دورية أكاديمية
أعرض في EDS

Multiple tissue-specific epigenetic alterations regulate persistent gene expression changes following developmental DES exposure in mouse reproductive tissues.

التفاصيل البيبلوغرافية
العنوان: Multiple tissue-specific epigenetic alterations regulate persistent gene expression changes following developmental DES exposure in mouse reproductive tissues.
المؤلفون: Jefferson TB; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA., Wang T; Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA., Jefferson WN; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA., Li Y; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA., Hamilton KJ; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA., Wade PA; Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA., Williams CJ; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA., Korach KS; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, 27709, USA.
المصدر: Epigenetics [Epigenetics] 2023 Dec; Vol. 18 (1), pp. 2139986. Date of Electronic Publication: 2022 Nov 03.
نوع المنشور: Journal Article; Research Support, N.I.H., Intramural
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265293 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-2308 (Electronic) Linking ISSN: 15592294 NLM ISO Abbreviation: Epigenetics Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Georgetown, Tex. : Landes Bioscience, c2006-
مواضيع طبية MeSH: Diethylstilbestrol*/pharmacology , Estrogen Receptor alpha*/genetics, Animals ; Mice ; Male ; Female ; DNA Methylation ; Genome-Wide Association Study ; Epigenesis, Genetic ; Gene Expression
مستخلص: Clinically, developmental exposure to the endocrine disrupting chemical, diethylstilboestrol (DES), results in long-term male and female infertility. Experimentally, developmental exposure to DES results in abnormal reproductive tract phenotypes in male and female mice. Previously, we reported that neonatal DES exposure causes ERα-mediated aberrations in the transcriptome and in DNA methylation in seminal vesicles (SVs) of adult mice. However, only a subset of DES-altered genes could be explained by changes in DNA methylation. We hypothesized that alterations in histone modification may also contribute to the altered transcriptome during SV development. To test this idea, we performed a series of genome-wide analyses of mouse SVs at pubertal and adult developmental stages in control and DES-exposed wild-type and ERα knockout mice. Neonatal DES exposure altered ERα-mediated mRNA and lncRNA expression in adult SV, including genes encoding chromatin-modifying proteins that can impact histone H3K27ac modification. H3K27ac patterns, particularly at enhancers, and DNA methylation were reprogrammed over time during normal SV development and after DES exposure. Some of these reprogramming changes were ERα-dependent, but others were ERα-independent. A substantial number of DES-altered genes had differential H3K27ac peaks at nearby enhancers. Comparison of gene expression changes, H3K27ac marks and DNA methylation marks between adult SV and adult uterine tissue from ovariectomized mice neonatally exposed to DES revealed that most of the epigenetic changes and altered genes were distinct in the two tissues. These findings indicate that the effects of developmental DES exposure cause reprogramming of reproductive tract tissue differentiation through multiple epigenetic mechanisms.
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معلومات مُعتمدة: ZIA ES070065 United States ImNIH Intramural NIH HHS; ZIA ES102405 United States ImNIH Intramural NIH HHS
فهرسة مساهمة: Keywords: Estrogen receptor; histone modification; mouse seminal vesicles; neonatal DES exposure; transcriptome
المشرفين على المادة: 731DCA35BT (Diethylstilbestrol)
0 (Estrogen Receptor alpha)
تواريخ الأحداث: Date Created: 20221103 Date Completed: 20230228 Latest Revision: 20240428
رمز التحديث: 20240428
مُعرف محوري في PubMed: PMC9980695
DOI: 10.1080/15592294.2022.2139986
PMID: 36328762
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-2308
DOI:10.1080/15592294.2022.2139986