دورية أكاديمية
Prognostic factors and perinatal outcomes in early-onset intrauterine growth restriction due to placental insufficiency.
| العنوان: | Prognostic factors and perinatal outcomes in early-onset intrauterine growth restriction due to placental insufficiency. |
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| المؤلفون: | Faquini SLDL; Department of Fetal Medicine, Instituto de Medicina Integral Prof. Fernando Figueira, Medicina Fetal, Rua dos Coelhos, Recife, Brazil.; Department of Fetal Medicine, Clinical Hospital, Universidade Federal de Pernambuco, Medicina Fetal, Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife, Brazil., Guerra GVQL; Center for Women's Health Care, Instituto de Medicina Integral Prof. Fernando Figueira, Recife, Brazil., Galindo MWS; Department of Medicine, Faculdade Pernambucana de Saúde, Av. Mal. Mascarenhas de Morais, Recife, Brazil., Gusmão IMB; Department of Medicine, Faculdade Pernambucana de Saúde, Av. Mal. Mascarenhas de Morais, Recife, Brazil., Vilela LS; Department of Medicine, Faculdade Pernambucana de Saúde, Av. Mal. Mascarenhas de Morais, Recife, Brazil., Souza AS; Department of Fetal Medicine, Instituto de Medicina Integral Prof. Fernando Figueira, Medicina Fetal, Rua dos Coelhos, Recife, Brazil.; Department of Maternal Child, Universidade Federal de Pernambuco (UFPE), Recife, Brazil. |
| المصدر: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2022 Dec; Vol. 35 (25), pp. 7119-7125. Date of Electronic Publication: 2021 Jul 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4954 (Electronic) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Boca Raton : Parthenon Pub. Group, c2002- |
| مواضيع طبية MeSH: | Placental Insufficiency* , Perinatal Death*/etiology, Infant, Newborn ; Female ; Pregnancy ; Humans ; Fetal Growth Retardation/etiology ; Fetal Growth Retardation/diagnosis ; Birth Weight ; Retrospective Studies ; Prognosis ; Placenta ; Oxygen |
| مستخلص: | Objective: To determine the principal prognostic factors and neonatal outcomes associated with perinatal death in cases of early-onset intrauterine growth restriction (IUGR) due to placental insufficiency and to define the cutoff point for the risk of perinatal death. Methods: A retrospective cohort study conducted with 198 pregnant women with a diagnosis of early-onset IUGR (as detected before the 32nd week of gestational age). The association between the dependent variable (perinatal death) and the independent variables was investigated using a multivariate logistic regression model. The area under the receiver operating characteristic (ROC) curve was calculated to determine the sensitivity and specificity of the adjusted model. A significance level of 5% was established for the entire statistical analysis. Results: Perinatal deaths occurred in 89 (44.9%) of the 198 fetuses with early-onset IUGR. Birthweight <800 grams (OR: 14.73; 95%CI: 4.13-52.54; p < .001), postnatal need for mechanical ventilation (OR: 24.56; 95%CI: 5.58-108.08; p < .001) and postnatal use of an oxygen hood (OR: 0.09; 95%CI: 0.02-0.39; p = .001) remained significantly associated with neonatal death in the multivariate model. The sensitivity, specificity, positive and negative predictive values for birthweight <800 grams and need for mechanical ventilation as predictors of death were, respectively, 84%, 91%, 88%, 88% and 93%, 71%, 60% and 96%, while the values for use of an oxygen hood were, respectively, 15%, 62%, 15% and 62%. Conclusion: The principal determinants of perinatal death in fetuses with early-onset IUGR were birthweight <800 grams, gestational age at delivery <30 weeks and postnatal need for mechanical ventilation as risk factors while postnatal use of an oxygen hood was found to constitute a protective factor. |
| فهرسة مساهمة: | Keywords: Fetal growth retardation placental insufficiency Doppler ultrasonography; umbilical artery pregnancy outcome |
| المشرفين على المادة: | S88TT14065 (Oxygen) |
| تواريخ الأحداث: | Date Created: 20221122 Date Completed: 20221123 Latest Revision: 20221123 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/14767058.2021.1944092 |
| PMID: | 36411677 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1476-4954 |
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| DOI: | 10.1080/14767058.2021.1944092 |