دورية أكاديمية
Comparison of clinical characteristics of wild-type SARS-CoV-2 and Omicron.
| العنوان: | Comparison of clinical characteristics of wild-type SARS-CoV-2 and Omicron. |
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| المؤلفون: | Kirca F; Ankara Şehir Hastanesi, Department of Medical Microbiology - Ankara, Turquia., Aydoğan S; Ankara Şehir Hastanesi, Department of Medical Microbiology - Ankara, Turquia., Gözalan A; Alanya Alaaddin Keykubat University, Department of Medical Microbiology - Antalya, Turquia., Kayipmaz AE; Ankara Şehir Hastanesi, Department of Emergency Medicine - Ankara, Turquia., Özdemir FAE; Ankara Şehir Hastanesi, Department of Radiology - Ankara, Turquia., Tekçe YT; Ankara Şehir Hastanesi, Department of Infectious Disease and Clinical Microbiology - Ankara, Turquia., Beşer İO; Ankara Şehir Hastanesi, Department of Medical Microbiology - Ankara, Turquia., Gün P; Ankara Şehir Hastanesi, Department of Medical Microbiology - Ankara, Turquia., Ökten RS; Ankara Şehir Hastanesi, Department of Radiology - Ankara, Turquia., Dinç B; Ankara Şehir Hastanesi, Department of Medical Microbiology - Ankara, Turquia. |
| المصدر: | Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2022 Nov 21; Vol. 68 (10), pp. 1476-1480. Date of Electronic Publication: 2022 Nov 21 (Print Publication: 2022). |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Associação Médica Brasileira Country of Publication: Brazil NLM ID: 9308586 Publication Model: eCollection Cited Medium: Internet ISSN: 1806-9282 (Electronic) Linking ISSN: 01044230 NLM ISO Abbreviation: Rev Assoc Med Bras (1992) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: São Paulo : Associação Médica Brasileira |
| مواضيع طبية MeSH: | COVID-19* , Pneumonia*, Humans ; Retrospective Studies ; SARS-CoV-2/genetics ; Viral Tropism |
| مستخلص: | Objective: This study aimed to investigate the effect of mutations by comparing wild-type SARS-CoV-2 and Omicron regarding clinical features in patients with COVID-19. It also aimed to assess whether SARS-CoV-2 cycle threshold value could predict COVID-19 severity. Methods: A total of 960 wild-type and 411 Omicron variant patients with positive results in SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction test from oropharyngeal and/or nasopharyngeal samples during their hospital admissions were included in this retrospective study. The reference symptoms of the patients were obtained from the hospital database. The correlation between chest computed tomography findings and the "cycle threshold" of patients with wild-type SARS-CoV-2 was assessed. Results: Cough, fever, shortness of breath, loss of taste and smell, and diarrhea were found to be statistically significantly higher (p=0.001; 0.001; 0.001; 0.001; and 0.006; respectively) in the wild-type cohort, while in the Omicron cohort, sore throat and headache were found to be statistically significantly higher (p=0.001 and 0.003, respectively). An inverse relationship was found between chest computed tomography findings and viral load. Conclusion: This study revealed that the Omicron variant tended to infect predominantly the upper respiratory tract and showed decreased lung infectivity, and the disease progressed with a milder clinical course. Therefore, the study showed that the tropism of the virus was changed and the viral phenotype was affected. It was also found that SARS-CoV-2 viral load did not predict COVID-19 severity in patients with wild-type SARS-CoV-2. |
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| SCR Organism: | SARS-CoV-2 variants |
| تواريخ الأحداث: | Date Created: 20221123 Date Completed: 20221207 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9683927 |
| DOI: | 10.1590/1806-9282.20220880 |
| PMID: | 36417656 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1806-9282 |
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| DOI: | 10.1590/1806-9282.20220880 |