دورية أكاديمية
Obesity, but not glycemic control, predicts liver steatosis in children with type 1 diabetes.
| العنوان: | Obesity, but not glycemic control, predicts liver steatosis in children with type 1 diabetes. |
|---|---|
| المؤلفون: | Tas E; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Endocrinology and Diabetes, Arkansas Children's Hospital, Little Rock, AR, USA; Arkansas Children's Nutrition Center, Little Rock, AR, USA; Arkansas Children's Research Institute, Little Rock, AR, USA. Electronic address: etas@uams.edu., Bai S; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Mak D; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Endocrinology and Diabetes, Arkansas Children's Hospital, Little Rock, AR, USA., Diaz EC; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Arkansas Children's Nutrition Center, Little Rock, AR, USA; Arkansas Children's Research Institute, Little Rock, AR, USA., Dranoff JA; Arkansas Children's Research Institute, Little Rock, AR, USA; VA Connecticut Health Center, West Haven, CT, USA; Secton of Digestive Diseases, Yale School of Medicine, New Haven, CT, USA. |
| المصدر: | Journal of diabetes and its complications [J Diabetes Complications] 2022 Dec; Vol. 36 (12), pp. 108341. Date of Electronic Publication: 2022 Oct 25. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Pub. Co Country of Publication: United States NLM ID: 9204583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-460X (Electronic) Linking ISSN: 10568727 NLM ISO Abbreviation: J Diabetes Complications Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier Science Pub. Co., c1992- |
| مواضيع طبية MeSH: | Non-alcoholic Fatty Liver Disease*/diagnosis , Non-alcoholic Fatty Liver Disease*/diagnostic imaging , Diabetes Mellitus, Type 1*/complications, Humans ; Child ; Cross-Sectional Studies ; Obesity/complications ; Obesity/epidemiology ; Body Mass Index ; Cholesterol, HDL ; Liver |
| مستخلص: | Objective: Nonalcoholic fatty liver disease (NAFLD), the most common liver disease in children, is strongly associated with obesity and insulin resistance. Although type 1 diabetes (T1D) is characterized by insulin deficiency, increasing obesity rates among children with T1D is a major risk factor for NAFLD in this patient population. Predisposing factors for NAFLD in children with T1D are not known. Study Design: This is a cross-sectional study comparing children with T1D across the range of body mass index (BMI) to the BMI-matched obese group without T1D. Hepatic steatosis was semi-quantitatively measured via the vibration-controlled transient elastogram (VCTE) method. Linear regression analysis was performed to assess the relationship between controlled-attenuated parameter (CAP) scores and clinical parameters. Receiver-operator curve (ROC) analysis was used to evaluate the diagnostic performance of several clinical parameters against NAFLD status determined via CAP. Results: Two-thirds of subjects with obesity had CAP scores suggestive of NAFLD, while 16 % (n = 6) of T1D patients without obesity had elevated CAP. Obese subjects were different from non-obese subjects in many laboratory and clinical characteristics, regardless of T1D status. CAP score was significantly associated with BMI, HDL-Cholesterol (HDL-c), and HbA1c in all subjects as well as the T1D-only subgroup. Among subjects with obesity only, age, HDL-cand ALT were the most significant predictors. Diagnostic performance of BMI, HDL-c, and BMI/HDL ratio were in the good to the excellent range for predicting NAFLD among all subjects, while performance varied for T1D-only or obesity-only groups. Conclusion: The clinical and imaging findings of children with T1D and obesity are comparable to non-diabetic children with a similar degree of obesity. Obesity is the major risk factor for NAFLD in pediatric T1D. BMI, HDL-c, and BMI/HDL ratio may be helpful markers to determine further workup for NAFLD in children with T1D, particularly those with obesity. Competing Interests: Declaration of competing interest None declared. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: J Diabetes Complications. 2022 Dec;36(12):108359. (PMID: 36446208) |
| فهرسة مساهمة: | Keywords: Control-attenuated parameter; Hemoglobin A1c; NAFLD; Receiver-operator curve; Vibration-controlled transient elastogram |
| المشرفين على المادة: | 0 (Cholesterol, HDL) |
| تواريخ الأحداث: | Date Created: 20221108 Date Completed: 20221206 Latest Revision: 20221220 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jdiacomp.2022.108341 |
| PMID: | 36345110 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-460X |
|---|---|
| DOI: | 10.1016/j.jdiacomp.2022.108341 |