دورية أكاديمية
أعرض في EDS

3-MCPD exposure enhances ovarian fibrosis and reduces oocyte quality in mice.

التفاصيل البيبلوغرافية
العنوان: 3-MCPD exposure enhances ovarian fibrosis and reduces oocyte quality in mice.
المؤلفون: He QK; Medical College, Guangxi University, Nanning, Guangxi, 530004, China., Li YP; Research Laboratory of Zhuang & Yao Medicine, Guangxi International Zhuang Medicine Hospital, Nanning, Guangxi, 530021, China., Xu ZR; Translational Medicine Research Center, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, 530011, China., Wei WB; Medical College, Guangxi University, Nanning, Guangxi, 530004, China., Qiao FX; Medical College, Guangxi University, Nanning, Guangxi, 530004, China., Sun MX; Medical College, Guangxi University, Nanning, Guangxi, 530004, China., Liu YC; Medical College, Guangxi University, Nanning, Guangxi, 530004, China., Chen YZ; Medical College, Guangxi University, Nanning, Guangxi, 530004, China., Wang HL; Department of Basic Medicine, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China., Qi ZQ; Medical College, Guangxi University, Nanning, Guangxi, 530004, China., Liu Y; Medical College, Guangxi University, Nanning, Guangxi, 530004, China. Electronic address: liuyu@gxu.edu.cn.
المصدر: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2023 Jan 01; Vol. 316 (Pt 2), pp. 120662. Date of Electronic Publication: 2022 Nov 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6424 (Electronic) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ Pollut Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Barking, Essex, England : Elsevier Applied Science Publishers, c1987-
مواضيع طبية MeSH: Ovary* , alpha-Chlorohydrin*, Humans ; Mice ; Female ; Animals ; Oocytes ; Disease Models, Animal ; Iron ; Fibrosis ; Inflammation
مستخلص: 3-monochloro-1,2-propanediol (3-MCPD) is a food contaminant believed to be harmful to human health. Previous studies showed that 3-MCPD exerts toxic effects in multiple tissues, but whether 3-MCPD affects female reproductive function remained unknown. Here, using mouse gastric lavage models, we report that 3-MCPD exposure for four weeks affected body growth, decreased the ovary/body weight ratio, and increased atretic follicle numbers. Expression levels of follicular development-related factors decreased. Further studies found that ovaries from 3-MCPD exposed mice had activated the Transforming Growth Factor-β (TGF-β) signaling pathway and promoted ovarian fibrosis. Increased TNF-α, IL-1 and NF-κB expression also indicated the occurrence of ovarian inflammation. Exposure to 3-MCPD stimulated the caspase pathway and enhanced granulosa cell apoptosis. Consistent with disrupted ovarian homeostasis, 3-MCPD exposure interfered with mitochondrial function, generated more reactive oxygen species, increased ferrous ion and lipid peroxidation levels, and resulted in decreased oocyte development potential. Collectively, these findings indicated that 3-MCPD exposure induced ovarian inflammation and fibrosis, and caused disorders of mitochondrial function and ferrous ion homeostasis in oocytes, which consequently disturbed follicle maturation and reduced oocyte quality.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: 3-MCPD; Fibrosis; Oocyte; Ovary; Reactive oxygen species
المشرفين على المادة: 96-24-2 (alpha-Chlorohydrin)
E1UOL152H7 (Iron)
تواريخ الأحداث: Date Created: 20221117 Date Completed: 20221205 Latest Revision: 20221205
رمز التحديث: 20221205
DOI: 10.1016/j.envpol.2022.120662
PMID: 36395906
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6424
DOI:10.1016/j.envpol.2022.120662