دورية أكاديمية

Chemsex in HIV pre-exposure prophylaxis users: Assessment of mood disorders and addictive behavior.

التفاصيل البيبلوغرافية
العنوان: Chemsex in HIV pre-exposure prophylaxis users: Assessment of mood disorders and addictive behavior.
المؤلفون: Peyriere H; INSERM U1175/IRD UMI 233, Montpellier University, Montpellier, France.; Pathogenesis and Control of Chronic Infections, University of Montpellier, INSERM, EFS, CHU Montpellier, Montpellier, France., Jacquet JM; Department of Addictology, Nimes University Hospital, Nimes, France., Peries M; Pathogenesis and Control of Chronic Infections, University of Montpellier, INSERM, EFS, CHU Montpellier, Montpellier, France., Tribout V; Sexual Transmitted Infections Center, Montpellier University, Montpellier, France., Broche B; Sexual Transmitted Infections Center, Nimes, France., Mauboussin JM; Infectious Diseases Department, Nimes University Hospital, Nimes, France., Makinson A; INSERM U1175/IRD UMI 233, Montpellier University, Montpellier, France.; Infectious Diseases Department, Montpellier University Hospital, Montpellier, France., Perrollaz C; Sexual Transmitted Infections Center, Montpellier University, Montpellier, France., Ferreyra M; Sexual Transmitted Infections Center, Perpignan, France., Rouanet I; Infectious Diseases Department, Nimes University Hospital, Nimes, France., Montoya-Ferrer A; Infectious Diseases Department, Montpellier University Hospital, Montpellier, France., El-Majjaoui S; Sexual Transmitted Infections Center, Nimes, France., Corriol-Bonifas F; Infectious Diseases Department, Alès Hospital, Alès, France., Fraisse T; Infectious Diseases Department, Alès Hospital, Alès, France., Grau F; Sexual Transmitted Infections Center, Nimes, France., Laureillard D; Infectious Diseases Department, Nimes University Hospital, Nimes, France., Nagot N; Pathogenesis and Control of Chronic Infections, University of Montpellier, INSERM, EFS, CHU Montpellier, Montpellier, France., Reynes J; INSERM U1175/IRD UMI 233, Montpellier University, Montpellier, France.; Infectious Diseases Department, Montpellier University Hospital, Montpellier, France., Donnadieu-Rigole H; Pathogenesis and Control of Chronic Infections, University of Montpellier, INSERM, EFS, CHU Montpellier, Montpellier, France.; Department of Addictology, Montpellier University Hospital, Montpellier, France.
المصدر: Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2023 Jun; Vol. 37 (3), pp. 639-649. Date of Electronic Publication: 2022 Dec 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Science Country of Publication: England NLM ID: 8710411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-8206 (Electronic) Linking ISSN: 07673981 NLM ISO Abbreviation: Fundam Clin Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2001->: Oxford : Blackwell Science
Original Publication: Paris ; New York : Elsevier, c1987-
مواضيع طبية MeSH: HIV Infections*/diagnosis , HIV Infections*/prevention & control , Pre-Exposure Prophylaxis* , Behavior, Addictive* , Substance-Related Disorders*/prevention & control, Adult ; Male ; Humans ; Homosexuality, Male/psychology ; Mood Disorders/prevention & control ; Cross-Sectional Studies
مستخلص: The assessment of mood disorders and addiction linked to the practice of chemsex is of interest given the psychoactive substances used. The aim of this study was to assess risky sexual and addictive behavior to chemsex and related anxiety/depression symptoms in individuals receiving HIV pre-exposure prophylaxis (PrEP). In this cross-sectional study, all adults presenting for PrEP renewal at French sexual health centers were enrolled from January 2018 to March 2019. Participants completed a questionnaire on chemsex (i.e., the use of psychoactive substances before/during sex), including adapted Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) to chemsex addiction (questions of ASSIST were modified to focus on chemsex). Anxiety/depression was assessed with the Hospital Anxiety and Depression Scale. In the last 3 months before enrollment, 39.8% (94/236) of participants reported chemsex. The main psychoactive substances consumed during chemsex were cathinones (74.6%), gamma-hydroxybutyrate (66.3%), and other psychostimulants (60%). The median score of the chemsex-focused ASSIST was 8 [IQR 25-75 : 3-15]; 72.2% of participants had a score justifying at least a brief intervention (>4). In multivariate analyses, anxiety and cathinones consumption were associated with an ASSIST score >4: OR 13.65 ( 95% CI 1.68-662.7), P = 0.0062, and OR 8.468 ( 95% CI 2.066-43.059), P = 0.0014, respectively. The level of addiction to the practice of chemsex can be difficult to estimate for the user, and the ASSIST makes it possible to evaluate this addiction and to direct the subjects toward specialized consultations of addictology, sexual health, or PrEP renewals. The implementation of the modified ASSIST in these consultations can allow early systematic screening and counseling.
(© 2022 Société Française de Pharmacologie et de Thérapeutique. Published by John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: HIV pre-exposure prophylaxis; chemsex; chemsex addiction; cross-sectional study; mood disorders
تواريخ الأحداث: Date Created: 20221120 Date Completed: 20230512 Latest Revision: 20230512
رمز التحديث: 20231215
DOI: 10.1111/fcp.12854
PMID: 36403123
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-8206
DOI:10.1111/fcp.12854