دورية أكاديمية
Seroprevalence, co-infection and risk of transmission of Hepatitis B and D virus among hospital attendees in two South-western states in Nigeria.
| العنوان: | Seroprevalence, co-infection and risk of transmission of Hepatitis B and D virus among hospital attendees in two South-western states in Nigeria. |
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| المؤلفون: | Sobajo OA; Department of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Nigeria.; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria.; Department of Biological Sciences, Afe Babalola University, Ado-Ekiti, Nigeria., George UE; Department of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Nigeria.; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria., Osasona OG; Department of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Nigeria.; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria., Eromon P; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria., Aborisade OY; Haematology and Blood Transfusion Service Department, UNIOSUN Teaching Hospital, Osogbo, Nigeria., Ajayi OD; Department of Medical Laboratory Science, Afe Babalola University, Ado-Ekiti, Nigeria., Folarin OA; Department of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Nigeria.; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria., Komolafe IOO; Department of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Nigeria. |
| المصدر: | Journal of immunoassay & immunochemistry [J Immunoassay Immunochem] 2023 Mar 04; Vol. 44 (2), pp. 133-146. Date of Electronic Publication: 2022 Nov 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 100963688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-4230 (Electronic) Linking ISSN: 15321819 NLM ISO Abbreviation: J Immunoassay Immunochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Abingdon, Oxford : Taylor & Francis Original Publication: New York, NY : Marcel Dekker, 2001- |
| مواضيع طبية MeSH: | Hepatitis D*/epidemiology , Coinfection* , Hepatitis B*/epidemiology, Humans ; Hepatitis B Surface Antigens ; Hepatitis delta Antigens ; Seroepidemiologic Studies ; Nigeria/epidemiology ; Cross-Sectional Studies ; Hepatitis B virus ; Hospitals ; Immunoglobulin M ; Immunoglobulin G ; Prevalence |
| مستخلص: | Infection with both Hepatitis B (HBV) and D (HDV) virus causes more severe liver damage than HBV alone. Superinfections among chronic HBV infected cohorts often lead to HDV persistence with rapid progression to cirrhosis, necessitating continuous surveillance to determine their prevalence and relative contribution to liver pathology. A cross-sectional study among hospital outpatients in Ekiti and Osunstates was conducted using random sampling technique. Blood samples were collected from 410 participants and tested for HBV serological markers. All samples positive for HBsAg samples were tested for Hepatitis D virus antigen (HDAg), serum anti-HDV IgM, and serum anti-HDV IgG using enzyme-linked immunosorbent assay kits. The prevalence of HBV infection among the 410 samples was 12.4% (CI 9.5-15.9). Past HBV exposure was detected in 120 (29.2%), while 147(35.8%) were susceptible to HBV infection. Among the HBsAg positive individuals, 9.8% were hepatitis D antigen (HDAg) positive, while 3.9% and 1.9% were positive for IgG anti-HDV and IgM anti-HDV, respectively. Risk factors associated with HBV infections in this study were multiple sexual partners and sharing of sharp objects. Our investigation has verified the endemicity of HBV in Nigeria and revealed that HBV- HDV co-infection is highly prevalent in south-west Nigeria. |
| فهرسة مساهمة: | Keywords: HBV/HDV prevalence; Nigeria; co-infection; risk factor |
| المشرفين على المادة: | 0 (Hepatitis B Surface Antigens) 0 (Hepatitis delta Antigens) 0 (Immunoglobulin M) 0 (Immunoglobulin G) |
| تواريخ الأحداث: | Date Created: 20221112 Date Completed: 20230307 Latest Revision: 20230307 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/15321819.2022.2141578 |
| PMID: | 36369932 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-4230 |
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| DOI: | 10.1080/15321819.2022.2141578 |