دورية أكاديمية
The oldest unvaccinated Covid-19 survivors in South America.
العنوان: | The oldest unvaccinated Covid-19 survivors in South America. |
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المؤلفون: | de Castro MV; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil., Silva MVR; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil., Naslavsky MS; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil.; Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil., Scliar MO; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil.; Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil., Nunes K; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil.; Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil., Passos-Bueno MR; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil.; Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil., Castelli EC; Department of Pathology, School of Medicine, UNESP - São Paulo State University, Botucatu, São Paulo, Brazil., Magawa JY; Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil.; Instituto de Investigação em Imunologia-Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo, Brazil.; Departamento de Clínica Médica, Disciplina de Imunologia Clínica e Alergia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Adami FL; Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Moretti AIS; Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil., de Oliveira VL; Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil., Boscardin SB; Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Cunha-Neto E; Instituto de Investigação em Imunologia-Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo, Brazil.; Departamento de Clínica Médica, Disciplina de Imunologia Clínica e Alergia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Kalil J; Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil.; Instituto de Investigação em Imunologia-Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo, Brazil., Jouanguy E; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, University of Paris, Paris, France., Bastard P; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, University of Paris, Paris, France., Casanova JL; Imagine Institute, University of Paris, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Quiñones-Vega M; Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Laboratory of Proteomics (LabProt), Institute of Chemistry, LADETEC, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Sosa-Acosta P; Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Laboratory of Proteomics (LabProt), Institute of Chemistry, LADETEC, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Guedes JS; Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Laboratory of Proteomics (LabProt), Institute of Chemistry, LADETEC, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., de Almeida NP; Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Laboratory of Proteomics (LabProt), Institute of Chemistry, LADETEC, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Nogueira FCS; Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Laboratory of Proteomics (LabProt), Institute of Chemistry, LADETEC, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Domont GB; Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Santos KS; Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil.; Instituto de Investigação em Imunologia-Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo, Brazil.; Departamento de Clínica Médica, Disciplina de Imunologia Clínica e Alergia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Zatz M; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil. mayazatz@usp.br.; Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil. mayazatz@usp.br. |
المصدر: | Immunity & ageing : I & A [Immun Ageing] 2022 Nov 16; Vol. 19 (1), pp. 57. Date of Electronic Publication: 2022 Nov 16. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101235427 Publication Model: Electronic Cited Medium: Print ISSN: 1742-4933 (Print) Linking ISSN: 17424933 NLM ISO Abbreviation: Immun Ageing Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : BioMed Central, [2004]- |
مستخلص: | Background: Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated. Results: Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN. Conclusion: These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity. (© 2022. The Author(s).) |
التعليقات: | Erratum in: Immun Ageing. 2022 Dec 7;19(1):61. (PMID: 36476248) |
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فهرسة مساهمة: | Keywords: Covid-19; Elderly; SARS-CoV-2; Supercentenarians |
تواريخ الأحداث: | Date Created: 20221117 Latest Revision: 20231128 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9666972 |
DOI: | 10.1186/s12979-022-00310-y |
PMID: | 36384671 |
قاعدة البيانات: | MEDLINE |
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