دورية أكاديمية
Visualization of exhaled breath metabolites reveals distinct diagnostic signatures for acute cardiorespiratory breathlessness.
| العنوان: | Visualization of exhaled breath metabolites reveals distinct diagnostic signatures for acute cardiorespiratory breathlessness. |
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| المؤلفون: | Ibrahim W; Department of Respiratory Sciences, University of Leicester, Leicester LE1 7RH, UK., Wilde MJ; School of Chemistry, University of Leicester, Leicester LE1 7RH, UK.; School of Geography, Earth and Environmental Sciences, University of Plymouth, Plymouth PL4 8AA, UK., Cordell RL; School of Chemistry, University of Leicester, Leicester LE1 7RH, UK., Richardson M; Department of Respiratory Sciences, University of Leicester, Leicester LE1 7RH, UK., Salman D; Department of Chemistry, Loughborough University, Loughborough LE11 3TT, UK., Free RC; Department of Respiratory Sciences, University of Leicester, Leicester LE1 7RH, UK., Zhao B; Leverhulme Centre for Demographic Science, University of Oxford, Oxford OX1 1JD, UK.; Nuffield College, University of Oxford, Oxford OX1 1NF, UK., Singapuri A; Department of Respiratory Sciences, University of Leicester, Leicester LE1 7RH, UK., Hargadon B; Department of Respiratory Sciences, University of Leicester, Leicester LE1 7RH, UK., Gaillard EA; Department of Respiratory Sciences, University of Leicester, Leicester LE1 7RH, UK., Suzuki T; Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Center, Glenfield General Hospital, Leicester LE3 9QP, UK.; Institute of Medical Science, University of Tokyo Shirokanedai, Minato-ku 4-6-1 108-8639, Tokyo, Japan., Ng LL; Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Center, Glenfield General Hospital, Leicester LE3 9QP, UK., Coats T; Emergency Medicine Academic Group, Department of Cardiovascular Sciences, University of Leicester, University Road, Leicester LE1 7RH, UK., Thomas P; Department of Chemistry, Loughborough University, Loughborough LE11 3TT, UK., Monks PS; School of Chemistry, University of Leicester, Leicester LE1 7RH, UK., Brightling CE; Department of Respiratory Sciences, University of Leicester, Leicester LE1 7RH, UK., Greening NJ; Department of Respiratory Sciences, University of Leicester, Leicester LE1 7RH, UK., Siddiqui S; Department of Respiratory Sciences, University of Leicester, Leicester LE1 7RH, UK.; National Heart and Lung Institute, Imperial College, London SW3 6LY UK., Munton R, Le Quesne J, Goodall AH, Pandya HC, Reynolds JC, Clokie MRJ, Samani NJ, Barer MR, Shaw JA |
| مؤلفون مشاركون: | EMBER Consortium |
| المصدر: | Science translational medicine [Sci Transl Med] 2022 Nov 16; Vol. 14 (671), pp. eabl5849. Date of Electronic Publication: 2022 Nov 16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Association for the Advancement of Science |
| مواضيع طبية MeSH: | Volatile Organic Compounds*/analysis , Asthma*/diagnosis , Heart Failure*/diagnosis, Humans ; Breath Tests ; Acute Disease ; Dyspnea/diagnosis ; Biomarkers/metabolism |
| مستخلص: | Acute cardiorespiratory breathlessness accounts for one in eight of all emergency hospitalizations. Early, noninvasive diagnostic testing is a clinical priority that allows rapid triage and treatment. Here, we sought to find and replicate diagnostic breath volatile organic compound (VOC) biomarkers of acute cardiorespiratory disease and understand breath metabolite network enrichment in acute disease, with a view to gaining mechanistic insight of breath biochemical derangements. We collected and analyzed exhaled breath samples from 277 participants presenting acute cardiorespiratory exacerbations and aged-matched healthy volunteers. Topological data analysis phenotypes differentiated acute disease from health and acute cardiorespiratory exacerbation subtypes (acute heart failure, acute asthma, acute chronic obstructive pulmonary disease, and community-acquired pneumonia). A multibiomarker score (101 breath biomarkers) demonstrated good diagnostic sensitivity and specificity (≥80%) in both discovery and replication sets and was associated with all-cause mortality at 2 years. In addition, VOC biomarker scores differentiated metabolic subgroups of cardiorespiratory exacerbation. Louvain clustering of VOCs coupled with metabolite enrichment and similarity assessment revealed highly specific enrichment patterns in all acute disease subgroups, for example, selective enrichment of correlated C5-7 hydrocarbons and C3-5 carbonyls in heart failure and selective depletion of correlated aldehydes in acute asthma. This study identified breath VOCs that differentiate acute cardiorespiratory exacerbations and associated subtypes and metabolic clusters of disease-associated VOCs. |
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| معلومات مُعتمدة: | United Kingdom DH_ Department of Health; MC_PC_19043 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; 204801 United Kingdom WT_ Wellcome Trust; PDF-2017-10-052 United Kingdom DH_ Department of Health; G0601369 United Kingdom MRC_ Medical Research Council; MR/N005880/1 United Kingdom MRC_ Medical Research Council |
| المشرفين على المادة: | 0 (Volatile Organic Compounds) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20221116 Date Completed: 20221118 Latest Revision: 20240607 |
| رمز التحديث: | 20240607 |
| مُعرف محوري في PubMed: | PMC7613858 |
| DOI: | 10.1126/scitranslmed.abl5849 |
| PMID: | 36383685 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.abl5849 |