دورية أكاديمية
أعرض في EDS

Intra-Patient Evolution of HIV-2 Molecular Properties.

التفاصيل البيبلوغرافية
العنوان: Intra-Patient Evolution of HIV-2 Molecular Properties.
المؤلفون: Palm AA; Department of Laboratory Medicine, Lund University, 22184 Lund, Sweden.; Department of Translational Medicine, Lund University, 20502 Lund, Sweden., Esbjörnsson J; Department of Translational Medicine, Lund University, 20502 Lund, Sweden.; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK., Kvist A; Department of Clinical Sciences, Lund University, 22184 Lund, Sweden., Månsson F; Department of Translational Medicine, Lund University, 20502 Lund, Sweden., Biague A; National Public Health Laboratory, Bissau 1041, Guinea-Bissau., Norrgren H; Department of Clinical Sciences, Lund University, 22184 Lund, Sweden., Jansson M; Department of Laboratory Medicine, Lund University, 22184 Lund, Sweden., Medstrand P; Department of Translational Medicine, Lund University, 20502 Lund, Sweden.
المصدر: Viruses [Viruses] 2022 Nov 04; Vol. 14 (11). Date of Electronic Publication: 2022 Nov 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: HIV-1*/genetics , HIV Seropositivity* , HIV Infections*, Humans ; HIV-2/genetics ; Glycosylation ; Disease Progression ; Evolution, Molecular
مستخلص: Limited data are available on the pathogenesis of HIV-2, and the evolution of Env molecular properties during disease progression is not fully elucidated. We investigated the intra-patient evolution of molecular properties of HIV-2 Env regions (V1-C3) during the asymptomatic, treatment-naïve phase of the infection in 16 study participants, stratified into faster or slower progressors. Most notably, the rate of change in the number of potential N-linked glycosylation sites (PNGS) within the Env (V1-C3) regions differed between progressor groups. With declining CD4 + T-cell levels, slower progressors showed, on average, a decrease in the number of PNGSs, while faster progressors showed no significant change. Furthermore, diversity increased significantly with time in faster progressors, whereas no such change was observed in slower progressors. No differences were identified between the progressor groups in the evolution of length or charge of the analyzed Env regions. Predicted virus CXCR4 use was rare and did not emerge as a dominating viral population during the studied disease course (median 7.9 years, interquartile range [IQR]: 5.2-14.0) in either progressor groups. Further work building on our observations may explain molecular hallmarks of HIV-2 disease progression and differences in pathogenesis between HIV-1 and HIV-2.
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فهرسة مساهمة: Keywords: HIV-1; HIV-2; PNGS; coreceptor; disease progression; evolution; molecular properties
تواريخ الأحداث: Date Created: 20221111 Date Completed: 20221114 Latest Revision: 20230130
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9698092
DOI: 10.3390/v14112447
PMID: 36366545
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4915
DOI:10.3390/v14112447