenty-four healthy subjects separated into three groups underwent 60 days of strict 6° HDT bed rest: one control group with no countermeasure ( n = 8) and two countermeasure groups exposed to 30 min daily of short-arm centrifugation as a means of artificial gravity (AG), either intermittent (iAG, n = 8) or continuous (cAG, n = 8). Magnetic resonance images (MRI) were collected at baseline, HDT-day 14 , HDT-day 52 , and 3 days after bed rest. An automated method was applied to quantify posterior globe volume displacement compared with baseline scans. On average, subjects showed an increasing degree of globe volume displacement with bed rest duration (means ± SE: 1.41 ± 1.01 mm 3 on HDT14 and 4.04 ± 1.19 mm 3 on HDT52) that persisted post-bed rest (5.51 ± 1.26 mm 3 ). Application of 30 min daily AG did not have a significant impact on globe volume displacement ( P = 0.42 for cAG and P = 0.93 for iAG compared with control). These results indicate that strict 6° HDT bed rest produced displacement of the posterior globe with a trend of increasing displacement with longer duration that was not prevented by daily 30 min exposure to AG. NEW & NOTEWORTHY Head-down tilt (HDT) bed rest is commonly used as a spaceflight analog for investigating spaceflight associated neuro-ocular syndrome (SANS). Posterior ocular globe flattening has been identified in astronauts with SANS but until now has not been investigated during HDT bed rest. In this study, posterior ocular globe volume displacement was quantified before, during, and after HDT bed rest and countermeasures were tested for their potential to reduce the degree of globe flattening. |
| التعليقات: | Comment in: J Appl Physiol (1985). 2023 Jan 1;134(1):150-151. (PMID: 36592406) |
| References: | Physiol Rep. 2021 Aug;9(15):e14977. (PMID: 34355874) Ophthalmology. 2019 Mar;126(3):467-468. (PMID: 30308219) NPJ Microgravity. 2020 Feb 7;6:7. (PMID: 32047839) PLoS One. 2020 Sep 18;15(9):e0239228. (PMID: 32946482) Ann Neurol. 2016 Aug;80(2):269-76. (PMID: 27352140) J Glaucoma. 2003 Jun;12(3):204-8. (PMID: 12782836) J Neuroophthalmol. 2013 Sep;33(3):249-55. (PMID: 23851997) Eur J Appl Physiol. 2015 Jun;115(6):1233-44. (PMID: 25667067) Curr Neurol Neurosci Rep. 2018 Apr 12;18(5):25. (PMID: 29651628) Ophthalmology. 2011 Oct;118(10):2058-69. (PMID: 21849212) J Appl Physiol (1985). 2021 Aug 1;131(2):613-620. (PMID: 34166098) Eye (Lond). 2021 Jul;35(7):1869-1878. (PMID: 33514895) Eye (Lond). 2018 Jul;32(7):1164-1167. (PMID: 29527011) JAMA Ophthalmol. 2020 Feb 1;138(2):165-172. (PMID: 31876939) Aerosp Med Hum Perform. 2017 Jan 1;88(1):10-16. (PMID: 28061916) J Appl Physiol (1985). 2015 Jan 1;118(1):29-35. (PMID: 25342708) Neuroophthalmology. 2020 Sep 3;45(1):29-35. (PMID: 33762785) J Physiol. 2017 Mar 15;595(6):2115-2127. (PMID: 28092926) JAMA Ophthalmol. 2020 May 1;138(5):553-559. (PMID: 32239198) |
| معلومات مُعتمدة: | #80NSSC20K0920 NASA | Johnson Space Center (JSC); #NNX10AM75H NASA Idaho Space Grant Consortium; #1R01NS11128301 HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) |
| فهرسة مساهمة: | Keywords: artificial gravity; head-down tilt bed rest; magnetic resonance imaging; ocular globe flattening; spaceflight associated neuro-ocular syndrome |
| تواريخ الأحداث: | Date Created: 20221103 Date Completed: 20221216 Latest Revision: 20230214 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9744655 |
| DOI: | 10.1152/japplphysiol.00082.2022 |
| PMID: | 36326472 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1601 |
|---|---|
| DOI: | 10.1152/japplphysiol.00082.2022 |