دورية أكاديمية
أعرض في EDS

In vivo T 1 mapping of neonatal brain tissue at 64 mT.

التفاصيل البيبلوغرافية
العنوان: In vivo T 1 mapping of neonatal brain tissue at 64 mT.
المؤلفون: Padormo F; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.; Medical Physics, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom.; Hyperfine, Inc., Guilford, Connecticut, USA., Cawley P; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.; Medical Research Council Center for Neurodevelopmental Disorders, King's College London, London, United Kingdom.; Department of Neonatology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom., Dillon L; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom., Hughes E; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom., Almalbis J; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.; Department of Neonatology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom., Robinson J; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.; Department of Neonatology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom., Maggioni A; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.; Department of Neonatology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom., Botella MF; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.; Department of Neonatology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom., Cromb D; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.; Department of Neonatology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom., Price A; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.; Medical Physics, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom., Arlinghaus L; Hyperfine, Inc., Guilford, Connecticut, USA., Pitts J; Hyperfine, Inc., Guilford, Connecticut, USA., Luo T; Hyperfine, Inc., Guilford, Connecticut, USA., Zhang D; Hyperfine, Inc., Guilford, Connecticut, USA., Deoni SCL; Advanced Baby Imaging Lab, Rhode Island Hospital, Warren, Alpert Medical School at Brown University, Providence, Rhode Island, USA.; Department of Diagnostic Radiology, Warren Alpert Medical School at Brown University, Providence, Rhode Island, USA.; Department of Pediatrics, Warren Alpert Medical School at Brown University, Providence, Rhode Island, USA., Williams S; Medical Research Council Center for Neurodevelopmental Disorders, King's College London, London, United Kingdom.; Center for Neuroimaging Sciences, King's College London, London, United Kingdom., Malik S; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom., O Muircheartaigh J; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.; Medical Research Council Center for Neurodevelopmental Disorders, King's College London, London, United Kingdom.; Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom., Counsell SJ; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom., Rutherford M; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.; Medical Research Council Center for Neurodevelopmental Disorders, King's College London, London, United Kingdom., Arichi T; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.; Medical Research Council Center for Neurodevelopmental Disorders, King's College London, London, United Kingdom.; Department of Bioengineering, Imperial College London, London, United Kingdom.; Pediatric Neurosciences, Evelina London Children's Hospital, Guys' and St. Thomas' NHS Foundation Trust, London, United Kingdom., Edwards AD; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.; Medical Research Council Center for Neurodevelopmental Disorders, King's College London, London, United Kingdom.; Department of Neonatology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom., Hajnal JV; Center for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom.
المصدر: Magnetic resonance in medicine [Magn Reson Med] 2023 Mar; Vol. 89 (3), pp. 1016-1025. Date of Electronic Publication: 2022 Nov 13.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 8505245 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-2594 (Electronic) Linking ISSN: 07403194 NLM ISO Abbreviation: Magn Reson Med Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : New York, NY : Wiley
Original Publication: San Diego : Academic Press,
مواضيع طبية MeSH: Brain*/diagnostic imaging , White Matter*, Adult ; Infant, Newborn ; Humans ; Infant ; Magnetic Resonance Imaging/methods ; Cerebellum ; Linear Models ; Brain Mapping/methods
مستخلص: Purpose: Ultralow-field (ULF) point-of-care MRI systems allow image acquisition without interrupting medical provision, with neonatal clinical care being an important potential application. The ability to measure neonatal brain tissue T 1 is a key enabling technology for subsequent structural image contrast optimization, as well as being a potential biomarker for brain development. Here we describe an optimized strategy for neonatal T 1 mapping at ULF.
Methods: Examinations were performed on a 64-mT portable MRI system. A phantom validation experiment was performed, and a total of 33 in vivo exams were acquired from 28 neonates with postmenstrual age ranging from 31 +4 to 49 +0  weeks. Multiple inversion-recovery turbo spin-echo sequences were acquired with differing inversion and repetition times. An analysis pipeline incorporating inter-sequence motion correction generated proton density and T 1 maps. Regions of interest were placed in the cerebral deep gray matter, frontal white matter, and cerebellum. Weighted linear regression was used to predict T 1 as a function of postmenstrual age.
Results: Reduction of T 1 with postmenstrual age is observed in all measured brain tissue; the change in T 1 per week and 95% confidence intervals is given by dT 1  = -21 ms/week [-25, -16] (cerebellum), dT 1  = -14 ms/week [-18, -10] (deep gray matter), and dT 1  = -35 ms/week [-45, -25] (white matter).
Conclusion: Neonatal T 1 values at ULF are shorter than those previously described at standard clinical field strengths, but longer than those of adults at ULF. T 1 reduces with postmenstrual age and is therefore a candidate biomarker for perinatal brain development.
(© 2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)
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معلومات مُعتمدة: 206675/Z/17/Z United Kingdom WT_ Wellcome Trust; MR/P008712/1 United Kingdom MRC_ Medical Research Council; WT 203148/Z/16/Z United Kingdom WT_ Wellcome Trust; MR/W006251/1 United Kingdom MRC_ Medical Research Council; MR/V036874/1 United Kingdom MRC_ Medical Research Council; MR/N026063/1 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: gray matter; neonatal; relaxometry; ultralow-field MRI; white matter
تواريخ الأحداث: Date Created: 20221114 Date Completed: 20221228 Latest Revision: 20240320
رمز التحديث: 20240320
مُعرف محوري في PubMed: PMC10099617
DOI: 10.1002/mrm.29509
PMID: 36372971
قاعدة البيانات: MEDLINE
الوصف
تدمد:1522-2594
DOI:10.1002/mrm.29509