دورية أكاديمية
Nanoparticles Containing Tamarind Isolate Protein Potentiate the Satiety without Promoting the Anti-Inflammatory Effect in a Preclinical Model of Diet-Induced Obesity.
العنوان: | Nanoparticles Containing Tamarind Isolate Protein Potentiate the Satiety without Promoting the Anti-Inflammatory Effect in a Preclinical Model of Diet-Induced Obesity. |
---|---|
المؤلفون: | Costa ROA; Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., Medeiros I; Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., De Queiroz JLC; Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., Matias LLR; Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., Lima MSR; Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., Oliveira GS; Nutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., Aguiar AJFC; Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., Costa IS; Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., Silva EMS; Nutrition Course, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., Dos Santos NCS; Nutrition Course, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., Passos TS; Nutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.; Department of Nutrition, Federal University of Rio Grande do Norte, Natal, 59078-970, RN, Brazil., De A Morais AH; Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.; Nutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.; Department of Nutrition, Federal University of Rio Grande do Norte, Natal, 59078-970, RN, Brazil. |
المصدر: | Foods (Basel, Switzerland) [Foods] 2022 Nov 05; Vol. 11 (21). Date of Electronic Publication: 2022 Nov 05. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101670569 Publication Model: Electronic Cited Medium: Print ISSN: 2304-8158 (Print) Linking ISSN: 23048158 NLM ISO Abbreviation: Foods Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2012]- |
مستخلص: | The study aimed to evaluate the nanoparticles (ECW) containing tamarind trypsin inhibitor (TTI) concerning the storage effect under different conditions on antitrypsin activity and the bioactive potential in a preclinical model. ECW was exposed to different pH and temperatures to evaluate the interaction between TTI and its encapsulating agents, monitored by antitrypsin activity. Wistar rats (n = 25) with obesity induced by diet were divided into groups: untreated; treatment with nutritionally adequate diet; treatment with nutritionally adequate diet and ECW/12.5 mg/kg; treatment with ECW/12.5 mg/kg; and treatment with TTI/25 mg/kg. The groups were evaluated over ten days with regards to satiety, zoometric, biochemical, and inflammatory parameters, using ten times less TTI (2.5 mg/kg) contained in ECW. TTI was protected and encapsulated in ECW without showing residual inhibitory activity. Only at gastric pH did ECW show antitrypsin activity. At different temperatures, it showed high antitrypsin activity, similar to TTI. The animals treated with ECW had significantly reduced body weight variation (p < 0.05), and only TTI treatment reduced the inflammatory parameters significantly (p < 0.05). The study showed that by using lower concentrations of TTI in ECW it was possible to perceive promising effects with perspectives of use in functional products for managing obesity and its complications. |
References: | Adv Colloid Interface Sci. 2018 Mar;253:1-22. (PMID: 29478671) Int J Mol Sci. 2021 Sep 15;22(18):. (PMID: 34576130) Nutrients. 2019 Nov 14;11(11):. (PMID: 31739532) J Enzyme Inhib Med Chem. 2016 Dec;31(6):1261-9. (PMID: 26928305) Nutrients. 2021 Feb 16;13(2):. (PMID: 33669189) PLoS Biol. 2010 Jun 29;8(6):e1000412. (PMID: 20613859) Crit Rev Food Sci Nutr. 2016 Jul 3;56(9):1545-67. (PMID: 25607526) Brain Behav Immun. 2017 Jan;59:158-172. (PMID: 27592562) J Enzyme Inhib Med Chem. 2021 Dec;36(1):480-490. (PMID: 33491503) Lab Anim. 2007 Jan;41(1):111-9. (PMID: 17234057) Diabetes Metab Syndr Obes. 2020 Sep 30;13:3421-3431. (PMID: 33061503) Nutrients. 2016 Sep 27;8(10):. (PMID: 27690087) J Enzyme Inhib Med Chem. 2019 Dec;34(1):405-419. (PMID: 30734596) Clinics (Sao Paulo). 2015 Feb;70(2):136-43. (PMID: 25789523) Mol Nutr Food Res. 2009 Aug;53(8):952-8. (PMID: 19603399) Biosci Rep. 2018 Jun 27;38(3):. (PMID: 29950343) Eur J Pharm Biopharm. 2017 Jun;115:257-267. (PMID: 28336368) J Enzyme Inhib Med Chem. 2018 Dec;33(1):334-348. (PMID: 29322840) Nature. 1970 Aug 15;227(5259):680-5. (PMID: 5432063) Biochem Biophys Res Commun. 2020 Nov 26;533(1):181-187. (PMID: 32958248) Foods. 2022 Jul 25;11(15):. (PMID: 35892791) Obes Facts. 2021;14(4):357-369. (PMID: 34256373) Nat Protoc. 2019 Apr;14(4):991-1014. (PMID: 30886367) J Agric Food Chem. 2014 Jan 22;62(3):733-41. (PMID: 24364622) Biosci Biotechnol Biochem. 2012;76(6):1104-9. (PMID: 22790930) Diabetologia. 1985 Jul;28(7):412-9. (PMID: 3899825) PLoS One. 2013 Sep 10;8(9):e74743. (PMID: 24040333) |
معلومات مُعتمدة: | 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior; 426116/2018-6 National Council for Scientific and Technological Development |
فهرسة مساهمة: | Keywords: antitrypsin activity; encapsulation; pH conditions; tamarind; thermal treatment; trypsin inhibitor |
تواريخ الأحداث: | Date Created: 20221111 Latest Revision: 20230308 |
رمز التحديث: | 20230309 |
مُعرف محوري في PubMed: | PMC9658257 |
DOI: | 10.3390/foods11213526 |
PMID: | 36360138 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2304-8158 |
---|---|
DOI: | 10.3390/foods11213526 |