دورية أكاديمية
Protein-coding gene interaction network prediction of bioactive plant compound action against SARS-CoV-2: a novel hypothesis using bioinformatics analysis.
| العنوان: | Protein-coding gene interaction network prediction of bioactive plant compound action against SARS-CoV-2: a novel hypothesis using bioinformatics analysis. |
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| المؤلفون: | Santos Sobrinho EM; Instituto Federal do Norte de Minas Gerais, Campus Araçuaí, BR 367, Km 278, s/n, Zona Rural, 39600-000 Araçuaí, MG, Brazil., Santos HO; Instituto Federal do Norte de Minas Gerais, Campus Araçuaí, BR 367, Km 278, s/n, Zona Rural, 39600-000 Araçuaí, MG, Brazil., Martins ER; Universidade Federal de Minas Gerais, Instituto de Ciências Agrárias, Centro de Pesquisas em Ciências Agrárias, Av. Universitária, 1000, Bairro Universitário, 39404-457 Montes Claros, MG, Brazil., Fonseca FSAD; Universidade Federal de Minas Gerais, Instituto de Ciências Agrárias, Centro de Pesquisas em Ciências Agrárias, Av. Universitária, 1000, Bairro Universitário, 39404-457 Montes Claros, MG, Brazil., Farias LC; Universidade Estadual de Montes Claros, Departamento de Odontologia. Campus Universitário Prof. Darcy Ribeiro, Av. Prof. Rui Braga, s/n, Vila Mauriceia, 39401-089 Montes Claros, MG, Brazil., Aguilar CM; Universidade Federal de Minas Gerais, Instituto de Ciências Agrárias, Centro de Pesquisas em Ciências Agrárias, Av. Universitária, 1000, Bairro Universitário, 39404-457 Montes Claros, MG, Brazil., Pereira UA; Universidade Federal de Minas Gerais, Instituto de Ciências Agrárias, Centro de Pesquisas em Ciências Agrárias, Av. Universitária, 1000, Bairro Universitário, 39404-457 Montes Claros, MG, Brazil., Nicolau Junior N; Universiade Federal de Uberlândia, Instituto de Biotecnologia, Campus Patos de Minas, Av. Getúlio Vargas, 230, Bairro Centro, 38700-103 Patos de Minas, MG, Brazil., Gomes MS; Universiade Federal de Uberlândia, Instituto de Biotecnologia, Campus Patos de Minas, Av. Getúlio Vargas, 230, Bairro Centro, 38700-103 Patos de Minas, MG, Brazil., Souza CN; Universidade Federal de Minas Gerais, Instituto de Ciências Agrárias, Centro de Pesquisas em Ciências Agrárias, Av. Universitária, 1000, Bairro Universitário, 39404-457 Montes Claros, MG, Brazil., Ravnjak JMA; Centro Universitário FIP MOC, Curso de Medicina, Av. Profa. Aida Mainartina Paraiso, 80, Ibituruna, 39408-007 Montes Claros, MG, Brazil., Porto RR; Universiade Federal de Uberlândia, Instituto de Biotecnologia, Campus Patos de Minas, Av. Getúlio Vargas, 230, Bairro Centro, 38700-103 Patos de Minas, MG, Brazil., Almeida AC; Universidade Federal de Minas Gerais, Instituto de Ciências Agrárias, Centro de Pesquisas em Ciências Agrárias, Av. Universitária, 1000, Bairro Universitário, 39404-457 Montes Claros, MG, Brazil. |
| المصدر: | Anais da Academia Brasileira de Ciencias [An Acad Bras Cienc] 2022 Nov 21; Vol. 94 (suppl 3), pp. e20201380. Date of Electronic Publication: 2022 Nov 21 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academia Brasileira De Ciencias Country of Publication: Brazil NLM ID: 7503280 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-2690 (Electronic) Linking ISSN: 00013765 NLM ISO Abbreviation: An Acad Bras Cienc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Rio De Janeiro : Academia Brasileira De Ciencias |
| مواضيع طبية MeSH: | SARS-CoV-2*/genetics , COVID-19 Drug Treatment*, Humans ; Computational Biology ; Caspase 3 ; Resveratrol/pharmacology |
| مستخلص: | This study aimed to verify the action of bioactive compounds from Brazilian plants on the leader genes involved in the SARS-CoV-2 pathway. The main human genes involved were identified in GeneCards and UNIPROT platforms, and an interaction network between leader genes was established in the STRING database. To design chemo-biology interactome networks and elucidate the interplay between genes related to the disease and bioactive plant compounds, the metasearch engine STITCH 3.1 was used. The analysis revealed that SMAD3 and CASP3 genes are leader genes, suggesting that the mechanism of action of the virus on host cells is associated with the molecular effects of these genes. Furthermore, the bioactive plant compounds, such as ascorbate, benzoquinone, ellagic acid, and resveratrol was identified as a promising adjuvant for the treatment inhibiting CASP3-mediated apoptosis. Bioactive plant compounds were verified as the main pathways enriched with KEGG and related to viral infection, assessments/immune/infections, and cell proliferation, which are potentially used for respiratory viral infections. The best-ranked molecule docked in the CASP3 binding site was rutin, while the SMAD3 binding site was resveratrol. In conclusion, this work identified several bioactive compounds from Brazilian plants showing potential antiviral functions that can directly or indirectly inhibit the new coronavirus. |
| المشرفين على المادة: | EC 3.4.22.- (Caspase 3) Q369O8926L (Resveratrol) |
| تواريخ الأحداث: | Date Created: 20221123 Date Completed: 20221125 Latest Revision: 20221207 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1590/0001-3765202220201380 |
| PMID: | 36417598 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-2690 |
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| DOI: | 10.1590/0001-3765202220201380 |