Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia.

التفاصيل البيبلوغرافية
العنوان:	Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia.
المؤلفون:	Tilahun A; Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Chekol E; Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Teklemaryam AB; Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Agidew MM; Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Tilahun Z; Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Admassu FT; Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Dagnaw N; Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Mengstie MA; Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Amsalu A; Department of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Mengistu EF; Department of Biomedical Sciences, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Akelew Y; Department of Medical Laboratory, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Asmamaw T; Department of Biochemistry, College of Health Sciences, Gondar University, Gondar, Ethiopia., Bantie B; Department of Adult Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
المصدر:	Heliyon [Heliyon] 2022 Oct 29; Vol. 8 (11), pp. e11342. Date of Electronic Publication: 2022 Oct 29 (Print Publication: 2022).
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Original Publication: London : Elsevier Ltd, [2015]-
مستخلص:	Background: Highly active anti-retroviral therapy has been reported to be associated with a number of side effects in human immunodeficiency virus patients among which dyslipidemia isa common metabolic disorder. Methods: A Hospital based comparative cross-sectional study among 228 HIV positive patients was conducted from July to August 2020. Socio-demographic and clinical data were collected using structured questionnaires. Fasting venous blood sample was collected and analyzed for Lipid profiles. EDTA sample was analyzed for CD4+ T cell determination . Anthropometric measurement was done. Data were analyzed using SPSS version 22. Independent t-test was done. Logistic and binary regression was done. Result: A total of 228 HIV patients were enrolled in the study. Prevalence of dyslipidemia in HAART naive and HAART treated patients was 61 (53.5%) and 84 (73.7%), respectively. The prevalence of Total Cholesterol ≥200 mg/dl was 50% and 30%; High density lipoprotein cholesterol <40 mg/dl was 43.8% and 36%; Low density lipoprotein cholesterol ≥130 mg/dl was 48.3% and 28.1%; and Triglyceride ≥ 150 mg/dl 59.6% and 39% among HAART treated and HAART naive, respectively. Age greater than 40 years (AOR = 3.27, 95% C.I: 1.47-7.25), blood pressure ≥140/90 (AOR = 16.13, 95% C.I: 5.81-44.75), being on HAART (AOR = 2.73, 95% C.I: 1.35-5.53) and body mass index >25 kg/m ² (AOR = 1.92, 95% C.I: 1.20-4.81) were identified as determinants of dyslipidemia. Conclusion: The mean value of lipid profile was significantly higher among HAART treated as compared to those HAART naive HIV positive clients. Competing Interests: The authors declare no conflict of interest. (© 2022 The Author(s).)
References:	Braz J Infect Dis. 2010 Mar-Apr;14(2):158-66. (PMID: 20563442) AIDS Res Ther. 2012 Oct 25;9(1):31. (PMID: 23095661) PLoS One. 2016 Mar 17;11(3):e0151911. (PMID: 26986065) BMC Cardiovasc Disord. 2015 Aug 28;15:95. (PMID: 26315756) J Int Assoc Provid AIDS Care. 2016 Mar-Apr;15(2):164-71. (PMID: 26514630) HIV Med. 2007 Jul;8(5):280-7. (PMID: 17561873) Cholesterol. 2010;2010:271504. (PMID: 21490912) Biomed Res Int. 2019 Feb 5;2019:2870647. (PMID: 30868068) BMC Public Health. 2014 Mar 07;14:236. (PMID: 24606888) PLoS One. 2018 May 21;13(5):e0197728. (PMID: 29782548) PLoS One. 2018 Aug 29;13(8):e0202944. (PMID: 30157268) J Clin Diagn Res. 2014 Oct;8(10):CC06-9. (PMID: 25478335) HIV Med. 2010 May;11(5):308-17. (PMID: 20002500) PLoS One. 2021 Apr 27;16(4):e0250328. (PMID: 33905435)
فهرسة مساهمة:	Keywords: Debre Tabor; Dyslipidemia; Ethiopia; HAART; HIV/AIDS
تواريخ الأحداث:	Date Created: 20221117 Latest Revision: 20221118
رمز التحديث:	20221213
مُعرف محوري في PubMed:	PMC9649969
DOI:	10.1016/j.heliyon.2022.e11342
PMID:	36387433
قاعدة البيانات:	MEDLINE

View record from ScienceDirect

Full Text Finder

الوصف
تدمد:	2405-8440
DOI:	10.1016/j.heliyon.2022.e11342