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Development and Validation of an LC-MS/MS Method for Simultaneous Determination of Short Peptide-Based Drugs in Human Blood Plasma.

التفاصيل البيبلوغرافية
العنوان: Development and Validation of an LC-MS/MS Method for Simultaneous Determination of Short Peptide-Based Drugs in Human Blood Plasma.
المؤلفون: Fisher EN; I.M. Sechenov First MSMU of the Ministry of Health of the Russian Federation, Sechenov University, 8, Trubetskaya Street, 119991 Moscow, Russia.; LLC «CPHA», 20/3, Nauchny Proezd, 117246 Moscow, Russia., Melnikov ES; I.M. Sechenov First MSMU of the Ministry of Health of the Russian Federation, Sechenov University, 8, Trubetskaya Street, 119991 Moscow, Russia.; Clinical Hospital. I. V. Davidovsky, Department of Health of the City of Moscow, 11, Yauzskaya Street, 119027 Moscow, Russia., Gegeckori V; I.M. Sechenov First MSMU of the Ministry of Health of the Russian Federation, Sechenov University, 8, Trubetskaya Street, 119991 Moscow, Russia., Potoldykova NV; Institute for Urology and Reproductive Health, I.M. Sechenov First MSMU of the Ministry of Health of the Russian Federation, Sechenov University, 8, Trubetskaya Street, 119991 Moscow, Russia., Enikeev DV; Institute for Urology and Reproductive Health, I.M. Sechenov First MSMU of the Ministry of Health of the Russian Federation, Sechenov University, 8, Trubetskaya Street, 119991 Moscow, Russia., Pavlenko KA; Moscow Clinical Scientific Center, 86, Shosse Enthuziastov, 111123 Moscow, Russia., Agatonovic-Kustrin S; I.M. Sechenov First MSMU of the Ministry of Health of the Russian Federation, Sechenov University, 8, Trubetskaya Street, 119991 Moscow, Russia.; Department of Pharmacy and Biological Sciences, La Trobe University, Edwards Road, Flora Hill, VIC 3550, Australia., Morton DW; I.M. Sechenov First MSMU of the Ministry of Health of the Russian Federation, Sechenov University, 8, Trubetskaya Street, 119991 Moscow, Russia.; Department of Pharmacy and Biological Sciences, La Trobe University, Edwards Road, Flora Hill, VIC 3550, Australia., Ramenskaya GV; I.M. Sechenov First MSMU of the Ministry of Health of the Russian Federation, Sechenov University, 8, Trubetskaya Street, 119991 Moscow, Russia.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2022 Nov 14; Vol. 27 (22). Date of Electronic Publication: 2022 Nov 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Tandem Mass Spectrometry*/methods , Plasma*, Humans ; Chromatography, Liquid/methods ; Reproducibility of Results ; Peptides
مستخلص: A novel HPLC-ESI-MS/MS method for simultaneous gonadotropin-releasing hormone (GnRH) analogs and somatostatin analog quantitation was developed and validated. The developed method was successfully applied to pharmacokinetic studies. The sample preparation process included solid-phase extraction (SPE). Effective chromatographic separation of the analytes and internal standard (dalargin) was achieved with a C18 column, using a gradient elution with two mobile phases: 0.1% v / v formic acid (aqueous solution) and 0.1% v / v formic acid (acetonitrile solution). The linearity of the method was demonstrated within a concentration range of 0.5-20 ng/mL, with correlation coefficients between 0.998-0.999 for goserelin, buserelin, triptorelin, and octreotide, respectively. The relative standard deviation (RSD, %) values for method accuracy and precision did not exceed 20% at the lower level of quantitation (LLOQ) or 15% at other concentration levels.
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فهرسة مساهمة: Keywords: GnRH analogs; LC-ESI-MS/MS; peptide drugs; solid-phase extraction; somatostatin analogue
المشرفين على المادة: 0YIW783RG1 (formic acid)
0 (Peptides)
تواريخ الأحداث: Date Created: 20221126 Date Completed: 20221129 Latest Revision: 20221213
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9695356
DOI: 10.3390/molecules27227831
PMID: 36431933
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules27227831