دورية أكاديمية
Profiles and determinants of dicofol, endosulfans, mirex, and toxaphenes in breast milk samples from 10 prefectures in Japan.
| العنوان: | Profiles and determinants of dicofol, endosulfans, mirex, and toxaphenes in breast milk samples from 10 prefectures in Japan. |
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| المؤلفون: | Fujii Y; Department of Pharmaceutical Sciences, Daiichi University of Pharmacy, 22-1 Tamagawa, Minami-ku, Fukuoka, 815-8511, Japan. Electronic address: yu-fujii@umin.ac.jp., Harada KH; Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto, 606-8501, Japan., Ito Y; Department of Pharmaceutical Sciences, Daiichi University of Pharmacy, 22-1 Tamagawa, Minami-ku, Fukuoka, 815-8511, Japan., Yoshitake M; Department of Pharmaceutical Sciences, Daiichi University of Pharmacy, 22-1 Tamagawa, Minami-ku, Fukuoka, 815-8511, Japan., Matsunobu C; Department of Pharmaceutical Sciences, Daiichi University of Pharmacy, 22-1 Tamagawa, Minami-ku, Fukuoka, 815-8511, Japan., Kato Y; Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa, 769-2193, Japan., Ohta C; Faculty of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Johnan-ku, Fukuoka, 814-0198, Japan., Koga N; Faculty of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Johnan-ku, Fukuoka, 814-0198, Japan., Kimura O; School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan., Endo T; School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan., Koizumi A; Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto, 606-8501, Japan., Haraguchi K; Department of Pharmaceutical Sciences, Daiichi University of Pharmacy, 22-1 Tamagawa, Minami-ku, Fukuoka, 815-8511, Japan. Electronic address: k-haraguti@daiichi-cps.ac.jp. |
| المصدر: | Chemosphere [Chemosphere] 2023 Jan; Vol. 311 (Pt 1), pp. 137002. Date of Electronic Publication: 2022 Oct 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 0320657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1298 (Electronic) Linking ISSN: 00456535 NLM ISO Abbreviation: Chemosphere Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford, New York, : Pergamon Press. |
| مواضيع طبية MeSH: | Polychlorinated Biphenyls*/analysis , Toxaphene* , Environmental Pollutants*/analysis, Female ; Humans ; Dicofol/analysis ; Endosulfan/analysis ; Mirex/analysis ; Milk, Human/chemistry ; Japan ; Environmental Monitoring ; Ethers ; Lipids |
| مستخلص: | Human exposure to persistent organic pollutants (POPs) is reflected by POP concentrations in breast milk. Many studies of POPs in breast milk have been performed in Japan, but insufficient information is available about some legacy POPs (e.g., mirex and toxaphenes, included in the Stockholm Convention in 2001) and novel POPs (e.g., dicofol and endosulfans, included in the Stockholm Convention in 2019 and 2011, respectively). In this study, dicofol, endosulfan, mirex, and toxaphene concentrations in breast milk from 10 prefectures in Japan were determined. The samples were collected between 2005 and 2010, before Stockholm Convention restrictions on endosulfans and mirex were implemented. Common POPs (e.g., polychlorinated biphenyls) were also analyzed to allow the contamination statuses to be compared. The α-endosulfan and β-endosulfan concentrations were 0.26-13 and 0.012-0.82 ng/g lipid, respectively. The toxaphene #26 and #50 concentrations were <0.08-5.6 and < 0.1-8.5 ng/g lipid, respectively. The dicofol concentrations were <0.01-4.8 ng/g lipid. The mirex concentrations were <0.2-3.5 ng/g lipid. The α- and β-endosulfan concentrations on a lipid weight basis negatively correlated with the lipid contents of the milk samples (ρ = -0.65, p < 0.01 for α-endosulfan; ρ = -0.58, p < 0.01 for β-endosulfan). The toxaphene concentrations positively correlated with the lipid contents. The mirex concentrations positively correlated with the maternal age but negatively correlated with the maternal body mass index. No correlations between the dicofol concentrations and the factors were found. Principal component analysis divided the data into four groups, (1) chlordanes, dichlorodiphenyltrichloroethanes and related compounds, hexachlorobenzene, hexachlorocyclohexanes, hexachloroethane, and polychlorinated biphenyls, (2) endosulfans, (3) dicofol, dieldrin, and toxaphenes, and (4) bromodiphenyl ether 47. This indicated that bromodiphenyl ether 47, dicofol, endosulfans, and toxaphenes have different exposure routes or different kinetics to the other legacy POPs. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Breast milk; Dicofol; Endosulfan; Japan; Mirex; POPs; Toxaphene |
| المشرفين على المادة: | W4WMM0WS91 (Dicofol) OKA6A6ZD4K (Endosulfan) Z917AN264P (Mirex) DFC2HB4I0K (Polychlorinated Biphenyls) 8001-35-2 (Toxaphene) 0 (Environmental Pollutants) 0 (Ethers) 0 (Lipids) |
| تواريخ الأحداث: | Date Created: 20221124 Date Completed: 20221125 Latest Revision: 20221125 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.chemosphere.2022.137002 |
| PMID: | 36419270 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1298 |
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| DOI: | 10.1016/j.chemosphere.2022.137002 |