دورية أكاديمية
[Current insights on monitoring of renal transplants-Banff and beyond].
| العنوان: | [Current insights on monitoring of renal transplants-Banff and beyond]. |
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| عنوان ترانسليتريتد: | Aktuelle Aspekte zur Diagnostik an Nierentransplantaten – „Banff and beyond“. |
| المؤلفون: | Bräsen JH; Bereichsleitung Nephropathologie, Institut für Pathologie, OE 5110, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. braesen.jan@mh-hannover.de. |
| المصدر: | Pathologie (Heidelberg, Germany) [Pathologie (Heidelb)] 2022 Aug; Vol. 43 (Suppl 1), pp. 134-136. Date of Electronic Publication: 2022 Nov 15. |
| نوع المنشور: | English Abstract; Journal Article; Review |
| اللغة: | German |
| بيانات الدورية: | Publisher: Springer Medizin Country of Publication: Germany NLM ID: 9918384887506676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-7196 (Electronic) Linking ISSN: 27317188 NLM ISO Abbreviation: Pathologie (Heidelb) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Heidelberg, Germany] : Springer Medizin, [2022]- |
| مواضيع طبية MeSH: | Kidney Transplantation* , Transplants*, Graft Rejection ; Kidney/surgery ; Biopsy |
| مستخلص: | Renal transplantation represents the best treatment for end-stage renal disease. Much effort has been invested in improvement of longevity of the transplanted organ including a comprehensive and regularly updated histological scoring system (Banff classification) for surveillance; however, survival of transplanted kidneys is still limited to median 15 years. Molecular analyses have increased the understanding of damaging mechanisms within the transplant, especially antibody-mediated rejection, which can be difficult to identify using histological methods. Changes in the Banff classification necessitate to reclassify biopsies included in studies according to current consensus. Digital and molecular innovations as well as new immunologic mechanisms are anticipated. (© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.) |
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(PMID: 10.1016/j.ekir.2022.05.027) Zhao D, Abou-Daya KI, Dai H et al (2020) Innate allorecognition and memory in transplantation. Front Immunol 11:918. https://doi.org/10.3389/fimmu.2020.00918. (PMID: 10.3389/fimmu.2020.00918) |
| فهرسة مساهمة: | Keywords: Consensus classification; Digital pathology; Molecular pathology; Precision medicine; Rejection diagnosis Local Abstract: [Publisher, German] Die Nierentransplantation ist die beste und einzige kurative Therapie des terminalen Nierenversagens. Wesentliche Anstrengungen für die Verbesserung der Langzeitorganfunktion wurden in die Entwicklung eines umfassenden und regelmäßig aktualisierten histologischen Analysesystems investiert (Banff-Klassifikation). Trotz dieses Überwachungsinstruments ist das mittlere Organüberleben auf 15 Jahre begrenzt. Molekulare Analysen haben das Verständnis schädigender pathophysiologischer Mechanismen im Transplantat wesentlich vorangebracht, insbesondere die antikörpermediierte Rejektion, welche allein mit histologischen Methoden z. T. schwer zu erkennen ist. Mit der Fortentwicklung einhergehende Änderungen der Banff-Klassifikation machen es für die kontinuierliche Pflege von Datenbanken und für Publikationen nötig, die eingeschlossenen Biopsien nach aktuellem Konsensus nach zu beurteilen. Digitale und molekulare Innovationen sowie neue immunologische Mechanismen sind zu erwarten. |
| تواريخ الأحداث: | Date Created: 20221115 Date Completed: 20221220 Latest Revision: 20221222 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s00292-022-01148-3 |
| PMID: | 36378289 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. | تدمد: | 2731-7196 |
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| DOI: | 10.1007/s00292-022-01148-3 |