دورية أكاديمية
Evaluation of loci to predict ear morphology using two SNaPshot assays.
العنوان: | Evaluation of loci to predict ear morphology using two SNaPshot assays. |
---|---|
المؤلفون: | Noreen S; Department of Forensic Sciences, University of Health Sciences, Lahore, 54600, Pakistan.; King's Forensics, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, UK., Ballard D; King's Forensics, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, UK., Mehmood T; School of Natural Sciences (SNS), National University of Sciences and Technology (NUST), Islamabad, H-12, Pakistan., Khan A; Genomics Group, Faculty of Biosciences and Aquaculture, Nord University, 8049, Bodø, Norway. arif.khan@nord.no., Khalid T; Department of Human Genetics and Molecular Biology, University of Health Sciences, Lahore, 54600, Pakistan., Rakha A; Department of Forensic Sciences, University of Health Sciences, Lahore, 54600, Pakistan. |
المصدر: | Forensic science, medicine, and pathology [Forensic Sci Med Pathol] 2023 Sep; Vol. 19 (3), pp. 335-356. Date of Electronic Publication: 2022 Nov 19. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 101236111 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-2891 (Electronic) Linking ISSN: 1547769X NLM ISO Abbreviation: Forensic Sci Med Pathol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Totowa, N.J. : Humana Press, c2005- |
مواضيع طبية MeSH: | Eye Color* , DNA*, Humans ; Genotype ; Phenotype ; DNA Primers ; Forensic Genetics/methods ; Polymorphism, Single Nucleotide |
مستخلص: | Human ear morphology prediction with SNP-based genotypes is growing in forensic DNA phenotyping and is scarcely explored in Pakistan as a part of EVCs (externally visible characteristics). The ear morphology prediction assays with 21 SNPs were assessed for their potential utility in forensic identification of population. The SNaPshot™ multiplex chemistries, capillary electrophoresis methods and GeneMapper™ software were used for obtaining genotypic data. A total of 33 ear phenotypes were categorized with digital photographs of 300 volunteers. SHEsis software was applied to make LD plot. Ordinal and multinomial logistic regression was implemented for association testing. Multinomial logistic regression was executed to construct the prediction model in 90% training and 10% testing subjects. Several influential SNPs for ear phenotypic variation were found in association testing. The model based on genetic markers predicted ear phenotypes with moderate to good predictive accuracies demonstrated with the area under curve (AUC), sensitivity and specificity of predicted phenotypes. As an additional EVC, the estimated ear phenotypic profiles have the possibility of determining the human ear morphology differences in unknown biological samples found in crimes that do not result in a criminal database hit. Furthermore, this can help in facial reconstruction and act as an investigational lead. (© 2022. The Author(s).) |
References: | J Physiol. 2013 Apr 15;591(8):2055-66. (PMID: 23401613) Investig Genet. 2013 Jan 14;4(1):3. (PMID: 23317428) Forensic Sci Int Genet. 2014 Mar;9:111-7. (PMID: 24528589) Methods Mol Biol. 2009;578:379-91. (PMID: 19768606) PLoS One. 2017 Apr 25;12(4):e0176566. (PMID: 28441456) Nat Commun. 2015 Jun 24;6:7500. (PMID: 26105758) Int J Legal Med. 2017 Jan;131(1):21-37. (PMID: 27841004) Homo. 2017 May;68(3):222-235. (PMID: 28416164) Hum Genet. 2008 Sep;124(2):179-85. (PMID: 18704500) Trends Genet. 2018 Jul;34(7):489-491. (PMID: 29674182) Forensic Sci Int Genet. 2011 Nov;5(5):472-8. (PMID: 21050833) Nucleic Acids Res. 2007 Jul;35(Web Server issue):W71-4. (PMID: 17485472) Hum Genet. 2015 Aug;134(8):823-35. (PMID: 25963972) JAMA. 2008 Mar 19;299(11):1335-44. (PMID: 18349094) Am J Hum Genet. 2017 Dec 7;101(6):913-924. (PMID: 29198719) Forensic Sci Int. 2001 Nov 1;122(2-3):124-9. (PMID: 11672965) Forensic Sci Med Pathol. 2008;4(3):196-9. (PMID: 19291462) Pak Dev Rev. 1994 Winter;33(4 Pt 2):663-74. (PMID: 12346199) Forensic Sci Int Genet. 2018 Jul;35:123-135. (PMID: 29753263) J Med Genet. 2014 Oct;51(10):635-45. (PMID: 25118188) Am J Hum Genet. 2004 May;74(5):827-45. (PMID: 15077202) Forensic Sci Int Genet. 2011 Jun;5(3):170-80. (PMID: 20457092) Eur J Med Genet. 2014 Aug;57(8):394-401. (PMID: 24880027) Nat Genet. 2008 May;40(5):584-91. (PMID: 18391950) Nat Genet. 2007 Dec;39(12):1443-52. (PMID: 17952075) Cell Res. 2005 Feb;15(2):97-8. (PMID: 15740637) Nat Rev Genet. 2009 Aug;10(8):565-77. (PMID: 19584810) J Forensic Sci. 2007 Mar;52(2):286-93. (PMID: 17316223) Biotechniques. 2004 Aug;37(2):226-31. (PMID: 15335214) Int J Legal Med. 2014 May;128(3):447-53. (PMID: 24395150) Comput Struct Biotechnol J. 2019 Jul 29;17:1056-1065. (PMID: 31452858) PLoS One. 2015 May 22;10(5):e0127852. (PMID: 26001114) Nat Commun. 2015 Mar 24;6:6596. (PMID: 25803618) Forensic Sci Int Genet. 2019 Sep;42:252-259. (PMID: 31400656) Forensic Sci Int Genet. 2014 Nov;13:208-16. (PMID: 25194685) Anthropol Anz. 1994 Mar;52(1):17-22. (PMID: 8192432) Leg Med (Tokyo). 2019 May;38:14-24. (PMID: 30925380) Homo. 2009;60(5):461-72. (PMID: 19748090) J Forensic Sci. 2012 Nov;57(6):1427-41. (PMID: 22594579) Forensic Sci Int Genet. 2011 Nov;5(5):464-71. (PMID: 20947461) Forensic Sci Rev. 2017 Jan;29(1):57-76. (PMID: 28119267) Sci Rep. 2020 Jul 17;10(1):11902. (PMID: 32681043) PLoS Genet. 2005 Dec;1(6):e70. (PMID: 16355252) Forensic Sci Int Genet. 2015 Sep;18:33-48. (PMID: 25716572) Cell. 2016 Aug 25;166(5):1061-1064. (PMID: 27565333) Nat Rev Genet. 2009 Apr;10(4):241-51. (PMID: 19293820) Forensic Sci Int Genet. 2009 Jun;3(3):154-61. (PMID: 19414162) Pharmacogenomics J. 2003;3(2):77-96. (PMID: 12746733) Forensic Sci Int Genet. 2014 Mar;9:150-61. (PMID: 24528593) |
معلومات مُعتمدة: | IRSIP Higher Education Commission, Pakistan |
فهرسة مساهمة: | Keywords: EVCs; Ear morphology predictions; Forensic DNA phenotyping; Predictive DNA analysis |
المشرفين على المادة: | 9007-49-2 (DNA) 0 (DNA Primers) |
تواريخ الأحداث: | Date Created: 20221119 Date Completed: 20230926 Latest Revision: 20231027 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10518297 |
DOI: | 10.1007/s12024-022-00545-7 |
PMID: | 36401782 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1556-2891 |
---|---|
DOI: | 10.1007/s12024-022-00545-7 |