دورية أكاديمية
Imaging Findings in Children Presenting with CNS Nelarabine Toxicity.
| العنوان: | Imaging Findings in Children Presenting with CNS Nelarabine Toxicity. |
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| المؤلفون: | Serrallach BL; From the Edward B. Singleton Department of Radiology (B.L.S., S.K.K., B.H.T., T.A.G.M.H., N.K.D.) bettinaserrallach@icloud.com., Schafer ES; Department of Pediatrics (E.S.S.), Section of Hematology-Oncology, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas., Kralik SK; From the Edward B. Singleton Department of Radiology (B.L.S., S.K.K., B.H.T., T.A.G.M.H., N.K.D.)., Tran BH; From the Edward B. Singleton Department of Radiology (B.L.S., S.K.K., B.H.T., T.A.G.M.H., N.K.D.)., Huisman TAGM; From the Edward B. Singleton Department of Radiology (B.L.S., S.K.K., B.H.T., T.A.G.M.H., N.K.D.)., Wright JN; Departments of Radiology (J.N.W.)., Morgan LA; Neurology (L.A.M.), Division of Child Neurology, Seattle Children's Hospital, Seattle, Washington., Desai NK; From the Edward B. Singleton Department of Radiology (B.L.S., S.K.K., B.H.T., T.A.G.M.H., N.K.D.). |
| المصدر: | AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2022 Dec; Vol. 43 (12), pp. 1802-1809. Date of Electronic Publication: 2022 Nov 03. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Neuroradiology Country of Publication: United States NLM ID: 8003708 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-959X (Electronic) Linking ISSN: 01956108 NLM ISO Abbreviation: AJNR Am J Neuroradiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oak Brook, IL : American Society of Neuroradiology Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Posterior Leukoencephalopathy Syndrome* , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy , Spinal Cord Diseases*, Humans ; Child ; Arabinonucleosides/adverse effects |
| مستخلص: | Nelarabine is a nucleoside analog critical for the treatment of patients with T-cell acute lymphoblastic leukemia/lymphoma. However, clinical peripheral and central neurologic adverse events associated with nelarabine administration have been reported. Neuroimaging of brain neurotoxicity has only been described in very few reports in pediatric patients so far. Six children with diagnosed T-cell acute lymphoblastic leukemia who clinically experienced possible, probable, or definite nelarabine-induced toxicity and underwent spine and/or brain MR imaging were reviewed. Neuroimaging findings showed a mixture of patterns including features of acute toxic leukoencephalopathy (seen in 6 cases), posterior reversible encephalopathy syndrome (2 cases), involvement of deep gray structures (1 case) and brainstem (2 cases), cranial and spinal neuropathy (2 cases each), and myelopathy (2 cases). Even though neuroimaging findings are nonspecific, the goal of this article was to alert the pediatric neuroradiologists, radiologists, and clinicians about the possibility of nelarabine-induced neurotoxicity and its broad neuroimaging spectrum. (© 2022 by American Journal of Neuroradiology.) |
| المشرفين على المادة: | 60158CV180 (nelarabine) 0 (Arabinonucleosides) |
| تواريخ الأحداث: | Date Created: 20221103 Date Completed: 20221229 Latest Revision: 20230131 |
| رمز التحديث: | 20230131 |
| DOI: | 10.3174/ajnr.A7692 |
| PMID: | 36328408 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1936-959X |
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| DOI: | 10.3174/ajnr.A7692 |