دورية أكاديمية
أعرض في EDS

LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.

التفاصيل البيبلوغرافية
العنوان: LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.
المؤلفون: Wu Z; Department Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany., Berlemann LA; Department Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany., Bader V; Department Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.; Department Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany., Sehr DA; Department Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany., Dawin E; Department Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.; Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V, Dortmund, Germany., Covallero A; Department of Biomedical Sciences, University of Padua, Padua, Italy., Meschede J; Department Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany., Angersbach L; Department Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany., Showkat C; Department Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany., Michaelis JB; Faculty of Medicine, Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany., Münch C; Faculty of Medicine, Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany., Rieger B; Institute for Integrative Cell Biology and Physiology, Faculty of Biology, University of Münster, Münster, Germany., Namgaladze D; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany., Herrera MG; Department Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany., Fiesel FC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience PhD Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Springer W; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience PhD Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Mendes M; Proteomics of Cellular Signaling, Department of Infection and Immunity, Luxembourg Institute of Health, Strassen, Luxembourg., Stepien J; Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.; Medical Proteome Analysis, Center for Protein Diagnostics (PRODI), Ruhr-University Bochum, Bochum, Germany., Barkovits K; Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.; Medical Proteome Analysis, Center for Protein Diagnostics (PRODI), Ruhr-University Bochum, Bochum, Germany., Marcus K; Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.; Medical Proteome Analysis, Center for Protein Diagnostics (PRODI), Ruhr-University Bochum, Bochum, Germany., Sickmann A; Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V, Dortmund, Germany., Dittmar G; Proteomics of Cellular Signaling, Department of Infection and Immunity, Luxembourg Institute of Health, Strassen, Luxembourg.; Department of Life Sciences and Medicine, University of Luxembourg, Belvaux, Luxembourg., Busch KB; Institute for Integrative Cell Biology and Physiology, Faculty of Biology, University of Münster, Münster, Germany., Riedel D; Laboratory for Electron Microscopy, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Brini M; Department of Biology, University of Padua, Padua, Italy.; Centro Studi per la Neurodegenerazione (CESNE), University of Padova, Padua, Italy., Tatzelt J; Department Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.; RESOLV Cluster of Excellence, Ruhr University Bochum, Bochum, Germany., Cali T; Department of Biomedical Sciences, University of Padua, Padua, Italy.; Centro Studi per la Neurodegenerazione (CESNE), University of Padova, Padua, Italy.; Padua Neuroscience Center (PNC), University of Padua, Padua, Italy., Winklhofer KF; Department Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.; RESOLV Cluster of Excellence, Ruhr University Bochum, Bochum, Germany.
المصدر: The EMBO journal [EMBO J] 2022 Dec 15; Vol. 41 (24), pp. e112006. Date of Electronic Publication: 2022 Nov 18.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
أسماء مطبوعة: Publication: 2024- : [London] : Nature Publishing Group
Original Publication: Eynsham, Oxford, England : Published for the European Molecular Biology Organization by IRL Press, [c1982-
مواضيع طبية MeSH: NF-kappa B*/genetics , NF-kappa B*/metabolism , Ubiquitin*/metabolism, Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Signal Transduction/physiology ; Mitochondria/metabolism ; Ubiquitination
مستخلص: Mitochondria are increasingly recognized as cellular hubs to orchestrate signaling pathways that regulate metabolism, redox homeostasis, and cell fate decisions. Recent research revealed a role of mitochondria also in innate immune signaling; however, the mechanisms of how mitochondria affect signal transduction are poorly understood. Here, we show that the NF-κB pathway activated by TNF employs mitochondria as a platform for signal amplification and shuttling of activated NF-κB to the nucleus. TNF treatment induces the recruitment of HOIP, the catalytic component of the linear ubiquitin chain assembly complex (LUBAC), and its substrate NEMO to the outer mitochondrial membrane, where M1- and K63-linked ubiquitin chains are generated. NF-κB is locally activated and transported to the nucleus by mitochondria, leading to an increase in mitochondria-nucleus contact sites in a HOIP-dependent manner. Notably, TNF-induced stabilization of the mitochondrial kinase PINK1 furthermore contributes to signal amplification by antagonizing the M1-ubiquitin-specific deubiquitinase OTULIN. Overall, our study reveals a role for mitochondria in amplifying TNF-mediated NF-κB activation, both serving as a signaling platform, as well as a transport mode for activated NF-κB to the nuclear.
(© 2022 The Authors. Published under the terms of the CC BY NC ND 4.0 license.)
References: Biochem Soc Trans. 2022 Apr 29;50(2):799-811. (PMID: 35343567)
J Neurosci. 2007 Nov 7;27(45):12413-8. (PMID: 17989306)
Cold Spring Harb Perspect Biol. 2013 Jun 01;5(6):. (PMID: 23732472)
J Neurosci. 2001 Jul 1;21(13):4668-77. (PMID: 11425894)
Trends Cell Biol. 2020 Apr;30(4):263-275. (PMID: 32200805)
EMBO Rep. 2021 Sep 6;22(9):e53086. (PMID: 34337844)
J Neurosci. 2016 Apr 13;36(15):4351-61. (PMID: 27076430)
Nature. 2022 Feb;602(7897):487-495. (PMID: 34942634)
Mol Cell. 2009 Mar 13;33(5):602-15. (PMID: 19185524)
Nature. 2021 Jun;594(7861):111-116. (PMID: 34012115)
Hum Mol Genet. 2011 May 15;20(10):1966-74. (PMID: 21355049)
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2647-52. (PMID: 19196984)
Cell Death Differ. 2021 Feb;28(2):473-492. (PMID: 33441937)
Mol Cell Biol. 1996 Mar;16(3):1058-65. (PMID: 8622650)
J Cell Biol. 2014 Apr 28;205(2):143-53. (PMID: 24751536)
Mol Cell. 2022 Apr 21;82(8):1501-1513. (PMID: 35364016)
Cell Rep. 2016 Mar 29;14(12):2846-58. (PMID: 26997266)
Curr Biol. 2022 Jun 6;32(11):R506-R508. (PMID: 35671719)
J Neuroinflammation. 2012 Dec 17;9:271. (PMID: 23244239)
J Cell Biol. 2010 Nov 29;191(5):933-42. (PMID: 21115803)
Nature. 2013 Jun 20;498(7454):318-24. (PMID: 23708998)
Front Cell Dev Biol. 2022 Feb 11;10:796066. (PMID: 35223833)
Front Chem. 2020 Jan 10;7:915. (PMID: 31998699)
J Neurosci. 2006 Jan 4;26(1):143-51. (PMID: 16399681)
Nat Rev Immunol. 2015 Jun;15(6):362-74. (PMID: 26008591)
Nat Protoc. 2009;4(1):44-57. (PMID: 19131956)
Nat Commun. 2020 Nov 27;11(1):6069. (PMID: 33247103)
Nat Rev Mol Cell Biol. 2020 Apr;21(4):204-224. (PMID: 32071438)
PLoS One. 2011 Jan 13;6(1):e16038. (PMID: 21249202)
Dis Model Mech. 2008 Sep-Oct;1(2-3):168-74; discussion 173. (PMID: 19048081)
Mol Cell. 2009 Dec 11;36(5):831-44. (PMID: 20005846)
Cell. 2005 Sep 9;122(5):669-82. (PMID: 16125763)
Mol Cell. 2013 Jun 27;50(6):818-830. (PMID: 23806334)
EMBO J. 2019 May 2;38(9):. (PMID: 30886048)
Cell Rep. 2017 Jul 5;20(1):30-39. (PMID: 28683321)
Neuron. 1994 Jan;12(1):139-53. (PMID: 7507336)
J Neurosci. 2007 Feb 21;27(8):1868-78. (PMID: 17314283)
Cell Death Differ. 2017 Jul;24(7):1172-1183. (PMID: 28362430)
J Neurosci. 2011 Jul 13;31(28):10249-61. (PMID: 21753002)
Biomolecules. 2022 Mar 10;12(3):. (PMID: 35327619)
EMBO J. 2022 Jun 14;41(12):e109460. (PMID: 35491809)
J Cell Biol. 2021 Nov 1;220(11):. (PMID: 34694322)
J Biol Chem. 2015 Jul 3;290(27):16882-93. (PMID: 25987559)
Mol Cell. 2018 Apr 19;70(2):211-227.e8. (PMID: 29656925)
Hum Mol Genet. 2011 Mar 1;20(5):867-79. (PMID: 21138942)
Cell Rep. 2016 Aug 30;16(9):2271-80. (PMID: 27545878)
Hum Mol Genet. 2010 Jan 15;19(2):352-63. (PMID: 19880420)
Nat Microbiol. 2017 May 08;2:17063. (PMID: 28481331)
J Mol Biol. 2020 Jan 3;432(1):206-230. (PMID: 31299243)
Mol Cell. 2013 Mar 7;49(5):908-21. (PMID: 23453807)
Open Biol. 2022 Jan;12(1):210264. (PMID: 35042401)
Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15247-52. (PMID: 23986494)
Curr Opin Genet Dev. 2017 Jun;44:47-53. (PMID: 28213158)
Cell Res. 2010 Sep;20(9):994-1011. (PMID: 20628368)
Trends Cell Biol. 2016 Oct;26(10):733-744. (PMID: 27291334)
J Neurosci. 2002 Oct 1;22(19):8466-75. (PMID: 12351721)
Cell. 2009 Mar 20;136(6):1098-109. (PMID: 19303852)
EMBO J. 2015 Feb 3;34(3):307-25. (PMID: 25527291)
Int J Mol Sci. 2020 May 11;21(9):. (PMID: 32403254)
Cells. 2021 Oct 09;10(10):. (PMID: 34685685)
Mol Cell Biol. 2001 Oct;21(19):6640-50. (PMID: 11533251)
EMBO Rep. 2012 Sep;13(9):840-6. (PMID: 22791023)
J Mol Biol. 2012 May 4;418(3-4):134-44. (PMID: 22227388)
EMBO Rep. 2018 Apr;19(4):. (PMID: 29475881)
Cell. 2013 Jun 6;153(6):1312-26. (PMID: 23746843)
EMBO Rep. 2009 May;10(5):466-73. (PMID: 19373254)
Neuron. 2017 Nov 1;96(3):651-666. (PMID: 29096078)
Nat Rev Mol Cell Biol. 2018 Jan 23;19(2):93-108. (PMID: 29358684)
EMBO J. 2006 Oct 18;25(20):4877-87. (PMID: 17006537)
Nat Protoc. 2016 Dec;11(12):2301-2319. (PMID: 27809316)
Sci Rep. 2021 Jun 11;11(1):12347. (PMID: 34117308)
Nucleic Acids Res. 2009 Jan;37(1):1-13. (PMID: 19033363)
Curr Opin Cell Biol. 2020 Aug;65:58-65. (PMID: 32208350)
Trends Mol Med. 2018 Jan;24(1):49-65. (PMID: 29217118)
Sci Adv. 2020 Dec 18;6(51):. (PMID: 33355129)
J Neurosci. 2018 Apr 25;38(17):4093-4103. (PMID: 29555853)
Nat Protoc. 2021 Nov;16(11):5287-5308. (PMID: 34686857)
J Neurochem. 2011 Jun;117(5):856-67. (PMID: 21426348)
Cell Death Differ. 2021 Feb;28(2):557-569. (PMID: 33473179)
Cell. 2012 Mar 16;148(6):1145-59. (PMID: 22424226)
Nat Rev Mol Cell Biol. 2020 Feb;21(2):85-100. (PMID: 31636403)
Nature. 2022 Feb;602(7896):328-335. (PMID: 34933320)
Immunity. 2015 Mar 17;42(3):406-17. (PMID: 25786173)
Science. 2019 Aug 16;365(6454):. (PMID: 31416937)
FEBS J. 2016 Jul;283(14):2626-39. (PMID: 26749412)
Nat Cell Biol. 2009 Feb;11(2):123-32. (PMID: 19136968)
Biochem Biophys Res Commun. 2016 Jun 3;474(3):452-461. (PMID: 27133719)
Sci Signal. 2020 Feb 04;13(617):. (PMID: 32019898)
Trends Immunol. 2021 Jul;42(7):590-603. (PMID: 34074601)
Semin Immunol. 2014 Jun;26(3):253-66. (PMID: 24958609)
Curr Biol. 2018 Feb 19;28(4):R170-R185. (PMID: 29462587)
Neuroscience. 2015 Apr 16;291:70-80. (PMID: 25659345)
Mol Cell Biol. 2014 Apr;34(7):1322-35. (PMID: 24469399)
Cytokine. 2018 Jan;101:26-32. (PMID: 27623350)
Diabetes. 2007 Oct;56(10):2569-78. (PMID: 17686943)
FEBS J. 2017 Jan;284(2):196-210. (PMID: 27283924)
Nat Microbiol. 2017 May 08;2:17066. (PMID: 28481361)
EMBO J. 2001 Apr 17;20(8):1910-20. (PMID: 11296224)
J Cell Biol. 2020 Sep 7;219(9):. (PMID: 32556086)
Mol Cell. 2022 Jan 6;82(1):44-59.e6. (PMID: 34875213)
J Biol Chem. 2011 Jul 22;286(29):26107-17. (PMID: 21622571)
Cell Death Differ. 2017 Jul;24(7):1153-1159. (PMID: 28475177)
J Neurosci. 2006 May 3;26(18):4870-9. (PMID: 16672661)
J Cell Sci. 2019 Jan 18;132(2):. (PMID: 30659056)
EMBO J. 2016 Sep 1;35(17):1868-84. (PMID: 27307491)
Cell Death Differ. 2018 Jun;25(6):1131-1145. (PMID: 29229997)
Mol Cell. 2014 Nov 6;56(3):360-375. (PMID: 25284222)
Front Cell Dev Biol. 2021 Jul 27;9:720490. (PMID: 34386501)
Nat Immunol. 2020 Jan;21(1):17-29. (PMID: 31819255)
Nat Rev Mol Cell Biol. 2020 Jan;21(1):7-24. (PMID: 31732717)
EMBO Rep. 2012 Apr;13(4):378-85. (PMID: 22354088)
Cell Mol Life Sci. 2012 Oct;69(19):3301-15. (PMID: 22643835)
PLoS One. 2007 Jul 11;2(7):e589. (PMID: 17622342)
Cell Death Differ. 2021 Feb;28(2):493-504. (PMID: 33288901)
Autophagy. 2013 Nov 1;9(11):1758-69. (PMID: 24121706)
EMBO Rep. 2015 Sep;16(9):1114-30. (PMID: 26162776)
Nat Commun. 2019 Sep 20;10(1):4320. (PMID: 31541095)
Nat Neurosci. 2003 Oct;6(10):1072-8. (PMID: 12947408)
Nat Rev Immunol. 2020 Sep;20(9):537-551. (PMID: 32203325)
Nat Commun. 2019 Mar 20;10(1):1287. (PMID: 30894536)
معلومات مُعتمدة: R01 NS085070 United States NS NINDS NIH HHS; R01 NS110085 United States NS NINDS NIH HHS; RF1 NS085070 United States NS NINDS NIH HHS; U54 NS110435 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: HOIP; NEMO; OTULIN; PINK1; ubiquitin
المشرفين على المادة: 0 (NF-kappa B)
0 (Ubiquitin)
EC 2.3.2.27 (Ubiquitin-Protein Ligases)
تواريخ الأحداث: Date Created: 20221118 Date Completed: 20221216 Latest Revision: 20240707
رمز التحديث: 20240707
مُعرف محوري في PubMed: PMC9753471
DOI: 10.15252/embj.2022112006
PMID: 36398858
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-2075
DOI:10.15252/embj.2022112006