دورية أكاديمية
أعرض في EDS

Cytokines in Lung Transplantation.

التفاصيل البيبلوغرافية
العنوان: Cytokines in Lung Transplantation.
المؤلفون: Assadiasl S; Molecular Immunology Research Center, Tehran University of Medical Sciences, No. 142, Nosrat St., Tehran, 1419733151, Iran. assadiasl@sina.tums.ac.ir., Nicknam MH; Molecular Immunology Research Center, Tehran University of Medical Sciences, No. 142, Nosrat St., Tehran, 1419733151, Iran.; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
المصدر: Lung [Lung] 2022 Dec; Vol. 200 (6), pp. 793-806. Date of Electronic Publication: 2022 Nov 08.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7701875 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1750 (Electronic) Linking ISSN: 03412040 NLM ISO Abbreviation: Lung Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer Verlag
Original Publication: Heidelberg, Springer International.
مواضيع طبية MeSH: Lung Transplantation*/adverse effects , Bronchiolitis Obliterans*/etiology , Bronchiolitis Obliterans*/prevention & control, Humans ; Cytokines/genetics ; Graft Rejection/genetics ; Graft Rejection/prevention & control ; Transplantation, Homologous
مستخلص: Lung transplantation has developed significantly in recent years, but post-transplant care and patients' survival still need to be improved. Moreover, organ shortage urges novel modalities to improve the quality of unsuitable lungs. Cytokines, the chemical mediators of the immune system, might be used for diagnostic and therapeutic purposes in lung transplantation. Cytokine monitoring pre- and post-transplant could be applied to the prevention and early diagnosis of injurious inflammatory events including primary graft dysfunction, acute cellular rejection, bronchiolitis obliterans syndrome, restrictive allograft syndrome, and infections. In addition, preoperative cytokine removal, specific inhibition of proinflammatory cytokines, and enhancement of anti-inflammatory cytokines gene expression could be considered therapeutic options to improve lung allograft survival. Therefore, it is essential to describe the cytokines alteration during inflammatory events to gain a better insight into their role in developing the abovementioned complications. Herein, cytokine fluctuations in lung tissue, bronchoalveolar fluid, peripheral blood, and exhaled breath condensate in different phases of lung transplantation have been reviewed; besides, cytokine gene polymorphisms with clinical significance have been summarized.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Bronchiolitis obliterans; Cytokines; Graft rejection; Lung transplantation; Primary graft dysfunction
المشرفين على المادة: 0 (Cytokines)
تواريخ الأحداث: Date Created: 20221108 Date Completed: 20221122 Latest Revision: 20221228
رمز التحديث: 20231215
DOI: 10.1007/s00408-022-00588-1
PMID: 36348053
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1750
DOI:10.1007/s00408-022-00588-1