دورية أكاديمية
أعرض في EDS

Higher systemic inflammatory status and cardiovascular risk associated with Charcot arthropathy unrelated to infection or extremity amputation.

التفاصيل البيبلوغرافية
العنوان: Higher systemic inflammatory status and cardiovascular risk associated with Charcot arthropathy unrelated to infection or extremity amputation.
المؤلفون: de Vasconcelos JC; Endocrinology Division, Department of Internal Medicine (Endocrinology), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo Brazil., Atala YB; Endocrinology Division, Department of Internal Medicine (Endocrinology), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo Brazil., Zantut-Wittmann DE; Endocrinology Division, Department of Internal Medicine (Endocrinology), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo Brazil., Parisi MCR; Endocrinology Division, Department of Internal Medicine (Endocrinology), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo Brazil.
المصدر: Journal of diabetes and metabolic disorders [J Diabetes Metab Disord] 2022 Jun 20; Vol. 21 (2), pp. 1407-1413. Date of Electronic Publication: 2022 Jun 20 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101590741 Publication Model: eCollection Cited Medium: Print ISSN: 2251-6581 (Print) Linking ISSN: 22516581 NLM ISO Abbreviation: J Diabetes Metab Disord Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2018- : [Cham] : Springer International Publishing
Original Publication: 2011: Tehran : Tehran University of Medical Sciences, Endocrinology and Metabolism Research Institute
مستخلص: Purpose: People with diabetes and Charcot arthropathy have higher mortality than people with diabetes without this complication. Are the causes of this higher mortality exclusively infectious or of a cardiovascular origin? We aimed to study aspects related to cardiovascular risk and inflammation in a population of people with type 2 diabetes with and without Charcot arthropathy.
Methods: A cross-sectional study was performed in people with diabetes and Charcot Eickenholtz III arthropathy, matched for sex and age, with two groups of people with diabetes without Charcot arthropathy with and without peripheral sensory-motor neuropathy, in the absence of active infection. All participants underwent clinical and laboratory evaluation at the time of the interview, and their cardiovascular risk was calculated according to the United Kingdom Prospective Diabetes Study (UKPDS) calculator.
Results: We evaluated 69 people with type 2 diabetes (21 with Charcot arthropathy, 24 with diabetic peripheral neuropathy and 24 without this neuropathy), with a mean age between 57 and 61 years and with a diabetes duration of more than 10 years. Patients with Charcot arthropathy had a longer duration of diabetes; more frequency of dyslipidemia; and higher levels of uric acid, microalbuminuria and C-reactive protein than the other two groups. A total of 73.9% of the people evaluated had high or very high cardiovascular risk according to the UKPDS score.
Conclusion: The people with type 2 diabetes presenting Charcot arthropathy had greater values of systemic inflammatory parameters, even in the chronic phase of the complication, with a higher risk of mortality unrelated to infections.
Competing Interests: Conflicts of interestWe declare that we had no personal, academic or financial conflicts of interest in the preparation of this article.
(© The Author(s), under exclusive licence to Tehran University of Medical Sciences 2022.)
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فهرسة مساهمة: Keywords: Cardiovascular risk; Charcot arthropathy; Systemic inflammation; Type 2 diabetes mellitus
تواريخ الأحداث: Date Created: 20221121 Latest Revision: 20230621
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9672227
DOI: 10.1007/s40200-022-01073-5
PMID: 36404847
قاعدة البيانات: MEDLINE
الوصف
تدمد:2251-6581
DOI:10.1007/s40200-022-01073-5