دورية أكاديمية
أعرض في EDS

Drug-drug interactions among hospitalized elderly in patients at medical wards of Northwest Ethiopia's Comprehensive Specialized Hospitals: A multicenter observational study.

التفاصيل البيبلوغرافية
العنوان: Drug-drug interactions among hospitalized elderly in patients at medical wards of Northwest Ethiopia's Comprehensive Specialized Hospitals: A multicenter observational study.
المؤلفون: Dagnew SB; Clinical Pharmacy Unit, School of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Tadesse TY; Pharmacology and Toxicology Unit, School of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Zeleke MM; Pharmacology and Toxicology Unit, School of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Yiblet TG; Pharmacology and Toxicology Unit, School of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Addis GT; Social and Administrative Pharmacy Unit, School of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Mekonnen GB; Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia., Agegnew Wondm S; Clinical Pharmacy Unit, School of Pharmacy, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Negash EA; Clinical Pharmacy Unit, School of Pharmacy, College of Medicine and Health Sciences, Mizan Tepi University, Mizan Aman, Ethiopia.
المصدر: SAGE open medicine [SAGE Open Med] 2022 Nov 08; Vol. 10, pp. 20503121221135874. Date of Electronic Publication: 2022 Nov 08 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: England NLM ID: 101624744 Publication Model: eCollection Cited Medium: Print ISSN: 2050-3121 (Print) Linking ISSN: 20503121 NLM ISO Abbreviation: SAGE Open Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : SAGE Publications
مستخلص: Objective: Drug-drug interactions are of major concern due to links to untoward drug effects, hospitalizations, and serious health impacts. Elderly patients are more predisposed to drug interactions than younger patients. The present study aimed to find out the prevalence of drug-drug interactions at North West Ethiopian compressive specialized hospitals' Internal Medicine wards.
Methods: From 30 April to 30 July 2021 GC, a multicenter prospective observational study was conducted at north Ethiopian specialized hospitals. Data was collected by using a structured questionnaire adapted from different literature and medical records at the North West Ethiopian Comprehensive Specialized Hospitals' Internal Medicine wards during the study period. Thereafter checked the completeness of the collected data was checked drug-drug interactions by using Medscape. Epi data version 4.6.2 software was used as data clearance and STATA version 14.1 was used for further data analysis.
Result: A total of 389 subjects participated in the study of which more than half (55.53%) of them were female with a mean (SD) age of 68.9 ± 7.46 years. A total of 641 drug-drug interactions were detected in this investigation of which, 225(35.1%) were major, 299(46.6%) were significant interactions, and 117(18.3%) were minor interactions. Hospital stay (AOR = 5.95 CI: 3.49-10.12), retire (AOR = 6.71 CI: 1.26-35.78), 5-9 drugs (AOR = 5.30 CI: 2.91-9.67) and more than 10 drugs (AOR = 8.03 CI: 2.47-26.07) were important risk factors for drug-drug interactions.
Conclusion: The findings of this study suggest that drug-drug interactions were high among hospitalized elderly patients. The presence of polypharmacy, to be retired, and hospital stayed were all found to be strongly linked with drug-drug interactions.
Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2022.)
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فهرسة مساهمة: Keywords: Drug–drug interactions; Northwest Ethiopia; compressive specialized hospitals; elderly
تواريخ الأحداث: Date Created: 20221117 Latest Revision: 20221118
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9647268
DOI: 10.1177/20503121221135874
PMID: 36385798
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-3121
DOI:10.1177/20503121221135874