دورية أكاديمية
The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science.
| العنوان: | The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science. |
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| المؤلفون: | Lilly JV; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Rokita JL; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Mason JL; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Patton T; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Stefankiewiz S; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Higgins D; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Trooskin G; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Larouci CA; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Arya K; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Appert E; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Heath AP; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Zhu Y; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Brown MA; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Zhang B; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Farrow BK; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Robins S; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Morgan AM; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Nguyen TQ; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Frenkel E; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Lehmann K; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Drake E; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Sullivan C; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Plisiewicz A; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Coleman N; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Patterson L; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Koptyra M; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Helili Z; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Van Kuren N; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Young N; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Kim MC; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Friedman C; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Lubneuski A; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Blackden C; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Williams M; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Baubet V; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Tauhid L; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Galanaugh J; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Boucher K; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Ijaz H; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Cole KA; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Choudhari N; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Santi M; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Moulder RW; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Waller J; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Rife W; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Diskin SJ; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Mateos M; Sydney Children's Hospital, Sydney, Australia., Parsons DW; Texas Children's Hospital, Houston, TX, USA., Pollack IF; UPMC The Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Goldman S; Phoenix Children's Hospital, Phoenix AZ, USA; University of Arizona College of Medicine, Phoenix AZ, USA., Leary S; Seattle Children's Hospital, Seattle, WA, USA., Caporalini C; Meyer Children's Hospital, Floerence, Italy., Buccoliero AM; Meyer Children's Hospital, Floerence, Italy., Scagnet M; Meyer Children's Hospital, Floerence, Italy., Haussler D; University of California Santa Cruz, Santa Cruz, CA, USA., Hanson D; Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, NJ, USA., Firestein R; Hudson Institute of Medical Research, Victoria, Australia., Cain J; Hudson Institute of Medical Research, Victoria, Australia., Phillips JJ; University of California San Francisco & Benioff Children's Hospitals, San Francisco, CA, USA., Gupta N; University of California San Francisco & Benioff Children's Hospitals, San Francisco, CA, USA., Mueller S; University of California San Francisco & Benioff Children's Hospitals, San Francisco, CA, USA., Grant G; Duke University Medical Center, Durham, NC USA., Monje-Deisseroth M; Lucille Packard Children's Hospital Stanford, Stanford, CA, USA., Partap S; Lucille Packard Children's Hospital Stanford, Stanford, CA, USA., Greenfield JP; Weill Cornell Medicine Pediatric Brain and Spine Center, New York, NY, USA., Hashizume R; Ann and Robert Lurie Children's Hospital, Chicago, IL, USA., Smith A; Orlando Health Arnold Palmer Hospital for Children, Orlando, FL, USA., Zhu S; China National Genebank (Beijing Genomics Institute), China., Johnston JM; University of Alabama at Birmingham, Children's of Alabama, Birmingham, AL, USA., Fangusaro JR; Children's Healthcare of Atlanta, Atlanta, GA, USA., Miller M; Doernbecher Children's Hospital at Oregon Health & Science University (OHSU), Portland, OR, USA., Wood MD; Doernbecher Children's Hospital at Oregon Health & Science University (OHSU), Portland, OR, USA., Gardner S; Hassenfeld Children's Hospital at NYU Langone, New York, NY, USA., Carter CL; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Prolo LM; Lucille Packard Children's Hospital Stanford, Stanford, CA, USA., Pisapia J; Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, USA., Pehlivan K; Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, USA., Franson A; C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA., Niazi T; Nicklaus Children's Hospital, Miami, FL, USA., Rubin J; St. Louis Children's Hospital, St. Louis, MO., Abdelbaki M; St. Louis Children's Hospital, St. Louis, MO., Ziegler DS; Kids Cancer Centre, Sydney Children's Hospital, High St, Randwick, NSW, Australia; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia., Lindsay HB; Texas Children's Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, USA., Stucklin AG; University Children's Zürich, Zürich, Switzerland., Gerber N; University Children's Zürich, Zürich, Switzerland., Vaske OM; University of California Santa Cruz, Santa Cruz, CA, USA., Quinsey C; UNC Chapel Hill, Chapel Hill, NC, USA; North Carolina Children's Hospital, Chapel Hill, NC, USA., Rood BR; Children's National Hospital, Washington, DC, USA., Nazarian J; University Children's Zürich, Zürich, Switzerland; Center for Genetic Medicine Research, Children's National Hospital, Washington, DC, USA; The George Washington University School of Medicine and Health Sciences, Washington, DC, USA., Raabe E; Johns Hopkins University School of Medicine, Baltimore, MD USA., Jackson EM; Johns Hopkins University School of Medicine, Baltimore, MD USA., Stapleton S; Johns Hopkins University School of Medicine, Baltimore, MD USA., Lober RM; Dayton Children's Hospital, Dayton, OH, USA., Kram DE; UNC Chapel Hill, Chapel Hill, NC, USA; North Carolina Children's Hospital, Chapel Hill, NC, USA., Koschmann C; C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA., Storm PB; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Lulla RR; Hasbro Children's Hospital, Brown University., Prados M; University of California San Francisco Benioff Children's Hospital, San Franscisco, CA, USA., Resnick AC; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Waanders AJ; Ann and Robert Lurie Children's Hospital, Chicago, IL, USA. Electronic address: awaanders@luriechildrens.org. |
| المصدر: | Neoplasia (New York, N.Y.) [Neoplasia] 2023 Jan; Vol. 35, pp. 100846. Date of Electronic Publication: 2022 Nov 03. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : [Amsterdam] : Elsevier Original Publication: New York, NY : Stockton Press, c1999- |
| مواضيع طبية MeSH: | Quality of Life* , Brain Neoplasms*/therapy, Adult ; Humans ; Child |
| مستخلص: | Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for > 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. David S. Ziegler is a consultant, or on the advisory board, of Bayer, AstraZeneca, Accendatech, Novartis, Day One, FivePhusion, Amgen, Alexion, and Norgine. Angela J. Waanders is on the advisory board of Alexion and Day One. (Copyright © 2022. Published by Elsevier Inc.) |
| معلومات مُعتمدة: | U2C HD109731 United States HD NICHD NIH HHS; UL1 TR002384 United States TR NCATS NIH HHS |
| فهرسة مساهمة: | Keywords: Biospecimens; Collaborative international research infrastructure; Longitudinal clinical data; Molecular clinical trials; Multi-omic data; Pediatric brain tumors |
| تواريخ الأحداث: | Date Created: 20221106 Date Completed: 20221220 Latest Revision: 20240423 |
| رمز التحديث: | 20240423 |
| مُعرف محوري في PubMed: | PMC9641002 |
| DOI: | 10.1016/j.neo.2022.100846 |
| PMID: | 36335802 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1476-5586 |
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| DOI: | 10.1016/j.neo.2022.100846 |