دورية أكاديمية
Design, Synthesis, α-Amylase/α-Glucosidase Inhibition Assay, Induced Fit Docking Study of New Hybrid Compounds Containing 4H-Pyrano[2,3-d]pyrimidine, 1H-1,2,3-Triazole and D-Glucose Components.
| العنوان: | Design, Synthesis, α-Amylase/α-Glucosidase Inhibition Assay, Induced Fit Docking Study of New Hybrid Compounds Containing 4H-Pyrano[2,3-d]pyrimidine, 1H-1,2,3-Triazole and D-Glucose Components. |
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| المؤلفون: | Toan VN; Faculty of Chemistry, University of Science (Vietnam National University, Hanoi), 19 Le Thanh Tong, Hoan Kiem, Ha Noi, Viet Nam.; Institute of New Technology, Academy of Military Science and Technology, Ministry of Defence, 17 Hoang Sam, Cau Giay, Ha Noi, Viet Nam., Thanh ND; Faculty of Chemistry, University of Science (Vietnam National University, Hanoi), 19 Le Thanh Tong, Hoan Kiem, Ha Noi, Viet Nam., Huyen LT; Faculty of Chemistry, University of Science (Vietnam National University, Hanoi), 19 Le Thanh Tong, Hoan Kiem, Ha Noi, Viet Nam., Hanh NT; Faculty of Chemistry, University of Science (Vietnam National University, Hanoi), 19 Le Thanh Tong, Hoan Kiem, Ha Noi, Viet Nam., Hai DS; Faculty of Chemistry, University of Science (Vietnam National University, Hanoi), 19 Le Thanh Tong, Hoan Kiem, Ha Noi, Viet Nam.; Institute of Science and Technology, Ministry of Public Security of Vietnam, 47 Pham Van Dong, Cau Giay, Ha Noi, Viet Nam., Anh HH; Faculty of Chemistry, University of Science (Vietnam National University, Hanoi), 19 Le Thanh Tong, Hoan Kiem, Ha Noi, Viet Nam., Giang NTK; Faculty of Chemistry, University of Science (Vietnam National University, Hanoi), 19 Le Thanh Tong, Hoan Kiem, Ha Noi, Viet Nam.; Institute of Science and Technology, Ministry of Public Security of Vietnam, 47 Pham Van Dong, Cau Giay, Ha Noi, Viet Nam., Van HTK; Faculty of Chemistry, University of Science (Vietnam National University, Hanoi), 19 Le Thanh Tong, Hoan Kiem, Ha Noi, Viet Nam.; Faculty of Chemical Technology, Viet Tri University of Industry, Tien Kien, Lam Thao, Phu Tho, Viet Nam. |
| المصدر: | Chemistry & biodiversity [Chem Biodivers] 2022 Dec; Vol. 19 (12), pp. e202200680. Date of Electronic Publication: 2022 Dec 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004- |
| مواضيع طبية MeSH: | alpha-Glucosidases*/metabolism , Glucose*, Humans ; Glucosidases/metabolism ; alpha-Amylases/metabolism ; Structure-Activity Relationship ; Amylases/metabolism ; Triazoles/chemistry ; Molecular Docking Simulation ; Glycoside Hydrolase Inhibitors/chemistry ; Pyrimidines/pharmacology ; Pyrimidines/chemistry ; Molecular Structure |
| مستخلص: | In this study, the click chemistry between N-propargyl derivatives of substituted 4H-pyrano[2,3-d]pyrimidines and tetra-O-acetyl-α-d-glucopyranosyl azide carried out under catalytic conditions using catalyst CuI@Montmorillonite and additive N,N-diisopropylethylamine (DIPEA). The yields of obtained hybrid compounds having 4H-pyrano[2,3-d]pyrimidine connected to 1H-1,2,3-triazole rings were about 85-94 %. All these synthesized hybrid compounds were examined for in vitro α-amylase (with IC (© 2022 Wiley-VHCA AG, Zurich, Switzerland.) |
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| معلومات مُعتمدة: | 104.01-2020.01 Vietnam National Foundation for Science and Technology Development (NAFOSTED) |
| فهرسة مساهمة: | Keywords: 4H-pyrano[2,3-d]pyrimidines; hybrid compounds; induced fit docking; sugar azide; type 2 diabetes |
| المشرفين على المادة: | EC 3.2.1.20 (alpha-Glucosidases) IY9XDZ35W2 (Glucose) K8CXK5Q32L (pyrimidine) EC 3.2.1.- (Glucosidases) EC 3.2.1.1 (alpha-Amylases) EC 3.2.1.- (Amylases) 0 (Triazoles) 0 (Glycoside Hydrolase Inhibitors) 0 (Pyrimidines) |
| تواريخ الأحداث: | Date Created: 20221121 Date Completed: 20221227 Latest Revision: 20221230 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/cbdv.202200680 |
| PMID: | 36408921 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1612-1880 |
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| DOI: | 10.1002/cbdv.202200680 |