دورية أكاديمية
The toxicological effects of Eryngium foetidum extracts on zebrafish embryos and larvae depend on the type of extract, dose, and exposure time.
| العنوان: | The toxicological effects of Eryngium foetidum extracts on zebrafish embryos and larvae depend on the type of extract, dose, and exposure time. |
|---|---|
| المؤلفون: | Castro TFD; Faculty of Animal Science and Veterinary Medicine, Department of Veterinary Medicine, Federal University of Lavras, Lavras, MG, CEP:37200-000, Brazil., Carneiro WF; Faculty of Animal Science and Veterinary Medicine, Department of Veterinary Medicine, Federal University of Lavras, Lavras, MG, CEP:37200-000, Brazil., Reichel T; School of Agricultural Sciences, Department of Agriculture, Federal University of Lavras, Lavras, MG, Brasil., Fabem SL; Faculty of Animal Science and Veterinary Medicine, Department of Veterinary Medicine, Federal University of Lavras, Lavras, MG, CEP:37200-000, Brazil., Machado MRF; Department of Biological Sciences, Federal University of Jataí, Jataí, GO, CEP: 75801-615, Brasil., de Souza KKC; School of Agricultural Sciences, Department of Agriculture, Federal University of Lavras, Lavras, MG, Brasil., Resende LV; School of Agricultural Sciences, Department of Agriculture, Federal University of Lavras, Lavras, MG, Brasil., Murgas LDS; Faculty of Animal Science and Veterinary Medicine, Department of Veterinary Medicine, Federal University of Lavras, Lavras, MG, CEP:37200-000, Brazil. |
| المصدر: | Toxicology research [Toxicol Res (Camb)] 2022 Oct 03; Vol. 11 (5), pp. 891-899. Date of Electronic Publication: 2022 Oct 03 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101587950 Publication Model: eCollection Cited Medium: Print ISSN: 2045-452X (Print) Linking ISSN: 2045452X NLM ISO Abbreviation: Toxicol Res (Camb) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : Oxford : Oxford University Press Original Publication: Cambridge : RSC Publishing |
| مستخلص: | Eryngium foetidum is a herbaceous plant found in tropical and subtropical regions. In vivo pharmacological parameters show that leaf extracts of this plant have antioxidant, anti-inflammatory, antidiabetic, and antimicrobial activities due to their bioactive compounds such as flavonoids and phenols. Despite the evidence for several bioactivities of E. foetidum , information on its safety and tolerability is limited. The objective of this study was to assess the effect and concentration of different extracts of E. foetidum on the development of zebrafish ( Danio rerio ) embryos. To study the impact of aqueous (AE), ethanolic (EE), and methanolic (ME) extracts, the embryos were exposed to 0.625, 1.25, 2.5, 5, and 10 mg mL -1 for up to 120-h postfertilization to assess embryonic developmental toxicity and then to 0.039, 0.078, 0.156, 0.312, and 0.625 mg mL -1 to assess the antioxidant responses of the enzymes superoxide dismutase catalase, glutathione S-transferase (GST), and cell apoptosis. The results showed that, depending on the extraction solvent, concentration used, and exposure time, E. foetidum extracts caused mortality, altered the hatching time, and promoted changes in enzymatic activities. Delays in development and increased GST activity were found in all treatments. Apoptosis was not observed in any of the treatments. In conclusion, AE, EE, and ME concentrations above 0.625 mg mL -1 can cause adverse effects on the early stages of zebrafish development. (© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.) |
| References: | Int J Mol Sci. 2017 Apr 04;18(4):. (PMID: 28375163) Anal Biochem. 1976 May 7;72:248-54. (PMID: 942051) Toxicol Sci. 2009 Oct;111(2):202-25. (PMID: 19567883) Heliyon. 2020 Jun 02;6(6):e04086. (PMID: 32514483) Pharmaceuticals (Basel). 2019 Nov 30;12(4):. (PMID: 31801207) Molecules. 2020 Feb 19;25(4):. (PMID: 32092874) Methods Enzymol. 1981;77:398-405. (PMID: 7329316) Toxicol Res (Camb). 2017 Mar 29;6(4):460-467. (PMID: 30090514) J Ethnobiol Ethnomed. 2007 Mar 15;3:13. (PMID: 17362507) Chem Res Toxicol. 2006 Nov;19(11):1499-505. (PMID: 17112238) Ecotoxicol Environ Saf. 2010 Nov;73(8):1862-6. (PMID: 20832863) Ecotoxicol Environ Saf. 2020 Apr 1;192:110321. (PMID: 32061978) Fish Shellfish Immunol. 2019 Mar;86:549-558. (PMID: 30517881) Fitoterapia. 2011 Apr;82(3):302-8. (PMID: 21062639) J Ethnobiol Ethnomed. 2018 Jun 20;14(1):43. (PMID: 29925407) Asian Pac J Cancer Prev. 2012;13(7):3343-7. (PMID: 22994758) Carbohydr Polym. 2019 Oct 1;221:73-83. (PMID: 31227169) Environ Sci Pollut Res Int. 2018 Dec;25(35):35015-35026. (PMID: 30357668) Evid Based Complement Alternat Med. 2019 Mar 5;2019:3807207. (PMID: 30949217) Toxicol Res. 2016 Jul;32(3):231-7. (PMID: 27437090) Toxicol Rep. 2019 Oct 25;6:1148-1154. (PMID: 31993329) Int J Mol Sci. 2017 Nov 28;18(12):. (PMID: 29182587) J Nutr. 2003 Oct;133(10):3248S-3254S. (PMID: 14519822) Int J Food Sci Nutr. 2011 Nov;62(7):765-73. (PMID: 21615278) Cancer Lett. 2018 Oct 1;433:33-42. (PMID: 29959055) Biochim Biophys Acta Gen Subj. 2020 Aug;1864(8):129634. (PMID: 32417171) Aquat Toxicol. 2021 Jul 30;238:105928. (PMID: 34358787) Fish Shellfish Immunol. 2019 Dec;95:399-410. (PMID: 31654769) Chemosphere. 2020 Sep;255:126889. (PMID: 32388256) Dis Model Mech. 2014 Jul;7(7):739-43. (PMID: 24973743) Aquat Toxicol. 2015 Jan;158:50-62. (PMID: 25461745) Environ Toxicol. 2011 Oct;26(5):480-8. (PMID: 20549606) Biochim Biophys Acta. 2011 Oct;1807(10):1295-304. (PMID: 21718686) Chemosphere. 2019 Feb;217:629-635. (PMID: 30447611) Fitoterapia. 2011 Jun;82(4):513-23. (PMID: 21277359) Chemosphere. 2018 Jan;191:106-117. (PMID: 29031050) |
| فهرسة مساهمة: | Keywords: Danio rerio; antioxidant enzymes; apoptosis; development |
| تواريخ الأحداث: | Date Created: 20221107 Latest Revision: 20231004 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9618102 |
| DOI: | 10.1093/toxres/tfac067 |
| PMID: | 36337237 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2045-452X |
|---|---|
| DOI: | 10.1093/toxres/tfac067 |