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Wound Healing and Antioxidant Properties of Launaea procumbens Supported by Metabolomic Profiling and Molecular Docking.

التفاصيل البيبلوغرافية
العنوان: Wound Healing and Antioxidant Properties of Launaea procumbens Supported by Metabolomic Profiling and Molecular Docking.
المؤلفون: Ahmed SR; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street, Cairo 11562, Egypt., Mostafa EM; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Musa A; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt., Rateb EE; Department of Physiology, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, Egypt., Al-Sanea MM; Pharmaceutical Chemistry Department, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia., Abu-Baih DH; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Deraya University, New Minia 61111, Egypt., Elrehany MA; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Deraya University, New Minia 61111, Egypt.; Department of Biochemistry, Faculty of Medicine, Minia University, Minia 61519, Egypt., Saber EA; Department of Medical Sciences (Histology), Deraya University, New Minia 61111, Egypt., Rateb ME; School of Computing, Engineering & Physical Sciences, University of the West of Scotland, Paisley PA1 2BE, UK., Abdelmohsen UR; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, New Minia 61111, Egypt.
المصدر: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2022 Nov 16; Vol. 11 (11). Date of Electronic Publication: 2022 Nov 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101668981 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3921 (Print) Linking ISSN: 20763921 NLM ISO Abbreviation: Antioxidants (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: Wounds adversely affect people’s quality of life and have psychological, social, and economic impacts. Herbal remedies of Launaea procumbens (LP) are used to treat wounds. In an excision wound model, topical application of LP significantly promoted wound closure (on day 14, LP-treated animals had the highest percentages of wound closure in comparison with the other groups, as the wound was entirely closed with a closure percentage of 100%, p < 0.05). Histological analysis revealed a considerable rise in the number of fibroblasts, the amount of collagen, and its cross-linking in LP-treated wounds. Gene expression patterns showed significant elevation of TGF-β levels (2.1-fold change after 7 days treatment and 2.7-fold change in 14 days treatment) and downregulation of the inflammatory TNF-α and IL-1β levels in LP-treated wounds. Regarding in vitro antioxidant activity, LP extract significantly diminished the formation of H2O2 radical (IC50 = 171.6 μg/mL) and scavenged the superoxide radical (IC50 of 286.7 µg/mL), indicating antioxidant potential in a dose-dependent manner. Dereplication of the secondary metabolites using LC-HRMS resulted in the annotation of 16 metabolites. The identified compounds were docked against important wound-healing targets, including vascular endothelial growth factor (VEGF), collagen α-1, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and transforming growth factor-β (TGF-β). Among dereplicated compounds, luteolin 8-C-glucoside (orientin) demonstrated binding potential to four investigated targets (VEGF, interleukin 1β, TNF-α, and collagen α-1). To conclude, Launaea procumbens extract could be regarded as a promising topical therapy to promote wound healing in excisional wounds, and luteolin 8-C-glucoside (orientin), one of its constituents, is a potential wound-healing drug lead.
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فهرسة مساهمة: Keywords: LC-HRMS profiling; Launaea procumbens; antioxidant; docking; luteolin 8-C-glucoside; wound healing
تواريخ الأحداث: Date Created: 20221124 Latest Revision: 20230308
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9687060
DOI: 10.3390/antiox11112258
PMID: 36421445
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-3921
DOI:10.3390/antiox11112258