دورية أكاديمية
Combined Short-Pulse and Directional Deep Brain Stimulation of the Thalamic Ventral Intermediate Area for Essential Tremor.
| العنوان: | Combined Short-Pulse and Directional Deep Brain Stimulation of the Thalamic Ventral Intermediate Area for Essential Tremor. |
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| المؤلفون: | Hidding U; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: u.hidding@uke.de., Lezius S; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schaper M; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Buhmann C; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Gerloff C; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Pötter-Nerger M; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hamel W; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Moll CKE; Department of Neurophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Choe CU; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. |
| المصدر: | Neuromodulation : journal of the International Neuromodulation Society [Neuromodulation] 2023 Dec; Vol. 26 (8), pp. 1680-1688. Date of Electronic Publication: 2022 Nov 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 9804159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1403 (Electronic) Linking ISSN: 10947159 NLM ISO Abbreviation: Neuromodulation Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [New York] : Elsevier Original Publication: Malden, MA : Blackwell Science, c1998- |
| مواضيع طبية MeSH: | Essential Tremor*/therapy , Deep Brain Stimulation*/adverse effects, Humans ; Tremor/therapy ; Paresthesia/etiology ; Paresthesia/therapy ; Thalamus/physiology ; Ataxia/etiology ; Treatment Outcome |
| مستخلص: | Objective: Novel deep brain stimulation (DBS) systems allow directional and short-pulse stimulation to potentially improve symptoms and reduce side effects. The aim of this study was to investigate the effect of short-pulse and directional stimulation, in addition to a combination of both, in the ventral intermediate thalamus (VIM)/posterior subthalamic area (PSA) on tremor and stimulation-induced side effects in patients with essential tremor. Materials and Methods: We recruited 11 patients with essential tremor and VIM/PSA-DBS. Tremor severity (Fahn-Tolosa-Marin), ataxia (International Cooperative Ataxia Rating Scale), and paresthesia (visual analog scale) were assessed with conventional omnidirectional and directional stimulation with pulse width of 60 μs and 30 μs. Results: All stimulation conditions reduced tremor. The best directional stimulation with 60 μs reduced more tremor than did most other stimulation settings. The best directional stimulation, regardless of pulse width, effectively reduced stimulation-induced ataxia compared with the conventional stimulation (ring 60 μs) or worst directional stimulation with 60 μs. All new stimulation modes reduced occurrence of paresthesia, but only the best directional stimulation with 30 μs attenuated paresthesia compared with the conventional stimulation (ring 60 μs) or worst directional stimulation with 60 μs. The best directional stimulation with 30 μs reduced tremor, ataxia, and paresthesia compared with conventional stimulation in most patients. Correlation analyses indicated that more anterior stimulation sites are associated with stronger ataxia reduction with directional 30 μs than with conventional 60 μs stimulation. Conclusion: Directional and short-pulse stimulation, and a combination of both, revealed beneficial effects on stimulation-induced adverse effects. (Copyright © 2022 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Deep brain stimulation; PSA; VIM; subthalamic area |
| تواريخ الأحداث: | Date Created: 20221111 Date Completed: 20231216 Latest Revision: 20231216 |
| رمز التحديث: | 20231217 |
| DOI: | 10.1016/j.neurom.2022.09.009 |
| PMID: | 36369082 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1525-1403 |
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| DOI: | 10.1016/j.neurom.2022.09.009 |