دورية أكاديمية
Systematic analysis of changes in radiomics features during dynamic breast-MRI: Evaluation of specific biomarkers.
| العنوان: | Systematic analysis of changes in radiomics features during dynamic breast-MRI: Evaluation of specific biomarkers. |
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| المؤلفون: | Landsmann A; Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland. Electronic address: anna.landsmann@usz.ch., Ruppert C; Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland. Electronic address: Carlotta.ruppert@uzh.ch., Nowakowska S; Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland. Electronic address: sylwia.nowakowska@usz.ch., Ciritsis A; Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland. Electronic address: alexander.ciritsis@usz.ch., Wieler J; Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland. Electronic address: jann.wieler@usz.ch., Wurnig MC; Institute of Diagnostic Radiology, Hospital Lachen AG, Switzerland. Electronic address: moritz.wurnig@spital-lachen.ch., Rossi C; Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland. Electronic address: cristina.rossi@usz.ch., Boss A; Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland. Electronic address: andreas.boss@usz.ch. |
| المصدر: | Clinical imaging [Clin Imaging] 2023 Jan; Vol. 93, pp. 93-102. Date of Electronic Publication: 2022 Oct 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 8911831 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4499 (Electronic) Linking ISSN: 08997071 NLM ISO Abbreviation: Clin Imaging Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [New York, NY] : Elsevier, [c1989- |
| مواضيع طبية MeSH: | Magnetic Resonance Imaging*, Humans ; Retrospective Studies ; Radiography ; Biomarkers |
| مستخلص: | Objectives: In this retrospective, single-center study we investigate the changes of radiomics features during dynamic breast-MRI for healthy tissue compared to benign and malignant lesions. Methods: 60 patients underwent breast-MRI using a dynamic 3D gradient-echo sequence. Changes of 34 texture features (TF) in 30 benign and 30 malignant lesions were calculated for 5 dynamic datasets and corresponding 4 subtraction datasets. Statistical analysis was performed with ANOVA, and systematic changes in features were described by linear and polynomial regression models. Results: ANOVA revealed significant differences (p < 0.05) between normal tissue and lesions in 13 TF, compared to 9 TF between benign and malignant lesions. Most TF showed significant differences in early dynamic and subtraction datasets. TF associated with homogeneity were suitable to discriminate between healthy parenchyma and lesions, whereas run-length features were more suitable to discriminate between benign and malignant lesions. Run length nonuniformity (RLN) was the only feature able to distinguish between all three classes with an AUC of 88.3%. Characteristic changes were observed with a systematic increase or decrease for most TF with mostly polynomial behavior. Slopes showed earlier peaks in malignant lesions, compared to benign lesions. Mean values for the coefficient of determination were higher during subtraction sequences, compared to dynamic sequences (benign: 0.98 vs 0. 72; malignant: 0.94 vs 0.74). Conclusions: TF of breast lesions follow characteristic patterns during dynamic breast-MRI, distinguishing benign from malignant lesions. Early dynamic and subtraction datasets are particularly suitable for texture analysis in breast-MRI. Features associated with tissue homogeneity seem to be indicative of benign lesions. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Breast cancer; Breast magnetic resonance imaging; Contrast enhanced breast-MRI; Radiomics; Texture analysis |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20221124 Date Completed: 20221130 Latest Revision: 20221130 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.clinimag.2022.10.013 |
| PMID: | 36423483 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-4499 |
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| DOI: | 10.1016/j.clinimag.2022.10.013 |