دورية أكاديمية
Anti-inflammatory and antinociceptive effects of a pectinolide-enriched fraction from Mesosphaerum pectinatum (L.) Kuntze.
| العنوان: | Anti-inflammatory and antinociceptive effects of a pectinolide-enriched fraction from Mesosphaerum pectinatum (L.) Kuntze. |
|---|---|
| المؤلفون: | Santana FR; Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, 49100-000, Brazil., de Santana Souza MT; Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, 49100-000, Brazil., Camargo EA; Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, 49100-000, Brazil., Silva JAD; Departamento de Farmácia, Universidade Federal de Sergipe, Lagarto, SE, 49400-000, Brazil. Electronic address: jamesalmada@academico.ufs.br. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2023 Feb 10; Vol. 302 (Pt B), pp. 115916. Date of Electronic Publication: 2022 Nov 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Lamiaceae* , Peritonitis*/chemically induced , Peritonitis*/drug therapy, Mice ; Animals ; Carrageenan ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Pain/chemically induced ; Pain/drug therapy ; Anti-Inflammatory Agents/adverse effects ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Edema/drug therapy ; Dexamethasone/therapeutic use |
| مستخلص: | Ethnopharmacological Relevance: Mesosphaerum pectinatum (L.) Kuntze (Lamiaceae), also known as sambacaitá, is a medicinal plant widely used in northeastern Brazil for the treatment of inflammatory and painful conditions, bacterial infections and cancer. Hence, the medicinal use of this species is quite meaningful to the search for bioactive compounds. Aim of the Study: To evaluate the antinociceptive and anti-inflammatory activities of the pectinolide-enriched fraction of Mesosphaerum pectinatum (PEF) in animal models. Materials and Methods: The PEF was analyzed with HPLC-DAD and 1 H and 13 C NMR. After the analysis, compounds of the pectinolide class were detected as major constituents in this fraction. The PEF (50, 100 and 200 mg/kg, p.o.) and the reference drugs - morphine (3.0 mg/kg, p.o.) and dexamethasone (2.0 mg/kg, p.o.) - were evaluated using models for nociception (hot plate, formalin-induced licking response) or inflammation (carrageenan-induced peritonitis and ear edema model). Results: The PEF significantly decreased the licking time of the animals treated when compared to the control group (second phase). In the carrageenan-induced peritonitis model, PEF (100 and 200 mg/kg) significantly decreased total and differential leukocyte counts. The PEF (0.3, 1.0 and 3.0 mg/ear) significantly reduced mice ear edema at the same extent and like the results obtained with the standard drug (dexamethasone). The MPO activity was reduced in mice ear at doses of 1 and 3 mg/ear. Antinociceptive effect on the hot plate test was not observed, demonstrating that there is no analgesic activity. Conclusion: Our results suggest that the pectinolide-enriched fraction exhibits anti-inflammatory effects and that it is involved with inhibiting the release of the inflammatory mediators. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Edema; Inflammation; Pectinolides; Peritonitis; Sambacaitá |
| المشرفين على المادة: | 9000-07-1 (Carrageenan) 0 (Plant Extracts) 0 (Anti-Inflammatory Agents) 0 (Analgesics) 7S5I7G3JQL (Dexamethasone) |
| تواريخ الأحداث: | Date Created: 20221115 Date Completed: 20221201 Latest Revision: 20221201 |
| رمز التحديث: | 20221201 |
| DOI: | 10.1016/j.jep.2022.115916 |
| PMID: | 36379417 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
|---|---|
| DOI: | 10.1016/j.jep.2022.115916 |