دورية أكاديمية
Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and impediments.
| العنوان: | Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and impediments. |
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| المؤلفون: | Rehman MU; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Electronic address: mrehman1@ksu.edu.sa., Sehar N; Centre for Translational and Clinical Research, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi 110062, India., Dar NJ; School of Medicine, University of Texas Health San Antonio, San Antonio, TX 78992 USA., Khan A; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia., Arafah A; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Rashid S; Department of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia., Rashid SM; Division of Veterinary Biochemistry, Faculty of Veterinary Science and Animal Husbandry, SKUAST-Kashmir, Srinagar, Jammu and Kashmir, India., Ganaie MA; Department of Pharmacology & Toxicology, College of Dentistry and Pharmacy, Buraydah Colleges, Buraydah, Saudi Arabia. |
| المصدر: | Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2023 Jan; Vol. 144, pp. 104961. Date of Electronic Publication: 2022 Nov 14. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: United States NLM ID: 7806090 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7528 (Electronic) Linking ISSN: 01497634 NLM ISO Abbreviation: Neurosci Biobehav Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Pergamon Press Original Publication: Fayetteville, N. Y., ANKHO International Inc. |
| مواضيع طبية MeSH: | Neurodegenerative Diseases*/metabolism, Humans ; Neuroinflammatory Diseases ; Quality of Life ; Oxidative Stress ; Mitochondria/metabolism |
| مستخلص: | Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease (PD), and Huntington disease (HD) represent a major socio-economic challenge in view of their high prevalence yet poor treatment outcomes affecting quality of life. The major challenge in drug development for these NDs is insufficient clarity about the mechanisms involved in pathogenesis and pathophysiology. Mitochondrial dysfunction, oxidative stress and inflammation are common pathways that are linked to neuronal abnormalities and initiation of these diseases. Thus, elucidating the shared initial molecular and cellular mechanisms is crucial for recognizing novel remedial targets, and developing therapeutics to impede or stop disease progression. In this context, use of multifunctional compounds at early stages of disease development unclogs new avenues as it acts on act on multiple targets in comparison to single target concept. In this review, we summarize overview of the major findings and advancements in recent years focusing on shared mechanisms for better understanding might become beneficial in searching more potent pharmacological interventions thereby reducing the onset or severity of various NDs. (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Autophagy; Mitochondrial dysfunction; Multitargeted therapeutics; Neurodegenerative diseases; Neuroinflammation; Oxidative stress |
| تواريخ الأحداث: | Date Created: 20221117 Date Completed: 20230103 Latest Revision: 20230225 |
| رمز التحديث: | 20230225 |
| DOI: | 10.1016/j.neubiorev.2022.104961 |
| PMID: | 36395982 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-7528 |
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| DOI: | 10.1016/j.neubiorev.2022.104961 |