دورية أكاديمية
Neurobiological Mechanisms Of Depression Following Traumatic Brain Injury.
| العنوان: | Neurobiological Mechanisms Of Depression Following Traumatic Brain Injury. |
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| المؤلفون: | Jahan AB; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, US.; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, US., Tanev K; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, US. |
| المصدر: | Brain injury [Brain Inj] 2023 Jan 02; Vol. 37 (1), pp. 24-33. Date of Electronic Publication: 2022 Nov 14. |
| نوع المنشور: | Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8710358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-301X (Electronic) Linking ISSN: 02699052 NLM ISO Abbreviation: Brain Inj Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: London ; New York : Taylor & Francis, c1987- |
| مواضيع طبية MeSH: | Depression*/etiology , Brain Injuries, Traumatic*, Humans ; Brain/metabolism |
| مستخلص: | Objective: Depression is among the most pervasive and debilitating neuropsychiatric sequelae experienced by patients following a traumatic brain injury (TBI). While the individual mechanisms underlying depression and TBI have been widely studied, the neurobiological bases of depression after TBI remain largely unknown. This article highlights the potential mechanisms of action implicated in depression after TBI. Results: We review putative mechanisms of action including neuroinflammation, neuroendocrine dysregulation, metabolic abnormalities, and neurotransmitter and circuitry dysfunction. We also identify the current limitations in the field and propose directions for future research. Conclusion: An improved understanding of the underlying mechanisms will aid the development of precision-guided and personalized treatments for patients suffering from depression after TBI. |
| فهرسة مساهمة: | Keywords: TBI; Traumatic brain injury; depression; mechanisms; metabolism; neuroinflammation; neurotransmitters; post-TBI depression |
| تواريخ الأحداث: | Date Created: 20221114 Date Completed: 20221222 Latest Revision: 20230216 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/02699052.2022.2145362 |
| PMID: | 36373974 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1362-301X |
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| DOI: | 10.1080/02699052.2022.2145362 |