دورية أكاديمية
Survival rate and predictors of 36-month mortality in patients with heart failure in Sub Saharan Africa: insights from the Douala Heart Failure Registry (Do-HF).
| العنوان: | Survival rate and predictors of 36-month mortality in patients with heart failure in Sub Saharan Africa: insights from the Douala Heart Failure Registry (Do-HF). |
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| المؤلفون: | Dzudie A; Department of Internal Medicine and Subspecialties, Douala General Hospital, Douala, Cameroon.; Lown Scholar Programs, Cardiovascular Health, Harvard T.H. Chan School of Public Health, USA.; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon., Barche B; Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon., Nkoke C; Faculty of Health Sciences, University of Buea, Buea, Cameroon., Ngatchuesi VG; Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon., Ndom MS; Laquintinie Hospital, Douala, Cameroon., Mouliom S; Department of Internal Medicine and Subspecialties, Douala General Hospital, Douala, Cameroon.; Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon., Ndjebet J; Douala Cardiovascular Center, Douala, Cameroon., Nouko A; Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon., Fogue R; Clinical Research Education Networking & Consultancy (CRENC), Douala, Cameroon., Abang S; Mboppi Baptist Hospital, Douala, Cameroon., Abah J; Douala Military Hospital, Douala, Cameroon., Djomou A; Clinique Coeur et vie, Douala, Cameroon., Nzali A; Centre de Cardiologie Interventionelle de Douala, Douala, Cameroon., Sidikatou D; Faculty of Health Sciences, University of Buea, Buea, Cameroon., Menanga A; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon., Kingue S; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon., Kamdem F; Department of Internal Medicine and Subspecialties, Douala General Hospital, Douala, Cameroon.; Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon., Mbatchou BH; Department of Internal Medicine and Subspecialties, Douala General Hospital, Douala, Cameroon.; Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon., Luma HN; Department of Internal Medicine and Subspecialties, Douala General Hospital, Douala, Cameroon.; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon. |
| المصدر: | Cardiovascular diagnosis and therapy [Cardiovasc Diagn Ther] 2022 Oct; Vol. 12 (5), pp. 577-588. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: AME Publishing Company Country of Publication: China NLM ID: 101601613 Publication Model: Print Cited Medium: Print ISSN: 2223-3652 (Print) Linking ISSN: 22233652 NLM ISO Abbreviation: Cardiovasc Diagn Ther Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: SHEUNG WAN, Hong Kong : AME Publishing Company Original Publication: Hangzhou, China : CDT Office, [2011]- |
| مستخلص: | Background: Heart failure (HF) is a growing public health concern with a high mortality rate in sub-Saharan Africa. However, few studies have reported the long-term predictors of mortality in this region. This study sought to determine the 3-year mortality rate and the predictors of mortality amongst HF patients in Douala, Cameroon. Methods: We conducted a prospective analysis on patients recruited in the Douala Heart Failure (Do-HF) registry, an ongoing prospective data collection on patients with HF at four cardiology units in Douala, Cameroon. Patients included were followed for 36 months from the index date of inclusion, with all-cause mortality as the primary outcome. Cox proportional hazard regression models were used to determine predictors of mortality. Results: Out of the 347 participants included, 318 (91.6%) completed follow-up. The mean age was 64±14 years, 172 (49.6%) were men. Hypertensive cardiomyopathy and dilated cardiomyopathy were the most frequent causes of heart failure. The median follow-up was 33 months, and 150 (47.2%) patients died. Independent predictors of mortality included New York Heart Association functional class III & IV (aHR 2.23; 95% CI: 1.49-3.33; P<0.001), presence of pulmonary rales (aHR 1.87; 95% CI: 1.30-2.68; P=0.005), chronic kidney disease (aHR 2.92; 95% CI: 1.79-4.78; P<0.001), enrolment as inpatient (aHR1.96; 95% CI: 1.17-2.54; P=0.005), no formal education (aHR 2.06; 95% CI: 1.28-3.33; P=0.003), and a monthly income of at most three minimum wage (aHR 2.06; 95% CI: 1.28-3.33; P=0.003). Conclusions: This study shows that almost half of HF patients die after 36 months of follow-up. Also, late presentation and poverty-related conditions were associated with poor outcomes. These findings suggest prioritizing preventive strategies that target early diagnosis and socioeconomic status to improve the prognosis of HF. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://cdt.amegroups.com/article/view/10.21037/cdt-22-166/coif). The authors have no conflicts of interest to declare. (2022 Cardiovascular Diagnosis and Therapy. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: Heart failure (HF); Sub Saharan Africa; mortality; outcome; predictors |
| تواريخ الأحداث: | Date Created: 20221104 Latest Revision: 20221105 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9622412 |
| DOI: | 10.21037/cdt-22-166 |
| PMID: | 36329966 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2223-3652 |
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| DOI: | 10.21037/cdt-22-166 |